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Watchful Waiting after Radiochemotherapy in Rectal Cancer: When Is It Feasible?
Visc Med 2019; 35(2):119-123VM

Abstract

A "watch and wait" strategy in rectal cancer is increasingly considered in patients who achieve an excellent response to radiotherapy. While a growing number of studies have shown the feasibility of this strategy in selected patients, the optimal therapeutic regimen to maximize response rates still needs to be established. Furthermore, accurate response prediction and the management of minor residual findings after radiotherapy remain a matter of debate. Finally, concerns regarding the long-term oncological safety of the "watch and wait" approach have been expressed. Therefore, the present review aims to address the open questions in the context of a "watch and wait" strategy and focuses on the diagnosis of a clinical complete response and the ideal management thereafter.

Authors+Show Affiliations

Department of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany. German Cancer Research Center (DKFZ) Heidelberg and German Consortium for Translational Cancer Research (DKTK), Partner Site Tübingen, Tübingen, Germany.Department of Surgery, University Hospital Tübingen, Tübingen, Germany.Department of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany. German Cancer Research Center (DKFZ) Heidelberg and German Consortium for Translational Cancer Research (DKTK), Partner Site Tübingen, Tübingen, Germany.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31192245

Citation

Gani, Cihan, et al. "Watchful Waiting After Radiochemotherapy in Rectal Cancer: when Is It Feasible?" Visceral Medicine, vol. 35, no. 2, 2019, pp. 119-123.
Gani C, Kirschniak A, Zips D. Watchful Waiting after Radiochemotherapy in Rectal Cancer: When Is It Feasible? Visc Med. 2019;35(2):119-123.
Gani, C., Kirschniak, A., & Zips, D. (2019). Watchful Waiting after Radiochemotherapy in Rectal Cancer: When Is It Feasible? Visceral Medicine, 35(2), pp. 119-123. doi:10.1159/000499167.
Gani C, Kirschniak A, Zips D. Watchful Waiting After Radiochemotherapy in Rectal Cancer: when Is It Feasible. Visc Med. 2019;35(2):119-123. PubMed PMID: 31192245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Watchful Waiting after Radiochemotherapy in Rectal Cancer: When Is It Feasible? AU - Gani,Cihan, AU - Kirschniak,Andreas, AU - Zips,Daniel, Y1 - 2019/03/27/ PY - 2019/02/19/received PY - 2019/02/25/accepted PY - 2020/04/01/pmc-release PY - 2019/6/14/entrez PY - 2019/6/14/pubmed PY - 2019/6/14/medline KW - Cancer KW - Complete response KW - Organ preservation KW - Radiotherapy KW - Rectal cancer SP - 119 EP - 123 JF - Visceral medicine JO - Visc Med VL - 35 IS - 2 N2 - A "watch and wait" strategy in rectal cancer is increasingly considered in patients who achieve an excellent response to radiotherapy. While a growing number of studies have shown the feasibility of this strategy in selected patients, the optimal therapeutic regimen to maximize response rates still needs to be established. Furthermore, accurate response prediction and the management of minor residual findings after radiotherapy remain a matter of debate. Finally, concerns regarding the long-term oncological safety of the "watch and wait" approach have been expressed. Therefore, the present review aims to address the open questions in the context of a "watch and wait" strategy and focuses on the diagnosis of a clinical complete response and the ideal management thereafter. SN - 2297-4725 UR - https://www.unboundmedicine.com/medline/citation/31192245/Watchful_Waiting_after_Radiochemotherapy_in_Rectal_Cancer:_When_Is_It_Feasible L2 - https://www.karger.com?DOI=10.1159/000499167 DB - PRIME DP - Unbound Medicine ER -