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Behaviour and cardiac response to stress in signal crayfish exposed to environmental concentrations of tramadol.

Abstract

Evidence of the ecological and biological impact of pharmaceuticals in surface waters on aquatic organisms is increasing. Tramadol is a synthetic opioid analgesic used to treat chronic and acute pain. To investigate its long-term effects at environmentally relevant levels, we evaluated heart rate (HR) and locomotion of signal crayfish Pacifastacus leniusculus during a 21-day exposure to 1 μg L-1 tramadol followed by 14 days depuration. Locomotion and HR were recorded over a period 30 min before and 30 min after exposure to physiological fluids of an injured conspecific, a natural stressor, four times during the tramadol exposure and four times during depuration. A significant increase in HR following stress induction was found in the majority of tramadol-exposed and control crayfish, as well as significant group-specific HR changes between both groups. Locomotor activity during tramadol treatment differed from that during depuration, in general showing less time spent in locomotion and lower distance moved. The tramadol exposed crayfish exhibited higher velocity during depuration than during the exposure period. Results may suggest a potential shift in prey-predator relationships.

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  • Authors+Show Affiliations

    ,

    University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodňany, Czech Republic Zátiší 728/II 389 25 Vodňany Czech Republic. Electronic address: lozekf@jcu.cz.

    ,

    University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodňany, Czech Republic Zátiší 728/II 389 25 Vodňany Czech Republic.

    ,

    University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodňany, Czech Republic Zátiší 728/II 389 25 Vodňany Czech Republic.

    ,

    University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodňany, Czech Republic Zátiší 728/II 389 25 Vodňany Czech Republic.

    ,

    University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodňany, Czech Republic Zátiší 728/II 389 25 Vodňany Czech Republic.

    ,

    University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodňany, Czech Republic Zátiší 728/II 389 25 Vodňany Czech Republic.

    ,

    University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodňany, Czech Republic Zátiší 728/II 389 25 Vodňany Czech Republic.

    ,

    University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodňany, Czech Republic Zátiší 728/II 389 25 Vodňany Czech Republic.

    University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodňany, Czech Republic Zátiší 728/II 389 25 Vodňany Czech Republic.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31200331

    Citation

    Ložek, F, et al. "Behaviour and Cardiac Response to Stress in Signal Crayfish Exposed to Environmental Concentrations of Tramadol." Aquatic Toxicology (Amsterdam, Netherlands), vol. 213, 2019, p. 105217.
    Ložek F, Kuklina I, Grabicová K, et al. Behaviour and cardiac response to stress in signal crayfish exposed to environmental concentrations of tramadol. Aquat Toxicol. 2019;213:105217.
    Ložek, F., Kuklina, I., Grabicová, K., Kubec, J., Buřič, M., Grabic, R., ... Kozák, P. (2019). Behaviour and cardiac response to stress in signal crayfish exposed to environmental concentrations of tramadol. Aquatic Toxicology (Amsterdam, Netherlands), 213, p. 105217. doi:10.1016/j.aquatox.2019.05.019.
    Ložek F, et al. Behaviour and Cardiac Response to Stress in Signal Crayfish Exposed to Environmental Concentrations of Tramadol. Aquat Toxicol. 2019;213:105217. PubMed PMID: 31200331.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Behaviour and cardiac response to stress in signal crayfish exposed to environmental concentrations of tramadol. AU - Ložek,F, AU - Kuklina,I, AU - Grabicová,K, AU - Kubec,J, AU - Buřič,M, AU - Grabic,R, AU - Randák,T, AU - Císař,P, AU - Kozák,P, Y1 - 2019/05/31/ PY - 2019/03/20/received PY - 2019/05/20/revised PY - 2019/05/30/accepted PY - 2019/6/15/pubmed PY - 2019/6/15/medline PY - 2019/6/15/entrez KW - Analgesic KW - Aquatic organism KW - Cardiac physiology KW - Crayfish KW - Ethology KW - Invertebrate KW - Pharmaceutical pollution KW - Predation risk SP - 105217 EP - 105217 JF - Aquatic toxicology (Amsterdam, Netherlands) JO - Aquat. Toxicol. VL - 213 N2 - Evidence of the ecological and biological impact of pharmaceuticals in surface waters on aquatic organisms is increasing. Tramadol is a synthetic opioid analgesic used to treat chronic and acute pain. To investigate its long-term effects at environmentally relevant levels, we evaluated heart rate (HR) and locomotion of signal crayfish Pacifastacus leniusculus during a 21-day exposure to 1 μg L-1 tramadol followed by 14 days depuration. Locomotion and HR were recorded over a period 30 min before and 30 min after exposure to physiological fluids of an injured conspecific, a natural stressor, four times during the tramadol exposure and four times during depuration. A significant increase in HR following stress induction was found in the majority of tramadol-exposed and control crayfish, as well as significant group-specific HR changes between both groups. Locomotor activity during tramadol treatment differed from that during depuration, in general showing less time spent in locomotion and lower distance moved. The tramadol exposed crayfish exhibited higher velocity during depuration than during the exposure period. Results may suggest a potential shift in prey-predator relationships. SN - 1879-1514 UR - https://www.unboundmedicine.com/medline/citation/31200331/Behaviour_and_cardiac_response_to_stress_in_signal_crayfish_exposed_to_environmental_concentrations_of_tramadol L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-445X(19)30202-4 DB - PRIME DP - Unbound Medicine ER -