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Oxpentifylline and cetiedil citrate improve deformability of dehydrated sickle cells.
J Clin Pathol. 1987 Oct; 40(10):1182-6.JC

Abstract

Erythrocytes from 14 patients with homozygous sickle cell anaemia were treated with the calcium ionophore A23187 to induce loss of cellular potassium and water. The dehydrated cells showed a decrease in filterability (loss of deformability) through pores of 5 micron diameter. Oxpentifylline and cetiedil citrate, which preserve erythrocyte cation and water content, had a significant (p less than 0.01) protective effect against loss of deformability at a concentration of 1 mumol/l. Oxpentifylline showed no adverse effect on the rheology, morphology, or haemolysis of sickle cells at concentrations up to 500 mumol/l. Drugs that act on the erythrocyte membrane to maintain cell hydration are of potential rheological benefit in sickle cell anaemia.

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Authors+Show Affiliations

Stuart J
Department of Haematology, Medical School, University of Birmingham.
Stone PC
No affiliation info available
Bilto YY
No affiliation info available
Keidan AJ
No affiliation info available

MeSH

Anemia, Sickle CellAntisickling AgentsAzepinesCalcimycinDose-Response Relationship, DrugErythrocyte DeformabilityErythrocytes, AbnormalHumansPentoxifyllineTheobromine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3119675

Citation

Stuart, J, et al. "Oxpentifylline and Cetiedil Citrate Improve Deformability of Dehydrated Sickle Cells." Journal of Clinical Pathology, vol. 40, no. 10, 1987, pp. 1182-6.
Stuart J, Stone PC, Bilto YY, et al. Oxpentifylline and cetiedil citrate improve deformability of dehydrated sickle cells. J Clin Pathol. 1987;40(10):1182-6.
Stuart, J., Stone, P. C., Bilto, Y. Y., & Keidan, A. J. (1987). Oxpentifylline and cetiedil citrate improve deformability of dehydrated sickle cells. Journal of Clinical Pathology, 40(10), 1182-6.
Stuart J, et al. Oxpentifylline and Cetiedil Citrate Improve Deformability of Dehydrated Sickle Cells. J Clin Pathol. 1987;40(10):1182-6. PubMed PMID: 3119675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxpentifylline and cetiedil citrate improve deformability of dehydrated sickle cells. AU - Stuart,J, AU - Stone,P C, AU - Bilto,Y Y, AU - Keidan,A J, PY - 1987/10/1/pubmed PY - 1987/10/1/medline PY - 1987/10/1/entrez SP - 1182 EP - 6 JF - Journal of clinical pathology JO - J Clin Pathol VL - 40 IS - 10 N2 - Erythrocytes from 14 patients with homozygous sickle cell anaemia were treated with the calcium ionophore A23187 to induce loss of cellular potassium and water. The dehydrated cells showed a decrease in filterability (loss of deformability) through pores of 5 micron diameter. Oxpentifylline and cetiedil citrate, which preserve erythrocyte cation and water content, had a significant (p less than 0.01) protective effect against loss of deformability at a concentration of 1 mumol/l. Oxpentifylline showed no adverse effect on the rheology, morphology, or haemolysis of sickle cells at concentrations up to 500 mumol/l. Drugs that act on the erythrocyte membrane to maintain cell hydration are of potential rheological benefit in sickle cell anaemia. SN - 0021-9746 UR - https://www.unboundmedicine.com/medline/citation/3119675/Oxpentifylline_and_cetiedil_citrate_improve_deformability_of_dehydrated_sickle_cells_ DB - PRIME DP - Unbound Medicine ER -