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Sleep macro-architecture and micro-architecture in children born preterm with sleep disordered breathing.

Abstract

BACKGROUND

Both preterm birth and sleep disordered breathing (SDB) affect sleep in children. We compared the effects of SDB on sleep macro-architecture and micro-architecture in children born preterm (N = 50) and children born at term (N = 50). We hypothesized that sleep would be more disrupted in children born preterm.

METHODS

Polysomnographic studies matched for age (3-12 years) and SDB severity were analyzed. Sleep macro-architecture was assessed using standard criteria and micro-architecture was evaluated using spectral analysis of the electroencephalogram and slow wave activity (SWA) calculated for each sleep stage across the night.

RESULTS

Ex-preterm children (gestational age 29.3 ± 3.6 weeks, mean ± standard error of the mean) were not different from controls for demographic or respiratory parameters or sleep macro-architecture. Theta power in N2 tended to be higher for F4 (p < 0.05) and C4 (p < 0.07). In the second non-rapid eye movement period, SWA was significantly higher in the preterm group compared to the term group for both F4 and C4 (p < 0.05 for both).

CONCLUSIONS

Sleep micro-architecture in children born preterm showed increased theta power and SWA. These differences provide evidence of increased sleep debt and reduced dissipation of sleep debt across the night. Further studies are required to identify if these findings are related to impaired neurocognition and behavior.

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  • Authors+Show Affiliations

    ,

    The Ritchie Centre, Hudson Institute of Medical Research and Department of Paediatrics, Monash University, Melbourne, VIC, Australia. The Chinese University of Hong Kong, Shatin, Hong Kong.

    ,

    The Ritchie Centre, Hudson Institute of Medical Research and Department of Paediatrics, Monash University, Melbourne, VIC, Australia. The Chinese University of Hong Kong, Shatin, Hong Kong.

    ,

    The Ritchie Centre, Hudson Institute of Medical Research and Department of Paediatrics, Monash University, Melbourne, VIC, Australia.

    ,

    The Ritchie Centre, Hudson Institute of Medical Research and Department of Paediatrics, Monash University, Melbourne, VIC, Australia. Melbourne Children's Sleep Centre, Monash Children's Hospital, Melbourne, VIC, Australia.

    ,

    The Ritchie Centre, Hudson Institute of Medical Research and Department of Paediatrics, Monash University, Melbourne, VIC, Australia.

    The Ritchie Centre, Hudson Institute of Medical Research and Department of Paediatrics, Monash University, Melbourne, VIC, Australia. rosemary.horne@monash.edu.

    Source

    Pediatric research : 2019 Jun 13 pg

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31195406

    Citation

    Chan, Martin, et al. "Sleep Macro-architecture and Micro-architecture in Children Born Preterm With Sleep Disordered Breathing." Pediatric Research, 2019.
    Chan M, Wong TCH, Weichard A, et al. Sleep macro-architecture and micro-architecture in children born preterm with sleep disordered breathing. Pediatr Res. 2019.
    Chan, M., Wong, T. C. H., Weichard, A., Nixon, G. M., Walter, L. M., & Horne, R. S. C. (2019). Sleep macro-architecture and micro-architecture in children born preterm with sleep disordered breathing. Pediatric Research, doi:10.1038/s41390-019-0453-1.
    Chan M, et al. Sleep Macro-architecture and Micro-architecture in Children Born Preterm With Sleep Disordered Breathing. Pediatr Res. 2019 Jun 13; PubMed PMID: 31195406.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Sleep macro-architecture and micro-architecture in children born preterm with sleep disordered breathing. AU - Chan,Martin, AU - Wong,Tracy C H, AU - Weichard,Aidan, AU - Nixon,Gillian M, AU - Walter,Lisa M, AU - Horne,Rosemary S C, Y1 - 2019/06/13/ PY - 2019/04/03/received PY - 2019/05/29/accepted PY - 2019/05/16/revised PY - 2019/6/14/pubmed PY - 2019/6/14/medline PY - 2019/6/14/entrez JF - Pediatric research JO - Pediatr. Res. N2 - BACKGROUND: Both preterm birth and sleep disordered breathing (SDB) affect sleep in children. We compared the effects of SDB on sleep macro-architecture and micro-architecture in children born preterm (N = 50) and children born at term (N = 50). We hypothesized that sleep would be more disrupted in children born preterm. METHODS: Polysomnographic studies matched for age (3-12 years) and SDB severity were analyzed. Sleep macro-architecture was assessed using standard criteria and micro-architecture was evaluated using spectral analysis of the electroencephalogram and slow wave activity (SWA) calculated for each sleep stage across the night. RESULTS: Ex-preterm children (gestational age 29.3 ± 3.6 weeks, mean ± standard error of the mean) were not different from controls for demographic or respiratory parameters or sleep macro-architecture. Theta power in N2 tended to be higher for F4 (p < 0.05) and C4 (p < 0.07). In the second non-rapid eye movement period, SWA was significantly higher in the preterm group compared to the term group for both F4 and C4 (p < 0.05 for both). CONCLUSIONS: Sleep micro-architecture in children born preterm showed increased theta power and SWA. These differences provide evidence of increased sleep debt and reduced dissipation of sleep debt across the night. Further studies are required to identify if these findings are related to impaired neurocognition and behavior. SN - 1530-0447 UR - https://www.unboundmedicine.com/medline/citation/31195406/Sleep_macro-architecture_and_micro-architecture_in_children_born_preterm_with_sleep_disordered_breathing L2 - http://dx.doi.org/10.1038/s41390-019-0453-1 DB - PRIME DP - Unbound Medicine ER -