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Prevalence and comorbidity of autism spectrum disorder in Spain: study protocol for a systematic review and meta-analysis of observational studies.
Syst Rev. 2019 06 14; 8(1):141.SR

Abstract

BACKGROUND

Autism spectrum disorder (ASD) is a complex developmental disorder characterised by impaired social interaction and communication, and restrictive and repetitive behaviour. Previous systematic reviews have traditionally assessed the prevalence of ASD on global or regional context, with very few meta-analyses at the country level. The objective of this study will be to systematically evaluate published and unpublished observational studies that present prevalence and comorbidity of ASD among children, adolescent and adult population in Spain.

METHODS/DESIGN

We designed and registered a study protocol for a systematic review and meta-analysis of descriptive epidemiology data. Observational studies (cohort, cross-sectional) reporting the prevalence of ASD and conducted in a wide range of people (e.g. general population, outpatient and/or school settings) will be included. The primary outcome will be the prevalence of ASD. Secondary outcomes will be the prevalence of any physical or mental comorbidity in association with ASD. No limitations will be imposed on publication status, study conduct period, and language of dissemination. Comprehensive literature searches will be conducted in seven electronic databases (from January 1980 onwards), including PubMed/MEDLINE, EMBASE, Scopus, Web of Science, PsycINFO, IME-Spanish Medical Index and IBECS-Spanish Bibliographic Index of Health Sciences. Grey literature will be identified through searching dissertation databases, Google Scholar and conference abstracts. Two team members will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The study methodological quality (or bias) will be appraised using an appropriate tool. If feasible, we will conduct random effects meta-analysis of observational data. Prevalence estimates will be stratified according to gender, age and geographical location. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g. methodological quality, sample size, diagnostic criteria).

DISCUSSION

This systematic review and meta-analysis of observational data will identify, evaluate and integrate the epidemiological knowledge underlying the prevalence of ASD in Spain. The results of this study will be of interest to multiple audiences including patients, their families, caregivers, healthcare professional, scientists and policy makers. Results will be published in a peer-reviewed journal. Implications for future epidemiological research will be discussed.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO CRD42018090372.

Links

PMC Free PDF

Authors+Show Affiliations

Catalá-López F
Department of Health Planning and Economics, National School of Public Health, Institute of Health Carlos III, Madrid, Spain. ferran_catala@outlook.com. Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain. ferran_catala@outlook.com.
Ridao M
Instituto Aragonés de Ciencias de la Salud (IACS), Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Zaragoza, Spain.
Hurtado I
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Salud Pública), Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Valencia, Spain.
Núñez-Beltrán A
Independent Clinical Psychologist and Researcher, Madrid, Spain.
Gènova-Maleras R
Directorate General for Public Health, Madrid Regional Health Council, Madrid, Spain.
Alonso-Arroyo A
Department of History of Science and Documentation, University of Valencia, Valencia, Spain. Information and Social and Health Research Unit (UISYS), University of Valencia and Spanish National Research Council (CSIC), Valencia, Spain.
Tobías A
Spanish National Research Council (CSIC), Barcelona, Spain.
Aleixandre-Benavent R
Information and Social and Health Research Unit (UISYS), University of Valencia and Spanish National Research Council (CSIC), Valencia, Spain. Institute for Innovation and Knowledge Management (INGENIO)/Spanish National Research Council (CSIC) and Polytechnic University of Valencia (UPV), Valencia, Spain.
Catalá MA
Faculty of Medicine, University of Valencia, Valencia, Spain.
Tabarés-Seisdedos R
Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain.

MeSH

AdolescentAdultAutism Spectrum DisorderChildComorbidityHumansObservational Studies as TopicPrevalenceSpainYoung Adult

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

31200773

Citation

Catalá-López, Ferrán, et al. "Prevalence and Comorbidity of Autism Spectrum Disorder in Spain: Study Protocol for a Systematic Review and Meta-analysis of Observational Studies." Systematic Reviews, vol. 8, no. 1, 2019, p. 141.
Catalá-López F, Ridao M, Hurtado I, et al. Prevalence and comorbidity of autism spectrum disorder in Spain: study protocol for a systematic review and meta-analysis of observational studies. Syst Rev. 2019;8(1):141.
Catalá-López, F., Ridao, M., Hurtado, I., Núñez-Beltrán, A., Gènova-Maleras, R., Alonso-Arroyo, A., Tobías, A., Aleixandre-Benavent, R., Catalá, M. A., & Tabarés-Seisdedos, R. (2019). Prevalence and comorbidity of autism spectrum disorder in Spain: study protocol for a systematic review and meta-analysis of observational studies. Systematic Reviews, 8(1), 141. https://doi.org/10.1186/s13643-019-1061-1
Catalá-López F, et al. Prevalence and Comorbidity of Autism Spectrum Disorder in Spain: Study Protocol for a Systematic Review and Meta-analysis of Observational Studies. Syst Rev. 2019 06 14;8(1):141. PubMed PMID: 31200773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and comorbidity of autism spectrum disorder in Spain: study protocol for a systematic review and meta-analysis of observational studies. AU - Catalá-López,Ferrán, AU - Ridao,Manuel, AU - Hurtado,Isabel, AU - Núñez-Beltrán,Amparo, AU - Gènova-Maleras,Ricard, AU - Alonso-Arroyo,Adolfo, AU - Tobías,Aurelio, AU - Aleixandre-Benavent,Rafael, AU - Catalá,Miguel A, AU - Tabarés-Seisdedos,Rafael, Y1 - 2019/06/14/ PY - 2018/03/11/received PY - 2019/06/04/accepted PY - 2019/6/16/entrez PY - 2019/6/16/pubmed PY - 2020/7/28/medline KW - Autism spectrum disorder KW - Comorbidity KW - Epidemiological study KW - Meta-analysis KW - Prevalence KW - Spain KW - Systematic review SP - 141 EP - 141 JF - Systematic reviews JO - Syst Rev VL - 8 IS - 1 N2 - BACKGROUND: Autism spectrum disorder (ASD) is a complex developmental disorder characterised by impaired social interaction and communication, and restrictive and repetitive behaviour. Previous systematic reviews have traditionally assessed the prevalence of ASD on global or regional context, with very few meta-analyses at the country level. The objective of this study will be to systematically evaluate published and unpublished observational studies that present prevalence and comorbidity of ASD among children, adolescent and adult population in Spain. METHODS/DESIGN: We designed and registered a study protocol for a systematic review and meta-analysis of descriptive epidemiology data. Observational studies (cohort, cross-sectional) reporting the prevalence of ASD and conducted in a wide range of people (e.g. general population, outpatient and/or school settings) will be included. The primary outcome will be the prevalence of ASD. Secondary outcomes will be the prevalence of any physical or mental comorbidity in association with ASD. No limitations will be imposed on publication status, study conduct period, and language of dissemination. Comprehensive literature searches will be conducted in seven electronic databases (from January 1980 onwards), including PubMed/MEDLINE, EMBASE, Scopus, Web of Science, PsycINFO, IME-Spanish Medical Index and IBECS-Spanish Bibliographic Index of Health Sciences. Grey literature will be identified through searching dissertation databases, Google Scholar and conference abstracts. Two team members will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The study methodological quality (or bias) will be appraised using an appropriate tool. If feasible, we will conduct random effects meta-analysis of observational data. Prevalence estimates will be stratified according to gender, age and geographical location. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g. methodological quality, sample size, diagnostic criteria). DISCUSSION: This systematic review and meta-analysis of observational data will identify, evaluate and integrate the epidemiological knowledge underlying the prevalence of ASD in Spain. The results of this study will be of interest to multiple audiences including patients, their families, caregivers, healthcare professional, scientists and policy makers. Results will be published in a peer-reviewed journal. Implications for future epidemiological research will be discussed. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42018090372. SN - 2046-4053 UR - https://www.unboundmedicine.com/medline/citation/31200773/Prevalence_and_comorbidity_of_autism_spectrum_disorder_in_Spain:_study_protocol_for_a_systematic_review_and_meta_analysis_of_observational_studies_ DB - PRIME DP - Unbound Medicine ER -
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