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Insult-induced aberrant hippocampal neurogenesis: Functional consequences and possible therapeutic strategies.

Abstract

Adult hippocampal neurogenesis plays a critical role in a wide spectrum of hippocampus-dependent functions. Brain pathologies that involve the hippocampus like epilepsy, stroke, and traumatic brain injury, are commonly associated with cognitive impairments and mood disorders. These insults can affect neural stem cells and the subsequent neurogenic cascade in the hippocampus, resulting in the induction of aberrant neurogenesis, which is thought to compromise hippocampal network function, thereby hampering hippocampus-dependent behavior. We here summarize recent preclinical literature on hippocampal insult-induced changes in neurogenesis and based on that, we propose that normalizing aberrant neurogenesis post-insult may help to prevent or rescue behavioral deficits which could help develop novel therapeutic strategies.

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  • Authors+Show Affiliations

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    Swammerdam Institute for Life Science, Faculty of Science, University of Amsterdam, the Netherlands; University of Bordeaux, 33000 Bordeaux, France.

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    Achucarro Basque Center for Neuroscience, Spain; University of the Basque Country (UPV/EHU), Spain; University of Bordeaux, 33000 Bordeaux, France.

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    Achucarro Basque Center for Neuroscience, Spain; University of Bordeaux, 33000 Bordeaux, France.

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    Swammerdam Institute for Life Science, Faculty of Science, University of Amsterdam, the Netherlands; University of Bordeaux, 33000 Bordeaux, France.

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    KU Leuven, Department of Neurosciences and Leuven Brain Institute, Laboratory for Neurobiology and Gene Therapy, Belgium; University of Bordeaux, 33000 Bordeaux, France.

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    INSERM, U1215 NeuroCentre Magendie, 33000 Bordeaux, France; University of Bordeaux, 33000 Bordeaux, France.

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    Achucarro Basque Center for Neuroscience, Spain; IKERBASQUE, the Basque Foundation for Science, Spain; University of the Basque Country (UPV/EHU), Spain; University of Bordeaux, 33000 Bordeaux, France. Electronic address: jm.encinas@ikerbasque.org.

    Swammerdam Institute for Life Science, Faculty of Science, University of Amsterdam, the Netherlands; University of Bordeaux, 33000 Bordeaux, France. Electronic address: c.p.fitzsimons@uva.nl.

    Source

    Behavioural brain research 372: 2019 Jun 12 pg 112032

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    31199935

    Citation

    Bielefeld, P, et al. "Insult-induced Aberrant Hippocampal Neurogenesis: Functional Consequences and Possible Therapeutic Strategies." Behavioural Brain Research, vol. 372, 2019, p. 112032.
    Bielefeld P, Durá I, Danielewicz J, et al. Insult-induced aberrant hippocampal neurogenesis: Functional consequences and possible therapeutic strategies. Behav Brain Res. 2019;372:112032.
    Bielefeld, P., Durá, I., Danielewicz, J., Lucassen, P. J., Baekelandt, V., Abrous, D. N., ... Fitzsimons, C. P. (2019). Insult-induced aberrant hippocampal neurogenesis: Functional consequences and possible therapeutic strategies. Behavioural Brain Research, 372, p. 112032. doi:10.1016/j.bbr.2019.112032.
    Bielefeld P, et al. Insult-induced Aberrant Hippocampal Neurogenesis: Functional Consequences and Possible Therapeutic Strategies. Behav Brain Res. 2019 Jun 12;372:112032. PubMed PMID: 31199935.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Insult-induced aberrant hippocampal neurogenesis: Functional consequences and possible therapeutic strategies. AU - Bielefeld,P, AU - Durá,I, AU - Danielewicz,J, AU - Lucassen,P J, AU - Baekelandt,V, AU - Abrous,D N, AU - Encinas,J M, AU - Fitzsimons,C P, Y1 - 2019/06/12/ PY - 2019/04/14/received PY - 2019/05/29/revised PY - 2019/06/10/accepted PY - 2019/6/15/pubmed PY - 2019/6/15/medline PY - 2019/6/15/entrez KW - Epilepsy KW - Hippocampus KW - Neural stem cells KW - Neurogenesis KW - Stroke KW - Traumatic brain injury SP - 112032 EP - 112032 JF - Behavioural brain research JO - Behav. Brain Res. VL - 372 N2 - Adult hippocampal neurogenesis plays a critical role in a wide spectrum of hippocampus-dependent functions. Brain pathologies that involve the hippocampus like epilepsy, stroke, and traumatic brain injury, are commonly associated with cognitive impairments and mood disorders. These insults can affect neural stem cells and the subsequent neurogenic cascade in the hippocampus, resulting in the induction of aberrant neurogenesis, which is thought to compromise hippocampal network function, thereby hampering hippocampus-dependent behavior. We here summarize recent preclinical literature on hippocampal insult-induced changes in neurogenesis and based on that, we propose that normalizing aberrant neurogenesis post-insult may help to prevent or rescue behavioral deficits which could help develop novel therapeutic strategies. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/31199935/Insult-induced_aberrant_hippocampal_neurogenesis:_functional_consequences_and_possible_therapeutic_strategies L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(19)30578-9 DB - PRIME DP - Unbound Medicine ER -