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The Potential Role of Medicinal Plants in Bone Regeneration.

Abstract

Background and Context

Natural healing of bone lesions once incomplete or delayed bone regeneration represents an important clinical issue and plants possess compounds that may enhance bone healing, and avoid bone losses.

Objective

The aim of this review is to evaluate the potential role of medicinal plants in the bone regenaration.

Methods/Design

This review has included relevant studies available in MEDLINE-PubMed in the last three years that associated the role of plants in the bone regeneration. The descriptors used were "bone regeneration and plants" and "bone regeneration and medicinal plants".

Results

We selected 59 articles, but only 15 studies dovetailed the study objectives of this review. These studies showed that plants have potential in increasing in the osseointegration once their components may downregulate biomarkers such as interleukin (IL)-1β, IL-6, IL-8, Tumor Necrosis Factor-α, Metalloproteinase 2, and 3. They may also upregulate mediators such as Vascular Endothelial Growth Factor, Transforming-Growing Factor-β1, Bone Morphogenetic Protein-2, osteocalcin, osteopontin, and type 1 collagen. The control in the production of these cytokines may help bone regeneration. Plant components such as curcumol, caffeic acid, resveratrol, luteolin, and many others may also be useful in bone health once may interfere in Nuclear Factor-κB and Mitogen Activated Protein Kinases, and may modulate Ca2+ signaling, inflammatory mediator genes, and inhibiting osteoclast-mediated bone resorption.

Conclusion

Many plants possess components that are effective in promoting bone regeneration and new pharmaceutical technology and pharmacological researchers should be performed in order to establish the dose and the appropriate delivery vehicle of administration of the plant or its compounds.

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Authors

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Source

MeSH

Bone Regeneration
Humans
Matrix Metalloproteinase 2
Plants, Medicinal
Vascular Endothelial Growth Factor A
Wound Healing

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31202209

Citation

Barbalho, Sandra Maria, et al. "The Potential Role of Medicinal Plants in Bone Regeneration." Alternative Therapies in Health and Medicine, vol. 25, no. 4, 2019, pp. 32-39.
Barbalho SM, Araújo AC, Penteado Detregiachi CR, et al. The Potential Role of Medicinal Plants in Bone Regeneration. Altern Ther Health Med. 2019;25(4):32-39.
Barbalho, S. M., Araújo, A. C., Penteado Detregiachi, C. R., Buchaim, D. V., & Guiguer, É. L. (2019). The Potential Role of Medicinal Plants in Bone Regeneration. Alternative Therapies in Health and Medicine, 25(4), pp. 32-39.
Barbalho SM, et al. The Potential Role of Medicinal Plants in Bone Regeneration. Altern Ther Health Med. 2019;25(4):32-39. PubMed PMID: 31202209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Potential Role of Medicinal Plants in Bone Regeneration. AU - Barbalho,Sandra Maria, AU - Araújo,Adriano Cressoni, AU - Penteado Detregiachi,Cláudia Rucco, AU - Buchaim,Daniela Vieira, AU - Guiguer,Élen Landgraf, PY - 2019/6/16/entrez PY - 2019/6/16/pubmed PY - 2019/6/20/medline SP - 32 EP - 39 JF - Alternative therapies in health and medicine JO - Altern Ther Health Med VL - 25 IS - 4 N2 - Background and Context: Natural healing of bone lesions once incomplete or delayed bone regeneration represents an important clinical issue and plants possess compounds that may enhance bone healing, and avoid bone losses. Objective: The aim of this review is to evaluate the potential role of medicinal plants in the bone regenaration. Methods/Design: This review has included relevant studies available in MEDLINE-PubMed in the last three years that associated the role of plants in the bone regeneration. The descriptors used were "bone regeneration and plants" and "bone regeneration and medicinal plants". Results: We selected 59 articles, but only 15 studies dovetailed the study objectives of this review. These studies showed that plants have potential in increasing in the osseointegration once their components may downregulate biomarkers such as interleukin (IL)-1β, IL-6, IL-8, Tumor Necrosis Factor-α, Metalloproteinase 2, and 3. They may also upregulate mediators such as Vascular Endothelial Growth Factor, Transforming-Growing Factor-β1, Bone Morphogenetic Protein-2, osteocalcin, osteopontin, and type 1 collagen. The control in the production of these cytokines may help bone regeneration. Plant components such as curcumol, caffeic acid, resveratrol, luteolin, and many others may also be useful in bone health once may interfere in Nuclear Factor-κB and Mitogen Activated Protein Kinases, and may modulate Ca2+ signaling, inflammatory mediator genes, and inhibiting osteoclast-mediated bone resorption. Conclusion: Many plants possess components that are effective in promoting bone regeneration and new pharmaceutical technology and pharmacological researchers should be performed in order to establish the dose and the appropriate delivery vehicle of administration of the plant or its compounds. SN - 1078-6791 UR - https://www.unboundmedicine.com/medline/citation/31202209/The_Potential_Role_of_Medicinal_Plants_in_Bone_Regeneration DB - PRIME DP - Unbound Medicine ER -