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Metabolomic Insights into the Effects of Breast Milk Versus Formula Milk Feeding in Infants.

Abstract

PURPOSE OF REVIEW

This review summarizes the latest scientific evidence for the presence of metabolomic differences between infants fed breast milk (I-BM) and infants fed formula milk (I-FM).

RECENT FINDINGS

Across the studies included in this review, a total of 261 metabolites were analyzed, of which 151 metabolites were reported as significantly associated with infant feeding modality (BM versus FM). However, taken as a whole, the relevant literature was notable both for methodological limitations, such as small sample sizes, and heterogeneity between the studies. This may be why many associations between infant metabolite profile and feeding modality have not replicated across studies. To our knowledge, this is the first review to integrate the available literature on metabolomic differences between I-BM versus I-FM. This narrative review synthesized the data across studies and identified those metabolites which show the most robust associations with infant feeding modality. Methodological limitations of the current studies are identified, followed by recommendations for how to address these in future studies.

Links

Authors+Show Affiliations

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USDA / ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 Bates Street, Houston, TX, 77030, USA.

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USDA / ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 Bates Street, Houston, TX, 77030, USA.

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USDA / ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 Bates Street, Houston, TX, 77030, USA.

USDA / ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 Bates Street, Houston, TX, 77030, USA. LekkiWood@Gmail.com.

Source

Current nutrition reports : 2019 Jun 15 pg

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31203566

Citation

Phan, Mimi, et al. "Metabolomic Insights Into the Effects of Breast Milk Versus Formula Milk Feeding in Infants." Current Nutrition Reports, 2019.
Phan M, Momin SR, Senn MK, et al. Metabolomic Insights into the Effects of Breast Milk Versus Formula Milk Feeding in Infants. Curr Nutr Rep. 2019.
Phan, M., Momin, S. R., Senn, M. K., & Wood, A. C. (2019). Metabolomic Insights into the Effects of Breast Milk Versus Formula Milk Feeding in Infants. Current Nutrition Reports, doi:10.1007/s13668-019-00284-2.
Phan M, et al. Metabolomic Insights Into the Effects of Breast Milk Versus Formula Milk Feeding in Infants. Curr Nutr Rep. 2019 Jun 15; PubMed PMID: 31203566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolomic Insights into the Effects of Breast Milk Versus Formula Milk Feeding in Infants. AU - Phan,Mimi, AU - Momin,Shabnam R, AU - Senn,Mackenzie K, AU - Wood,Alexis C, Y1 - 2019/06/15/ PY - 2019/6/17/entrez PY - 2019/6/17/pubmed PY - 2019/6/17/medline KW - Breast milk KW - Breastfeeding KW - Formula milk KW - Metabolomics KW - Review JF - Current nutrition reports JO - Curr Nutr Rep N2 - PURPOSE OF REVIEW: This review summarizes the latest scientific evidence for the presence of metabolomic differences between infants fed breast milk (I-BM) and infants fed formula milk (I-FM). RECENT FINDINGS: Across the studies included in this review, a total of 261 metabolites were analyzed, of which 151 metabolites were reported as significantly associated with infant feeding modality (BM versus FM). However, taken as a whole, the relevant literature was notable both for methodological limitations, such as small sample sizes, and heterogeneity between the studies. This may be why many associations between infant metabolite profile and feeding modality have not replicated across studies. To our knowledge, this is the first review to integrate the available literature on metabolomic differences between I-BM versus I-FM. This narrative review synthesized the data across studies and identified those metabolites which show the most robust associations with infant feeding modality. Methodological limitations of the current studies are identified, followed by recommendations for how to address these in future studies. SN - 2161-3311 UR - https://www.unboundmedicine.com/medline/citation/31203566/Metabolomic_Insights_into_the_Effects_of_Breast_Milk_Versus_Formula_Milk_Feeding_in_Infants DB - PRIME DP - Unbound Medicine ER -
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