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Watchful Waiting after Radiochemotherapy in Rectal Cancer: When Is It Feasible?

Abstract

A "watch and wait" strategy in rectal cancer is increasingly considered in patients who achieve an excellent response to radiotherapy. While a growing number of studies have shown the feasibility of this strategy in selected patients, the optimal therapeutic regimen to maximize response rates still needs to be established. Furthermore, accurate response prediction and the management of minor residual findings after radiotherapy remain a matter of debate. Finally, concerns regarding the long-term oncological safety of the "watch and wait" approach have been expressed. Therefore, the present review aims to address the open questions in the context of a "watch and wait" strategy and focuses on the diagnosis of a clinical complete response and the ideal management thereafter.

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  • Authors+Show Affiliations

    ,

    Department of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany. German Cancer Research Center (DKFZ) Heidelberg and German Consortium for Translational Cancer Research (DKTK), Partner Site Tübingen, Tübingen, Germany.

    ,

    Department of Surgery, University Hospital Tübingen, Tübingen, Germany.

    Department of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany. German Cancer Research Center (DKFZ) Heidelberg and German Consortium for Translational Cancer Research (DKTK), Partner Site Tübingen, Tübingen, Germany.

    Source

    Visceral medicine 35:2 2019 Apr pg 119-123

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    31192245

    Citation

    Gani, Cihan, et al. "Watchful Waiting After Radiochemotherapy in Rectal Cancer: when Is It Feasible?" Visceral Medicine, vol. 35, no. 2, 2019, pp. 119-123.
    Gani C, Kirschniak A, Zips D. Watchful Waiting after Radiochemotherapy in Rectal Cancer: When Is It Feasible? Visc Med. 2019;35(2):119-123.
    Gani, C., Kirschniak, A., & Zips, D. (2019). Watchful Waiting after Radiochemotherapy in Rectal Cancer: When Is It Feasible? Visceral Medicine, 35(2), pp. 119-123. doi:10.1159/000499167.
    Gani C, Kirschniak A, Zips D. Watchful Waiting After Radiochemotherapy in Rectal Cancer: when Is It Feasible. Visc Med. 2019;35(2):119-123. PubMed PMID: 31192245.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Watchful Waiting after Radiochemotherapy in Rectal Cancer: When Is It Feasible? AU - Gani,Cihan, AU - Kirschniak,Andreas, AU - Zips,Daniel, Y1 - 2019/03/27/ PY - 2019/02/19/received PY - 2019/02/25/accepted PY - 2020/04/01/pmc-release PY - 2019/6/14/entrez PY - 2019/6/14/pubmed PY - 2019/6/14/medline KW - Cancer KW - Complete response KW - Organ preservation KW - Radiotherapy KW - Rectal cancer SP - 119 EP - 123 JF - Visceral medicine JO - Visc Med VL - 35 IS - 2 N2 - A "watch and wait" strategy in rectal cancer is increasingly considered in patients who achieve an excellent response to radiotherapy. While a growing number of studies have shown the feasibility of this strategy in selected patients, the optimal therapeutic regimen to maximize response rates still needs to be established. Furthermore, accurate response prediction and the management of minor residual findings after radiotherapy remain a matter of debate. Finally, concerns regarding the long-term oncological safety of the "watch and wait" approach have been expressed. Therefore, the present review aims to address the open questions in the context of a "watch and wait" strategy and focuses on the diagnosis of a clinical complete response and the ideal management thereafter. SN - 2297-4725 UR - https://www.unboundmedicine.com/medline/citation/31192245/Watchful_Waiting_after_Radiochemotherapy_in_Rectal_Cancer:_When_Is_It_Feasible L2 - https://www.karger.com?DOI=10.1159/000499167 DB - PRIME DP - Unbound Medicine ER -