Tags

Type your tag names separated by a space and hit enter

The effect of anti-emetic drugs on rat embryonic heart activity.
Reprod Toxicol 2019; 87:140-145RT

Abstract

Nausea and vomiting of pregnancy (NVP) is the most common medical complaint during pregnancy affecting up to 70% of pregnant women worldwide. Some antiemetic medications (AEM) (droperidol, domperidone, granisetron, metoclopramide and trifluoperazine) used to treat NVP have the unwanted side effect of hERG blockade. The hERG potassium channel is essential for normal heart rhythm in both the adult human and the human and rat embryo. Animal studies show hERG blockade in the embryo causes bradycardia and arrhythmia leading to cardiovascular malformations and other birth defects. Whole rat embryo in vitro culture was used to determine the effect of the above listed AEM and meclizine on the heart rate of Gestational day 13 rat embryos. These embryos are similar in size and heart development to 5-6-week human embryo. The results showed that all of the AEMs caused a concentration-dependent bradycardia. Droperidol had the lowest margin of safety.

Authors+Show Affiliations

Discipline of Anatomy and Histology, Sydney School of Medical Science, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: helen.ritchie@sydney.edu.au.Discipline of Anatomy and Histology, Sydney School of Medical Science, The University of Sydney, Sydney, NSW 2006, Australia.Discipline of Anatomy and Histology, Sydney School of Medical Science, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: bill.webster@sydney.edu.au.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31199962

Citation

Ritchie, Helen E., et al. "The Effect of Anti-emetic Drugs On Rat Embryonic Heart Activity." Reproductive Toxicology (Elmsford, N.Y.), vol. 87, 2019, pp. 140-145.
Ritchie HE, Huss IB, Webster WS. The effect of anti-emetic drugs on rat embryonic heart activity. Reprod Toxicol. 2019;87:140-145.
Ritchie, H. E., Huss, I. B., & Webster, W. S. (2019). The effect of anti-emetic drugs on rat embryonic heart activity. Reproductive Toxicology (Elmsford, N.Y.), 87, pp. 140-145. doi:10.1016/j.reprotox.2019.06.002.
Ritchie HE, Huss IB, Webster WS. The Effect of Anti-emetic Drugs On Rat Embryonic Heart Activity. Reprod Toxicol. 2019;87:140-145. PubMed PMID: 31199962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of anti-emetic drugs on rat embryonic heart activity. AU - Ritchie,Helen E, AU - Huss,Isabelle Broström, AU - Webster,William S, Y1 - 2019/06/11/ PY - 2018/12/13/received PY - 2019/06/05/revised PY - 2019/06/10/accepted PY - 2019/6/15/pubmed PY - 2019/6/15/medline PY - 2019/6/15/entrez KW - Anti-emetic drugs KW - Domperidone KW - Droperidol KW - Early pregnancy KW - Embryonic death KW - Embryonic heart rate KW - Granisetron KW - Metoclopramide KW - Trifluoperazine SP - 140 EP - 145 JF - Reproductive toxicology (Elmsford, N.Y.) JO - Reprod. Toxicol. VL - 87 N2 - Nausea and vomiting of pregnancy (NVP) is the most common medical complaint during pregnancy affecting up to 70% of pregnant women worldwide. Some antiemetic medications (AEM) (droperidol, domperidone, granisetron, metoclopramide and trifluoperazine) used to treat NVP have the unwanted side effect of hERG blockade. The hERG potassium channel is essential for normal heart rhythm in both the adult human and the human and rat embryo. Animal studies show hERG blockade in the embryo causes bradycardia and arrhythmia leading to cardiovascular malformations and other birth defects. Whole rat embryo in vitro culture was used to determine the effect of the above listed AEM and meclizine on the heart rate of Gestational day 13 rat embryos. These embryos are similar in size and heart development to 5-6-week human embryo. The results showed that all of the AEMs caused a concentration-dependent bradycardia. Droperidol had the lowest margin of safety. SN - 1873-1708 UR - https://www.unboundmedicine.com/medline/citation/31199962/The_effect_of_anti-emetic_drugs_on_rat_embryonic_heart_activity L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-6238(18)30664-6 DB - PRIME DP - Unbound Medicine ER -