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Assessment of hypolipidemic, anti-inflammatory and antioxidant properties of medicinal plant Erica multiflora in triton WR-1339-induced hyperlipidemia and liver function repair in rats: A comparison with fenofibrate.

Abstract

Hyperlipidemia is a serious health threat that has been linked to oxidative stress and systemic inflammation, causing among many other disorders essentially liver disease. The current study was conducted to evaluate the antihyperlipidemic, antioxidant and anti-inflammatory potential of methanol leaf extract from Erica multiflora (M-EML). Triton WR-1339-induced hyperlipidemic rats were divided into six groups: control group (CG), hyperlipidemic group (300 mg/kg body weight "BW") (HG), hyperlipidemic group treated with M-EML (150 and 250 mg/kg) (HG + M-EML), normal rats treated with M-EML (250 mg/kg) and fenofibrate-treated group (HG + FF) (65 mg/kg). After 24 h of administration, triton WR-1339 induced a significant increase in lipid profile, atherogenic index (AI) and Coronary Risk Index (CRI) in HG group compared to control group. Furthermore, triton WR-1339 administration induced alteration in the status of pro-inflammatory markers (aspartate transaminase, alanine transaminase, IFN-γ and Nitric oxide production). HG group showed also, a high level of lipid peroxidation, an altered antioxidant enzyme profiles and an increase in DNA damages, in liver. However, orally administration of M-EML mitigates significantly these disorders, proving hence a protective potential against triton WR-1339-induced hyperlipidemia. These findings suggest that M-EML extract could be used as functional foods and natural adjuvant treatment of hyperlipidemia.

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  • Authors+Show Affiliations

    ,

    Unity of Bioactive and Natural Substances and Biotechnology UR17ES49, Faculty of Dental Medicine, University of Monastir, Avicenna Street, 5000, Monastir, Tunisia; Higher Institute of Biotechnology of Monastir, University of Monastir, Avenue Tahar Hadded, BP 74, 5000, Monastir, Tunisia. Electronic address: rihabkhlifi@gmail.com.

    ,

    Unity of Bioactive and Natural Substances and Biotechnology UR17ES49, Faculty of Dental Medicine, University of Monastir, Avicenna Street, 5000, Monastir, Tunisia; Faculty of Pharmacy, University of Monastir, Avicenna Street, 5000, Monastir, Tunisia.

    ,

    Unity of Bioactive and Natural Substances and Biotechnology UR17ES49, Faculty of Dental Medicine, University of Monastir, Avicenna Street, 5000, Monastir, Tunisia; Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.

    ,

    Unity of Bioactive and Natural Substances and Biotechnology UR17ES49, Faculty of Dental Medicine, University of Monastir, Avicenna Street, 5000, Monastir, Tunisia; Faculty of Pharmacy, University of Monastir, Avicenna Street, 5000, Monastir, Tunisia.

    ,

    Unity of Bioactive and Natural Substances and Biotechnology UR17ES49, Faculty of Dental Medicine, University of Monastir, Avicenna Street, 5000, Monastir, Tunisia; Faculty of Pharmacy, University of Monastir, Avicenna Street, 5000, Monastir, Tunisia.

    ,

    Unity of Bioactive and Natural Substances and Biotechnology UR17ES49, Faculty of Dental Medicine, University of Monastir, Avicenna Street, 5000, Monastir, Tunisia; Faculty of Pharmacy, University of Monastir, Avicenna Street, 5000, Monastir, Tunisia.

    ,

    Faculty of Pharmacy, University of Monastir, Avicenna Street, 5000, Monastir, Tunisia.

    Unity of Bioactive and Natural Substances and Biotechnology UR17ES49, Faculty of Dental Medicine, University of Monastir, Avicenna Street, 5000, Monastir, Tunisia.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31199997

    Citation

    Khlifi, Rihab, et al. "Assessment of Hypolipidemic, Anti-inflammatory and Antioxidant Properties of Medicinal Plant Erica Multiflora in Triton WR-1339-induced Hyperlipidemia and Liver Function Repair in Rats: a Comparison With Fenofibrate." Regulatory Toxicology and Pharmacology : RTP, vol. 107, 2019, p. 104404.
    Khlifi R, Lahmar A, Dhaouefi Z, et al. Assessment of hypolipidemic, anti-inflammatory and antioxidant properties of medicinal plant Erica multiflora in triton WR-1339-induced hyperlipidemia and liver function repair in rats: A comparison with fenofibrate. Regul Toxicol Pharmacol. 2019;107:104404.
    Khlifi, R., Lahmar, A., Dhaouefi, Z., Kalboussi, Z., Maatouk, M., Kilani-Jaziri, S., ... Chekir-Ghedira, L. (2019). Assessment of hypolipidemic, anti-inflammatory and antioxidant properties of medicinal plant Erica multiflora in triton WR-1339-induced hyperlipidemia and liver function repair in rats: A comparison with fenofibrate. Regulatory Toxicology and Pharmacology : RTP, 107, p. 104404. doi:10.1016/j.yrtph.2019.104404.
    Khlifi R, et al. Assessment of Hypolipidemic, Anti-inflammatory and Antioxidant Properties of Medicinal Plant Erica Multiflora in Triton WR-1339-induced Hyperlipidemia and Liver Function Repair in Rats: a Comparison With Fenofibrate. Regul Toxicol Pharmacol. 2019 Jun 11;107:104404. PubMed PMID: 31199997.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Assessment of hypolipidemic, anti-inflammatory and antioxidant properties of medicinal plant Erica multiflora in triton WR-1339-induced hyperlipidemia and liver function repair in rats: A comparison with fenofibrate. AU - Khlifi,Rihab, AU - Lahmar,Aida, AU - Dhaouefi,Zaineb, AU - Kalboussi,Zahar, AU - Maatouk,Mouna, AU - Kilani-Jaziri,Soumaya, AU - Ghedira,Kamel, AU - Chekir-Ghedira,Leila, Y1 - 2019/06/11/ PY - 2019/02/12/received PY - 2019/05/09/revised PY - 2019/06/10/accepted PY - 2019/6/15/pubmed PY - 2019/6/15/medline PY - 2019/6/15/entrez KW - Cardiovascular problems KW - Erica multiflora KW - Lipid profile KW - Liver functions KW - Triton WR-1339 SP - 104404 EP - 104404 JF - Regulatory toxicology and pharmacology : RTP JO - Regul. Toxicol. Pharmacol. VL - 107 N2 - Hyperlipidemia is a serious health threat that has been linked to oxidative stress and systemic inflammation, causing among many other disorders essentially liver disease. The current study was conducted to evaluate the antihyperlipidemic, antioxidant and anti-inflammatory potential of methanol leaf extract from Erica multiflora (M-EML). Triton WR-1339-induced hyperlipidemic rats were divided into six groups: control group (CG), hyperlipidemic group (300 mg/kg body weight "BW") (HG), hyperlipidemic group treated with M-EML (150 and 250 mg/kg) (HG + M-EML), normal rats treated with M-EML (250 mg/kg) and fenofibrate-treated group (HG + FF) (65 mg/kg). After 24 h of administration, triton WR-1339 induced a significant increase in lipid profile, atherogenic index (AI) and Coronary Risk Index (CRI) in HG group compared to control group. Furthermore, triton WR-1339 administration induced alteration in the status of pro-inflammatory markers (aspartate transaminase, alanine transaminase, IFN-γ and Nitric oxide production). HG group showed also, a high level of lipid peroxidation, an altered antioxidant enzyme profiles and an increase in DNA damages, in liver. However, orally administration of M-EML mitigates significantly these disorders, proving hence a protective potential against triton WR-1339-induced hyperlipidemia. These findings suggest that M-EML extract could be used as functional foods and natural adjuvant treatment of hyperlipidemia. SN - 1096-0295 UR - https://www.unboundmedicine.com/medline/citation/31199997/Assessment_of_hypolipidemic,_anti-inflammatory_and_antioxidant_properties_of_medicinal_plant_Erica_multiflora_in_triton_WR-1339-induced_hyperlipidemia_and_liver_function_repair_in_rats:_A_comparison_with_fenofibrate L2 - https://linkinghub.elsevier.com/retrieve/pii/S0273-2300(19)30166-7 DB - PRIME DP - Unbound Medicine ER -