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Gastric parietal cell and thyroid autoantibodies in oral precancer patients.
J Formos Med Assoc. 2019 Oct; 118(10):1393-1400.JF

Abstract

BACKGROUND/PURPOSE

Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) may be present in oral mucosal disease patients. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in 131 oral precancer patients.

METHODS

Serum GPCA, TGA, and TMA levels were measured in 131 oral precancer patients including 96 oral leukoplakia, 26 oral erythroleukoplakia, and 9 oral verrucous hyperplasia patients and in 131 age- and sex-matched healthy control subjects.

RESULTS

We found that 131 oral precancer patients had higher frequencies of serum GPCA (10.7% vs. 2.3%, P = 0.012, statistically significant), TGA (4.6% vs. 2.3%, P = 0.498), and TMA (8.4% vs. 2.3%, P = 0.054, marginal significance) positivities than 131 healthy control subjects. We also found that 1 (0.8%), 6 (4.6%), and 16 (12.2%) oral precancer patients had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) autoantibody in their sera, respectively. Of 10 TGA/TMA-positive oral precancer patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 80%, 10%, and 10% of these 10 TGA/TMA-positive oral precancer patients had normal, lower, and higher serum TSH levels, respectively. We also found a significantly higher GPCA positive rate in 26 smokers consuming >20 cigarettes per day than in 61 smokers consuming ≤20 cigarettes per day (P = 0.008).

CONCLUSION

Approximately 17.6% of 131 oral precancer patients have serum GPCA/TGA/TMA positivity. Only approximately 20% of TGA/TMA-positive oral precancer patients have either hypothyroidism or hyperthyroidism.

Authors+Show Affiliations

Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan. Electronic address: hmchen51@ntuh.gov.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31200999

Citation

Wu, Yu-Hsueh, et al. "Gastric Parietal Cell and Thyroid Autoantibodies in Oral Precancer Patients." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 118, no. 10, 2019, pp. 1393-1400.
Wu YH, Wu YC, Cheng SJ, et al. Gastric parietal cell and thyroid autoantibodies in oral precancer patients. J Formos Med Assoc. 2019;118(10):1393-1400.
Wu, Y. H., Wu, Y. C., Cheng, S. J., Kuo, Y. S., Sun, A., & Chen, H. M. (2019). Gastric parietal cell and thyroid autoantibodies in oral precancer patients. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 118(10), 1393-1400. https://doi.org/10.1016/j.jfma.2019.05.017
Wu YH, et al. Gastric Parietal Cell and Thyroid Autoantibodies in Oral Precancer Patients. J Formos Med Assoc. 2019;118(10):1393-1400. PubMed PMID: 31200999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric parietal cell and thyroid autoantibodies in oral precancer patients. AU - Wu,Yu-Hsueh, AU - Wu,Yang-Che, AU - Cheng,Shih-Jung, AU - Kuo,Ying-Shiung, AU - Sun,Andy, AU - Chen,Hsin-Ming, Y1 - 2019/06/11/ PY - 2019/04/30/received PY - 2019/05/21/accepted PY - 2019/6/16/pubmed PY - 2020/2/25/medline PY - 2019/6/16/entrez KW - Gastric parietal cell antibody KW - Oral leukoplakia KW - Oral precancer KW - Thyroglobulin antibody KW - Thyroid microsomal antibody SP - 1393 EP - 1400 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 118 IS - 10 N2 - BACKGROUND/PURPOSE: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) may be present in oral mucosal disease patients. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in 131 oral precancer patients. METHODS: Serum GPCA, TGA, and TMA levels were measured in 131 oral precancer patients including 96 oral leukoplakia, 26 oral erythroleukoplakia, and 9 oral verrucous hyperplasia patients and in 131 age- and sex-matched healthy control subjects. RESULTS: We found that 131 oral precancer patients had higher frequencies of serum GPCA (10.7% vs. 2.3%, P = 0.012, statistically significant), TGA (4.6% vs. 2.3%, P = 0.498), and TMA (8.4% vs. 2.3%, P = 0.054, marginal significance) positivities than 131 healthy control subjects. We also found that 1 (0.8%), 6 (4.6%), and 16 (12.2%) oral precancer patients had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) autoantibody in their sera, respectively. Of 10 TGA/TMA-positive oral precancer patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 80%, 10%, and 10% of these 10 TGA/TMA-positive oral precancer patients had normal, lower, and higher serum TSH levels, respectively. We also found a significantly higher GPCA positive rate in 26 smokers consuming >20 cigarettes per day than in 61 smokers consuming ≤20 cigarettes per day (P = 0.008). CONCLUSION: Approximately 17.6% of 131 oral precancer patients have serum GPCA/TGA/TMA positivity. Only approximately 20% of TGA/TMA-positive oral precancer patients have either hypothyroidism or hyperthyroidism. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/31200999/Gastric_parietal_cell_and_thyroid_autoantibodies_in_oral_precancer_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(19)30393-6 DB - PRIME DP - Unbound Medicine ER -