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Adaptive amino acid substitutions enhance the virulence of an avian-origin H6N1 influenza virus in mice.
Infect Genet Evol 2019; 74:103918IG

Abstract

The H6N1 subtype avian influenza virus (AIV) is a zoonotic infectious disease pathogen, which poses a threat to human health. In order to study the possible substitution of H6N1 AIV for mammals, an avian-origin H6N1 virus was successively passaged in mice. The results showed that PB2 (L193H and E627K), PA (S709F) and HA (V127I) proteins had multiple amino acid substitutions. The virulence of the mouse-adapted virus was stronger than that of the wild virus, and it was highly pathogenic to mice. Therefore, continued surveillance of these substitutions in poultry H6N1 viruses is required.

Authors+Show Affiliations

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003 Hangzhou, China.State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003 Hangzhou, China.State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003 Hangzhou, China.State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003 Hangzhou, China.State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003 Hangzhou, China.State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003 Hangzhou, China. Electronic address: flwnp@zju.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31200112

Citation

Wu, Haibo, et al. "Adaptive Amino Acid Substitutions Enhance the Virulence of an Avian-origin H6N1 Influenza Virus in Mice." Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, vol. 74, 2019, p. 103918.
Wu H, Yang F, Xiao Y, et al. Adaptive amino acid substitutions enhance the virulence of an avian-origin H6N1 influenza virus in mice. Infect Genet Evol. 2019;74:103918.
Wu, H., Yang, F., Xiao, Y., Liu, F., Yao, H., & Wu, N. (2019). Adaptive amino acid substitutions enhance the virulence of an avian-origin H6N1 influenza virus in mice. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, 74, p. 103918. doi:10.1016/j.meegid.2019.103918.
Wu H, et al. Adaptive Amino Acid Substitutions Enhance the Virulence of an Avian-origin H6N1 Influenza Virus in Mice. Infect Genet Evol. 2019;74:103918. PubMed PMID: 31200112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adaptive amino acid substitutions enhance the virulence of an avian-origin H6N1 influenza virus in mice. AU - Wu,Haibo, AU - Yang,Fan, AU - Xiao,Yixin, AU - Liu,Fumin, AU - Yao,Hangping, AU - Wu,Nanping, Y1 - 2019/06/12/ PY - 2019/04/02/received PY - 2019/05/23/revised PY - 2019/06/11/accepted PY - 2019/6/15/pubmed PY - 2019/6/15/medline PY - 2019/6/15/entrez KW - Avian influenza virus KW - H6N1 KW - Mouse-adapted KW - Substitutions KW - Virulence SP - 103918 EP - 103918 JF - Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases JO - Infect. Genet. Evol. VL - 74 N2 - The H6N1 subtype avian influenza virus (AIV) is a zoonotic infectious disease pathogen, which poses a threat to human health. In order to study the possible substitution of H6N1 AIV for mammals, an avian-origin H6N1 virus was successively passaged in mice. The results showed that PB2 (L193H and E627K), PA (S709F) and HA (V127I) proteins had multiple amino acid substitutions. The virulence of the mouse-adapted virus was stronger than that of the wild virus, and it was highly pathogenic to mice. Therefore, continued surveillance of these substitutions in poultry H6N1 viruses is required. SN - 1567-7257 UR - https://www.unboundmedicine.com/medline/citation/31200112/Adaptive_amino_acid_substitutions_enhance_the_virulence_of_an_avian-origin_H6N1_influenza_virus_in_mice L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-1348(19)30139-X DB - PRIME DP - Unbound Medicine ER -