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Comparison of Efficacy of Lycopene and Lycopene-Hyaluronidase Combination in the Treatment of Oral Submucous Fibrosis.
J Pharm Bioallied Sci 2019; 11(Suppl 2):S260-S264JP

Abstract

Background

Oral submucous fibrosis (OSMF) is a chronic progressively scarring disease of the oral cavity. Lycopene is a powerful antioxidant obtained from tomatoes and has the highest singlet oxygen quenching capacity and a high capacity of quenching other free radicals in vitro among dietary carotenoids. Hyaluronidase is a substance prepared from the testes and semen of mammals that modifies the permeability of connective tissue through the hydrolysis of hyaluronic acid.

Objective

To evaluate the efficacy of lycopene and lycopene-hyaluronidase combination, and to compare the efficacy of lycopene and lycopene-hyaluronidase combination in the treatment of OSMF.

Study Design

The study consisted of 45 patients with OSMF divided into three equal groups. Patients in Group A were given Lycored 16 mg daily in two equally divided doses for 3 months. Patients in Group B were given LycoRed along with hyaluronidase intralesional injection of 1500 IU twice weekly for 3 months. Patients in Group C were given placebo capsules. Patients were evaluated after 3 months. The following parameters were recorded: mouth opening, visual inspection, palpatory findings, and burning sensation.

Results

There was statistically significant change in mouth opening and burning sensation for lycopene and lycopene-hyaluronidase combination than in the placebo group in the treatment of OSMF, but the lycopene-hyaluronidase combination did not show any statistically significant change when compared with lycopene alone.

Conclusion

Lycopene appears to be a very promising antioxidant in the management of oral submucous fibrosis, both in clinical and symptomatic improvement.

Authors+Show Affiliations

Department of Oral Medicine and Radiology, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India.Department of Public Health Dentistry, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India.Department of Stem Cell and Regenerative Medicine, Oral and Maxillofacial Pathology, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India.Department of Pediatric and Preventive Dentistry, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India.Department of Conservative Dentistry and Endodontics, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India.Department of Oral and Maxillofacial Surgery, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31198349

Citation

Johny, Joseph, et al. "Comparison of Efficacy of Lycopene and Lycopene-Hyaluronidase Combination in the Treatment of Oral Submucous Fibrosis." Journal of Pharmacy & Bioallied Sciences, vol. 11, no. Suppl 2, 2019, pp. S260-S264.
Johny J, Bhagvandas SC, Mohan SP, et al. Comparison of Efficacy of Lycopene and Lycopene-Hyaluronidase Combination in the Treatment of Oral Submucous Fibrosis. J Pharm Bioallied Sci. 2019;11(Suppl 2):S260-S264.
Johny, J., Bhagvandas, S. C., Mohan, S. P., Punathil, S., Moyin, S., & Bhaskaran, M. K. (2019). Comparison of Efficacy of Lycopene and Lycopene-Hyaluronidase Combination in the Treatment of Oral Submucous Fibrosis. Journal of Pharmacy & Bioallied Sciences, 11(Suppl 2), pp. S260-S264. doi:10.4103/JPBS.JPBS_6_19.
Johny J, et al. Comparison of Efficacy of Lycopene and Lycopene-Hyaluronidase Combination in the Treatment of Oral Submucous Fibrosis. J Pharm Bioallied Sci. 2019;11(Suppl 2):S260-S264. PubMed PMID: 31198349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Efficacy of Lycopene and Lycopene-Hyaluronidase Combination in the Treatment of Oral Submucous Fibrosis. AU - Johny,Joseph, AU - Bhagvandas,Sudeep C, AU - Mohan,Sunil Paramel, AU - Punathil,Sameer, AU - Moyin,Shabna, AU - Bhaskaran,Manoj K, PY - 2019/6/15/entrez PY - 2019/6/15/pubmed PY - 2019/6/15/medline KW - Antioxidant KW - efficacy KW - hyaluronidase KW - lycopene KW - oral submucous fibrosis SP - S260 EP - S264 JF - Journal of pharmacy & bioallied sciences JO - J Pharm Bioallied Sci VL - 11 IS - Suppl 2 N2 - Background: Oral submucous fibrosis (OSMF) is a chronic progressively scarring disease of the oral cavity. Lycopene is a powerful antioxidant obtained from tomatoes and has the highest singlet oxygen quenching capacity and a high capacity of quenching other free radicals in vitro among dietary carotenoids. Hyaluronidase is a substance prepared from the testes and semen of mammals that modifies the permeability of connective tissue through the hydrolysis of hyaluronic acid. Objective: To evaluate the efficacy of lycopene and lycopene-hyaluronidase combination, and to compare the efficacy of lycopene and lycopene-hyaluronidase combination in the treatment of OSMF. Study Design: The study consisted of 45 patients with OSMF divided into three equal groups. Patients in Group A were given Lycored 16 mg daily in two equally divided doses for 3 months. Patients in Group B were given LycoRed along with hyaluronidase intralesional injection of 1500 IU twice weekly for 3 months. Patients in Group C were given placebo capsules. Patients were evaluated after 3 months. The following parameters were recorded: mouth opening, visual inspection, palpatory findings, and burning sensation. Results: There was statistically significant change in mouth opening and burning sensation for lycopene and lycopene-hyaluronidase combination than in the placebo group in the treatment of OSMF, but the lycopene-hyaluronidase combination did not show any statistically significant change when compared with lycopene alone. Conclusion: Lycopene appears to be a very promising antioxidant in the management of oral submucous fibrosis, both in clinical and symptomatic improvement. SN - 0976-4879 UR - https://www.unboundmedicine.com/medline/citation/31198349/Comparison_of_Efficacy_of_Lycopene_and_Lycopene-Hyaluronidase_Combination_in_the_Treatment_of_Oral_Submucous_Fibrosis L2 - http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2019;volume=11;issue=6;spage=260;epage=264;aulast=Johny DB - PRIME DP - Unbound Medicine ER -