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Sperm Morphology: History, Challenges, and Impact on Natural and Assisted Fertility.
Curr Urol Rep 2019; 20(8):43CU

Abstract

PURPOSE OF REVIEW

The classification of morphologically normal sperm has been progressively redefined. Concurrently, our understanding of the significance of sperm morphology in relation to male factor infertility has evolved. In this review, we will discuss the evolution of sperm morphology assessment and factors that contribute to its measurement variability. We will examine the impact of sperm morphology on natural pregnancy, IUI, IVF, and ICSI outcomes.

RECENT FINDINGS

There is a lack of consensus on sperm morphology classification, technique, and inter-observer grading variability. Current evidence suggests sperm morphology has low predictive value for pregnancy success, for both natural and assisted reproduction. Additionally, the threshold for what is considered an adequate percentage of morphologically normal sperm has changed over time. These variables have called into question the relevance of this variable in predicting fertility outcomes. Our understanding of the impact of sperm morphology on reproductive outcomes continues to evolve and seems to play less of a role than initially thought.

Authors+Show Affiliations

Division of Reproductive Endocrinology, University of Southern California, 2020 Zonal Avenue, IRD 534, Los Angeles, CA, 90033, USA. Rachel.danis@med.usc.edu.Institute of Urology, University of Southern California, 1441 Eastlake Avenue, Suite 7416, Los Angeles, CA, 90089, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31203470

Citation

Danis, Rachel B., and Mary K. Samplaski. "Sperm Morphology: History, Challenges, and Impact On Natural and Assisted Fertility." Current Urology Reports, vol. 20, no. 8, 2019, p. 43.
Danis RB, Samplaski MK. Sperm Morphology: History, Challenges, and Impact on Natural and Assisted Fertility. Curr Urol Rep. 2019;20(8):43.
Danis, R. B., & Samplaski, M. K. (2019). Sperm Morphology: History, Challenges, and Impact on Natural and Assisted Fertility. Current Urology Reports, 20(8), p. 43. doi:10.1007/s11934-019-0911-7.
Danis RB, Samplaski MK. Sperm Morphology: History, Challenges, and Impact On Natural and Assisted Fertility. Curr Urol Rep. 2019 Jun 15;20(8):43. PubMed PMID: 31203470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sperm Morphology: History, Challenges, and Impact on Natural and Assisted Fertility. AU - Danis,Rachel B, AU - Samplaski,Mary K, Y1 - 2019/06/15/ PY - 2019/6/17/entrez PY - 2019/6/17/pubmed PY - 2019/9/10/medline KW - Assisted reproductive technology KW - Infertility KW - Male factor KW - Semen analysis KW - Sperm morphology KW - Teratozoospermia SP - 43 EP - 43 JF - Current urology reports JO - Curr Urol Rep VL - 20 IS - 8 N2 - PURPOSE OF REVIEW: The classification of morphologically normal sperm has been progressively redefined. Concurrently, our understanding of the significance of sperm morphology in relation to male factor infertility has evolved. In this review, we will discuss the evolution of sperm morphology assessment and factors that contribute to its measurement variability. We will examine the impact of sperm morphology on natural pregnancy, IUI, IVF, and ICSI outcomes. RECENT FINDINGS: There is a lack of consensus on sperm morphology classification, technique, and inter-observer grading variability. Current evidence suggests sperm morphology has low predictive value for pregnancy success, for both natural and assisted reproduction. Additionally, the threshold for what is considered an adequate percentage of morphologically normal sperm has changed over time. These variables have called into question the relevance of this variable in predicting fertility outcomes. Our understanding of the impact of sperm morphology on reproductive outcomes continues to evolve and seems to play less of a role than initially thought. SN - 1534-6285 UR - https://www.unboundmedicine.com/medline/citation/31203470/Sperm_Morphology:_History,_Challenges,_and_Impact_on_Natural_and_Assisted_Fertility L2 - https://dx.doi.org/10.1007/s11934-019-0911-7 DB - PRIME DP - Unbound Medicine ER -