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Immunohistochemical Cross-Reactivity Between Arthrographis kalrae and Highly Pathogenic Coccidioides posadasii, Histoplasma capsulatum, and Paracoccidioides Fungal Species.
Mycopathologia. 2019 Jun; 184(3):393-402.M

Abstract

Recently, we have reported serological cross-reactivity between paracoccidioidomycosis ceti and paracoccidioidomycosis, histoplasmosis, and coccidioidomycosis. However, data on the interaction of Arthrographis kalrae with the above pathogenic fungal infections are lacking. A. kalrae is a widely occurring ascomycetous fungus; causes superficial and deep mycoses; shows thermally dependent dimorphism; and has a genomic profile related to the above-mentioned fungal species. Our study aims to investigate cross-reactivity using eight murine sera, obtained from experimental infection with two A. kalrae isolates. The murine sera were incubated with fungal cells of A. kalrae, Coccidioides posadasii, Histoplasma capsulatum, Paracoccidioides sp., and P. brasiliensis. Thirty murine sera, obtained from experimental infection with six isolates of H. capsulatum, sera from three cases of dolphin paracoccidioidomycosis ceti, two human sera from patients with paracoccidioidomycosis, and a serum sample from a healthy person with a history of coccidioidomycosis, were also incubated with A. kalrae fungal cells and the respective fungal cells that caused the infection as positive controls. Sera derived from the mice infected with A. kalrae reacted strongly when incubated with the Paracoccidioides sp., P. brasiliensis, and C. posadasii, but no positive reaction was observed against the fungal cells of H. capsulatum. The murine sera infected with three out of six isolates of H. capsulatum, and all cetacean and human serum samples reacted positively with the fungal cells of A. kalrae. The present study demonstrated serological cross-reactions among A. kalrae infection, coccidioidomycosis, paracoccidioidomycosis, paracoccidioidomycosis ceti, and histoplasmosis.

Authors+Show Affiliations

Ryukyu Animal Medical Center, Yone 5-27, Tomigusuku, Okinawa, 901-0224, Japan. The United Graduate School of Agriculture Sciences, Kagoshima University, Kagoshima, 890-0065, Japan. Department of Animal Sciences, Faculty of Agriculture, University of the Ryukyus, Sembaru 1, Nishihara-Cho, Nakagusuku-Gun, Okinawa, 903-0213, Japan.Institute of Technology of Parana, Rua Joao Americo de Oliveira, 330, Curitiba, PR, 80030-060, Brazil.Department of Pathological Science, CCB, State University of Londrina, P.O. Box 6001, Londrina, PR, 86051-970, Brazil.Okinawa Churashima Foundation, Aza Ishikawa 888, Motobu-Cho, Kunigami-Gun, Okinawa, 905-0206, Japan.Okinawa Churashima Foundation, Aza Ishikawa 888, Motobu-Cho, Kunigami-Gun, Okinawa, 905-0206, Japan.Ryukyu Animal Medical Center, Yone 5-27, Tomigusuku, Okinawa, 901-0224, Japan. aya_grimalkin@yahoo.co.jp. The United Graduate School of Agriculture Sciences, Kagoshima University, Kagoshima, 890-0065, Japan. aya_grimalkin@yahoo.co.jp. Department of Animal Sciences, Faculty of Agriculture, University of the Ryukyus, Sembaru 1, Nishihara-Cho, Nakagusuku-Gun, Okinawa, 903-0213, Japan. aya_grimalkin@yahoo.co.jp.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31201650

Citation

Shumoto, Godai, et al. "Immunohistochemical Cross-Reactivity Between Arthrographis Kalrae and Highly Pathogenic Coccidioides Posadasii, Histoplasma Capsulatum, and Paracoccidioides Fungal Species." Mycopathologia, vol. 184, no. 3, 2019, pp. 393-402.
Shumoto G, Nagashima LA, Itano EN, et al. Immunohistochemical Cross-Reactivity Between Arthrographis kalrae and Highly Pathogenic Coccidioides posadasii, Histoplasma capsulatum, and Paracoccidioides Fungal Species. Mycopathologia. 2019;184(3):393-402.
Shumoto, G., Nagashima, L. A., Itano, E. N., Minakawa, T., Ueda, K., & Sano, A. (2019). Immunohistochemical Cross-Reactivity Between Arthrographis kalrae and Highly Pathogenic Coccidioides posadasii, Histoplasma capsulatum, and Paracoccidioides Fungal Species. Mycopathologia, 184(3), 393-402. https://doi.org/10.1007/s11046-019-00348-5
Shumoto G, et al. Immunohistochemical Cross-Reactivity Between Arthrographis Kalrae and Highly Pathogenic Coccidioides Posadasii, Histoplasma Capsulatum, and Paracoccidioides Fungal Species. Mycopathologia. 2019;184(3):393-402. PubMed PMID: 31201650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistochemical Cross-Reactivity Between Arthrographis kalrae and Highly Pathogenic Coccidioides posadasii, Histoplasma capsulatum, and Paracoccidioides Fungal Species. AU - Shumoto,Godai, AU - Nagashima,Luciene Airy, AU - Itano,Eiko Nakagawa, AU - Minakawa,Tomoko, AU - Ueda,Keiichi, AU - Sano,Ayako, Y1 - 2019/06/14/ PY - 2019/02/12/received PY - 2019/06/05/accepted PY - 2019/6/16/pubmed PY - 2020/1/3/medline PY - 2019/6/16/entrez KW - Arthrographis kalrae KW - Coccidioidomycosis KW - Histoplasmosis KW - Paracoccidioidomycosis KW - Paracoccidioidomycosis ceti SP - 393 EP - 402 JF - Mycopathologia JO - Mycopathologia VL - 184 IS - 3 N2 - Recently, we have reported serological cross-reactivity between paracoccidioidomycosis ceti and paracoccidioidomycosis, histoplasmosis, and coccidioidomycosis. However, data on the interaction of Arthrographis kalrae with the above pathogenic fungal infections are lacking. A. kalrae is a widely occurring ascomycetous fungus; causes superficial and deep mycoses; shows thermally dependent dimorphism; and has a genomic profile related to the above-mentioned fungal species. Our study aims to investigate cross-reactivity using eight murine sera, obtained from experimental infection with two A. kalrae isolates. The murine sera were incubated with fungal cells of A. kalrae, Coccidioides posadasii, Histoplasma capsulatum, Paracoccidioides sp., and P. brasiliensis. Thirty murine sera, obtained from experimental infection with six isolates of H. capsulatum, sera from three cases of dolphin paracoccidioidomycosis ceti, two human sera from patients with paracoccidioidomycosis, and a serum sample from a healthy person with a history of coccidioidomycosis, were also incubated with A. kalrae fungal cells and the respective fungal cells that caused the infection as positive controls. Sera derived from the mice infected with A. kalrae reacted strongly when incubated with the Paracoccidioides sp., P. brasiliensis, and C. posadasii, but no positive reaction was observed against the fungal cells of H. capsulatum. The murine sera infected with three out of six isolates of H. capsulatum, and all cetacean and human serum samples reacted positively with the fungal cells of A. kalrae. The present study demonstrated serological cross-reactions among A. kalrae infection, coccidioidomycosis, paracoccidioidomycosis, paracoccidioidomycosis ceti, and histoplasmosis. SN - 1573-0832 UR - https://www.unboundmedicine.com/medline/citation/31201650/Immunohistochemical_Cross_Reactivity_Between_Arthrographis_kalrae_and_Highly_Pathogenic_Coccidioides_posadasii_Histoplasma_capsulatum_and_Paracoccidioides_Fungal_Species_ L2 - https://dx.doi.org/10.1007/s11046-019-00348-5 DB - PRIME DP - Unbound Medicine ER -