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Gelatin-Collagen Nonwoven Scaffold Provides an Alternative to Suprathel for Treatment of Superficial Skin Defects.
Adv Skin Wound Care. 2019 Jul; 32(7):329-332.AS

Abstract

OBJECTIVE

To evaluate the effect of a new biologic gelatin-collagen nonwoven scaffold compared with a more common synthetic wound dressing on the healing of superficial wounds.

METHODS

Three superficial wounds with a depth of 0.5 mm and a length of 2.4 cm were created on the flanks of six minipigs using a skin dermatome. One wound on each pig was treated with the new nonwoven scaffold, one with the more common synthetic wound dressing, and one functioned as an untreated control wound. All three wounds were then covered with a semipermeable, sterile, transparent film.

RESULTS

After 7 days, complete wound closure of all wounds could be detected; epidermal thickness and the number of epidermal cells of all treated wounds were significantly increased compared with the control wounds. The nonwoven dressing showed slightly better results compared with the more common dressing.

CONCLUSIONS

The nonwoven scaffold is an interesting and competitive material for promoting epidermal wound healing. Because it is a biologic dressing, it degenerates completely and does not have to be removed from the wound. Further research should be conducted to compare this new dressing with other currently available wound treatments.

Authors+Show Affiliations

At the time this article was written, at the Clinic of Plastic, Reconstructive, Hand and Burn Surgery, Eberhard Karls University, Tuebingen, Germany, Jennifer L. Schiefer, MD, was a resident; Rebekka Rath was a medical student; Manuel Held, MD, was a resident; Wiebke Petersen was a medical student; Jan-Ole Werner was a medical student; and Hans-Eberhard Schaller, MD, was Director. Afshin Rahmanian-Schwarz, MD, was Director, Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, Helios Clinic, University of Witten/Herdeke, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31192866

Citation

Schiefer, Jennifer L., et al. "Gelatin-Collagen Nonwoven Scaffold Provides an Alternative to Suprathel for Treatment of Superficial Skin Defects." Advances in Skin & Wound Care, vol. 32, no. 7, 2019, pp. 329-332.
Schiefer JL, Rath R, Held M, et al. Gelatin-Collagen Nonwoven Scaffold Provides an Alternative to Suprathel for Treatment of Superficial Skin Defects. Adv Skin Wound Care. 2019;32(7):329-332.
Schiefer, J. L., Rath, R., Held, M., Werner, J. O., Petersen, W., Schaller, H. E., & Rahmanian-Schwarz, A. (2019). Gelatin-Collagen Nonwoven Scaffold Provides an Alternative to Suprathel for Treatment of Superficial Skin Defects. Advances in Skin & Wound Care, 32(7), 329-332. https://doi.org/10.1097/01.ASW.0000558047.07348.3b
Schiefer JL, et al. Gelatin-Collagen Nonwoven Scaffold Provides an Alternative to Suprathel for Treatment of Superficial Skin Defects. Adv Skin Wound Care. 2019;32(7):329-332. PubMed PMID: 31192866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gelatin-Collagen Nonwoven Scaffold Provides an Alternative to Suprathel for Treatment of Superficial Skin Defects. AU - Schiefer,Jennifer L, AU - Rath,Rebekka, AU - Held,Manuel, AU - Werner,Jan-Ole, AU - Petersen,Wiebke, AU - Schaller,Hans-Eberhard, AU - Rahmanian-Schwarz,Afshin, PY - 2019/6/14/pubmed PY - 2020/1/8/medline PY - 2019/6/14/entrez SP - 329 EP - 332 JF - Advances in skin & wound care JO - Adv Skin Wound Care VL - 32 IS - 7 N2 - OBJECTIVE: To evaluate the effect of a new biologic gelatin-collagen nonwoven scaffold compared with a more common synthetic wound dressing on the healing of superficial wounds. METHODS: Three superficial wounds with a depth of 0.5 mm and a length of 2.4 cm were created on the flanks of six minipigs using a skin dermatome. One wound on each pig was treated with the new nonwoven scaffold, one with the more common synthetic wound dressing, and one functioned as an untreated control wound. All three wounds were then covered with a semipermeable, sterile, transparent film. RESULTS: After 7 days, complete wound closure of all wounds could be detected; epidermal thickness and the number of epidermal cells of all treated wounds were significantly increased compared with the control wounds. The nonwoven dressing showed slightly better results compared with the more common dressing. CONCLUSIONS: The nonwoven scaffold is an interesting and competitive material for promoting epidermal wound healing. Because it is a biologic dressing, it degenerates completely and does not have to be removed from the wound. Further research should be conducted to compare this new dressing with other currently available wound treatments. SN - 1538-8654 UR - https://www.unboundmedicine.com/medline/citation/31192866/Gelatin_Collagen_Nonwoven_Scaffold_Provides_an_Alternative_to_Suprathel_for_Treatment_of_Superficial_Skin_Defects_ L2 - http://dx.doi.org/10.1097/01.ASW.0000558047.07348.3b DB - PRIME DP - Unbound Medicine ER -