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Input of recombinant phenotyping for the characterization of a novel acyclovir-resistance mutation identified in a patient with recurrent herpetic keratitis.

Abstract

We report here a case of an immunocompetent patient suffering from recurrent epithelial herpetic keratitis associated with the emergence of antiviral resistance. Indeed, the not previously described amino acid change L340R within herpes simplex virus thymidine kinase, was shown to confer acyclovir-resistance by recombinant phenotyping using bacmid technology.

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  • Publisher Full Text
  • Authors+Show Affiliations

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    Univ. Bordeaux, CHU Bordeaux, Ophthalmology Department, CFXM, F-33000, Bordeaux, France.

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    Univ. Bordeaux, CNRS-UMR 5234, CHU Bordeaux, Virology Department, F-33000, Bordeaux, France.

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    Univ. Bordeaux, CHU Bordeaux, Ophthalmology Department, CFXM, F-33000, Bordeaux, France.

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    Univ. Bordeaux, CHU Bordeaux, Ophthalmology Department, CFXM, F-33000, Bordeaux, France.

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    Univ. Bordeaux, CHU Bordeaux, Ophthalmology Department, CFXM, F-33000, Bordeaux, France.

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    Sorbonne Université, INSERM, Institut Pierre Louis D'Epidémiologie et de Santé Publique (iPLESP), AP-HP, University Hospital Pitié-Salpêtrière - Charles-Foix, National Reference Center for Herpesviruses, Virology Department, Paris, France.

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    Univ. Bordeaux, CNRS-UMR 5234, CHU Bordeaux, Virology Department, F-33000, Bordeaux, France.

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    Sorbonne Université, INSERM, Institut Pierre Louis D'Epidémiologie et de Santé Publique (iPLESP), AP-HP, University Hospital Pitié-Salpêtrière - Charles-Foix, National Reference Center for Herpesviruses, Virology Department, Paris, France.

    Sorbonne Université, INSERM, Institut Pierre Louis D'Epidémiologie et de Santé Publique (iPLESP), AP-HP, University Hospital Pitié-Salpêtrière - Charles-Foix, National Reference Center for Herpesviruses, Virology Department, Paris, France. Electronic address: sonia.burrel@aphp.fr.

    Source

    Antiviral research 168: 2019 Aug pg 183-186

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31199933

    Citation

    Robinet-Perrin, Antoine, et al. "Input of Recombinant Phenotyping for the Characterization of a Novel Acyclovir-resistance Mutation Identified in a Patient With Recurrent Herpetic Keratitis." Antiviral Research, vol. 168, 2019, pp. 183-186.
    Robinet-Perrin A, Tumiotto C, Cornut T, et al. Input of recombinant phenotyping for the characterization of a novel acyclovir-resistance mutation identified in a patient with recurrent herpetic keratitis. Antiviral Res. 2019;168:183-186.
    Robinet-Perrin, A., Tumiotto, C., Cornut, T., Santoni, A., Touboul, D., Goupil-Gouyette, T., ... Burrel, S. (2019). Input of recombinant phenotyping for the characterization of a novel acyclovir-resistance mutation identified in a patient with recurrent herpetic keratitis. Antiviral Research, 168, pp. 183-186. doi:10.1016/j.antiviral.2019.06.007.
    Robinet-Perrin A, et al. Input of Recombinant Phenotyping for the Characterization of a Novel Acyclovir-resistance Mutation Identified in a Patient With Recurrent Herpetic Keratitis. Antiviral Res. 2019;168:183-186. PubMed PMID: 31199933.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Input of recombinant phenotyping for the characterization of a novel acyclovir-resistance mutation identified in a patient with recurrent herpetic keratitis. AU - Robinet-Perrin,Antoine, AU - Tumiotto,Camille, AU - Cornut,Thomas, AU - Santoni,Alexandra, AU - Touboul,David, AU - Goupil-Gouyette,Thibaud, AU - Garrigue,Isabelle, AU - Boutolleau,David, AU - Burrel,Sonia, Y1 - 2019/06/11/ PY - 2019/05/13/received PY - 2019/06/06/revised PY - 2019/06/10/accepted PY - 2019/6/15/pubmed PY - 2019/6/15/medline PY - 2019/6/15/entrez KW - Antiviral resistance KW - Herpes simplex virus KW - Herpetic keratitis KW - Recombinant virus KW - Thymidine kinase SP - 183 EP - 186 JF - Antiviral research JO - Antiviral Res. VL - 168 N2 - We report here a case of an immunocompetent patient suffering from recurrent epithelial herpetic keratitis associated with the emergence of antiviral resistance. Indeed, the not previously described amino acid change L340R within herpes simplex virus thymidine kinase, was shown to confer acyclovir-resistance by recombinant phenotyping using bacmid technology. SN - 1872-9096 UR - https://www.unboundmedicine.com/medline/citation/31199933/Input_of_recombinant_phenotyping_for_the_characterization_of_a_novel_acyclovir-resistance_mutation_identified_in_a_patient_with_recurrent_herpetic_keratitis L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-3542(19)30270-0 DB - PRIME DP - Unbound Medicine ER -