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Utility and Predictive Value of Human Standard Semen Parameters and Sperm DNA Dispersion for Fertility Potential.

Abstract

Because the assessment of sperm DNA fragmentation (SDF) plays a key role in male fertility, our study was designed to find the relationships between SDF and standard semen parameters. The receiver operating characteristic (ROC) curve showed that 18% SDF is a prognostic parameter for discriminating between men with normal and abnormal standard semen parameters (n = 667). Men with > 18% SDF had significantly lower quality semen, a higher prevalence of abnormal semen characteristics, and a higher odds ratio for abnormal semen parameters compared to men with ≤ 18% SDF. An ROC analysis provided predictive values for age and semen parameters to distinguish between men with SDF > 18% and men with ≤ 18% SDF. SDF was positively correlated with male age and teratozoospermia index but negatively with sperm concentration, total number of spermatozoa, sperm morphology, progressive motility, and vitality. Our study shows that 18% SDF has a predictive value for distinguishing between men with normal and abnormal semen characteristics. Men with >18% SDF have a higher risk for abnormal semen parameters, while age and obtained semen parameters have a predictive value for SDF. There is a relationship between SDF and conventional sperm characteristics, and thus, SDF can be incorporated into male fertility assessment.

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  • Authors+Show Affiliations

    ,

    Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. kamilgill@wp.pl.

    ,

    Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. jakubik_joanna@wp.pl.

    ,

    Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. rosiak.aleksandra@yahoo.com. VitroLive Fertility Clinic in Szczecin, 70-483 Szczecin, Poland. rosiak.aleksandra@yahoo.com.

    ,

    Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. michalkups1@gmail.com. VitroLive Fertility Clinic in Szczecin, 70-483 Szczecin, Poland. michalkups1@gmail.com. Department of Urology and Oncological Urology, Regional Specialist Hospital in Szczecin, 71-455 Szczecin, Poland. michalkups1@gmail.com.

    ,

    Healthcare Center Nowe Orlowo, 81-525 Gdynia, Poland. m.lukaszuk@gumed.edu.pl. Invicta Fertility Clinic, 80-850 Gdansk, Poland. m.lukaszuk@gumed.edu.pl.

    ,

    Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland. maciej.kurpisz@igcz.poznan.pl.

    ,

    Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland. monika.fraczek@igcz.poznan.pl.

    Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. mpiasecka@ipartner.com.pl.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31195656

    Citation

    Gill, Kamil, et al. "Utility and Predictive Value of Human Standard Semen Parameters and Sperm DNA Dispersion for Fertility Potential." International Journal of Environmental Research and Public Health, vol. 16, no. 11, 2019.
    Gill K, Jakubik J, Rosiak-Gill A, et al. Utility and Predictive Value of Human Standard Semen Parameters and Sperm DNA Dispersion for Fertility Potential. Int J Environ Res Public Health. 2019;16(11).
    Gill, K., Jakubik, J., Rosiak-Gill, A., Kups, M., Lukaszuk, M., Kurpisz, M., ... Piasecka, M. (2019). Utility and Predictive Value of Human Standard Semen Parameters and Sperm DNA Dispersion for Fertility Potential. International Journal of Environmental Research and Public Health, 16(11), doi:10.3390/ijerph16112004.
    Gill K, et al. Utility and Predictive Value of Human Standard Semen Parameters and Sperm DNA Dispersion for Fertility Potential. Int J Environ Res Public Health. 2019 Jun 5;16(11) PubMed PMID: 31195656.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Utility and Predictive Value of Human Standard Semen Parameters and Sperm DNA Dispersion for Fertility Potential. AU - Gill,Kamil, AU - Jakubik,Joanna, AU - Rosiak-Gill,Aleksandra, AU - Kups,Michał, AU - Lukaszuk,Mariusz, AU - Kurpisz,Maciej, AU - Fraczek,Monika, AU - Piasecka,Małgorzata, Y1 - 2019/06/05/ PY - 2019/05/13/received PY - 2019/05/29/revised PY - 2019/06/03/accepted PY - 2019/6/15/entrez PY - 2019/6/15/pubmed PY - 2019/6/15/medline KW - male fertility potential KW - semen analysis KW - sperm DNA fragmentation JF - International journal of environmental research and public health JO - Int J Environ Res Public Health VL - 16 IS - 11 N2 - Because the assessment of sperm DNA fragmentation (SDF) plays a key role in male fertility, our study was designed to find the relationships between SDF and standard semen parameters. The receiver operating characteristic (ROC) curve showed that 18% SDF is a prognostic parameter for discriminating between men with normal and abnormal standard semen parameters (n = 667). Men with > 18% SDF had significantly lower quality semen, a higher prevalence of abnormal semen characteristics, and a higher odds ratio for abnormal semen parameters compared to men with ≤ 18% SDF. An ROC analysis provided predictive values for age and semen parameters to distinguish between men with SDF > 18% and men with ≤ 18% SDF. SDF was positively correlated with male age and teratozoospermia index but negatively with sperm concentration, total number of spermatozoa, sperm morphology, progressive motility, and vitality. Our study shows that 18% SDF has a predictive value for distinguishing between men with normal and abnormal semen characteristics. Men with >18% SDF have a higher risk for abnormal semen parameters, while age and obtained semen parameters have a predictive value for SDF. There is a relationship between SDF and conventional sperm characteristics, and thus, SDF can be incorporated into male fertility assessment. SN - 1660-4601 UR - https://www.unboundmedicine.com/medline/citation/31195656/Utility_and_Predictive_Value_of_Human_Standard_Semen_Parameters_and_Sperm_DNA_Dispersion_for_Fertility_Potential L2 - http://www.mdpi.com/resolver?pii=ijerph16112004 DB - PRIME DP - Unbound Medicine ER -