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Regenerative medicine: the red planet for clinicians.
Intern Emerg Med 2019; 14(6):911-921IE

Abstract

Regenerative medicine represents the forefront of health sciences and holds promises for the treatment and, possibly, the cure of a number of challenging conditions. It relies on the use of stem cells, tissue engineering, and gene therapy alone or in different combinations. The goal is to deliver cells, tissues, or organs to repair, regenerate, or replace the damaged ones. Among stem-cell populations, both haematopoietic and mesenchymal stem cells have been employed in the treatment of refractory chronic inflammatory diseases with promising results. However, only mesenchymal stem cells seem advantageous as both systemic and local injections may be performed without the need for immune ablation. Recently, also induced pluripotent stem cells have been exploited for therapeutic purposes given their tremendous potential to be an unlimited source of any tissue-specific cells. Moreover, through the development of technologies that make organ fabrication possible using cells and supporting scaffolding materials, regenerative medicine promises to enable organ-on-demand, whereby patients will receive organs in a timely fashion without the risk of rejection. Finally, gene therapy is emerging as a successful strategy not only in monogenic diseases, but also in multifactorial conditions. Several of these approaches have recently received approval for commercialization, thus opening a new therapeutic era. This is why both General Practitioners and Internists should be aware of these great advancements.

Authors+Show Affiliations

Gastroenterology Unit, Department of Medicine, AOUI Policlinico G.B. Rossi and University of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy. rachele.ciccocioppo@univr.it.San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy. Vita Salute San Raffaele University, Milan, Italy.Wake Forest University School of Medicine, Winston-Salem, NC, USA.Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31203564

Citation

Ciccocioppo, Rachele, et al. "Regenerative Medicine: the Red Planet for Clinicians." Internal and Emergency Medicine, vol. 14, no. 6, 2019, pp. 911-921.
Ciccocioppo R, Cantore A, Chaimov D, et al. Regenerative medicine: the red planet for clinicians. Intern Emerg Med. 2019;14(6):911-921.
Ciccocioppo, R., Cantore, A., Chaimov, D., & Orlando, G. (2019). Regenerative medicine: the red planet for clinicians. Internal and Emergency Medicine, 14(6), pp. 911-921. doi:10.1007/s11739-019-02126-z.
Ciccocioppo R, et al. Regenerative Medicine: the Red Planet for Clinicians. Intern Emerg Med. 2019;14(6):911-921. PubMed PMID: 31203564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regenerative medicine: the red planet for clinicians. AU - Ciccocioppo,Rachele, AU - Cantore,Alessio, AU - Chaimov,Deborah, AU - Orlando,Giuseppe, Y1 - 2019/06/15/ PY - 2019/01/07/received PY - 2019/06/06/accepted PY - 2019/6/17/pubmed PY - 2019/6/17/medline PY - 2019/6/17/entrez KW - Gene therapy KW - Regenerative medicine KW - Stem cells KW - Tissue engineering SP - 911 EP - 921 JF - Internal and emergency medicine JO - Intern Emerg Med VL - 14 IS - 6 N2 - Regenerative medicine represents the forefront of health sciences and holds promises for the treatment and, possibly, the cure of a number of challenging conditions. It relies on the use of stem cells, tissue engineering, and gene therapy alone or in different combinations. The goal is to deliver cells, tissues, or organs to repair, regenerate, or replace the damaged ones. Among stem-cell populations, both haematopoietic and mesenchymal stem cells have been employed in the treatment of refractory chronic inflammatory diseases with promising results. However, only mesenchymal stem cells seem advantageous as both systemic and local injections may be performed without the need for immune ablation. Recently, also induced pluripotent stem cells have been exploited for therapeutic purposes given their tremendous potential to be an unlimited source of any tissue-specific cells. Moreover, through the development of technologies that make organ fabrication possible using cells and supporting scaffolding materials, regenerative medicine promises to enable organ-on-demand, whereby patients will receive organs in a timely fashion without the risk of rejection. Finally, gene therapy is emerging as a successful strategy not only in monogenic diseases, but also in multifactorial conditions. Several of these approaches have recently received approval for commercialization, thus opening a new therapeutic era. This is why both General Practitioners and Internists should be aware of these great advancements. SN - 1970-9366 UR - https://www.unboundmedicine.com/medline/citation/31203564/Regenerative_medicine:_the_red_planet_for_clinicians L2 - https://dx.doi.org/10.1007/s11739-019-02126-z DB - PRIME DP - Unbound Medicine ER -