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Epimedin C protects H2O2-induced peroxidation injury by enhancing the function of endothelial progenitor HUVEC populations.

Abstract

Endothelial cell injury and apoptosis induced by oxidative stress serve important roles in many vascular diseases. The repair of endothelial cell vascular injury relies on the function of local endothelial progenitor cells (EPCs). Our previous study indicated that epimedin C, a major flavonoid derived from Herba epimedii (yin yang huo), could promote vascularization by inducing endothelial-like differentiation of mesenchymal stem cells C3H/10T1/2 both in vivo and in vitro. In view of the significant cardiovascular protective effects of Herba epimedii, we detected a protective effect of epimedin C on H2O2-induced peroxidation injury in human umbilical vein endothelial cells (HUVECs) and the role of EPC in this process. The results show that epimedin C increased the expression of the stem cell marker, CD34 and PROM1, and subsequently enhanced the expression and function of vascular endothelial growth factor and MMP-2 in local vascular endothelial cells. In conclusion, epimedin C protects H2O2-induced peroxidation injury by enhancing the function of endothelial progenitor HUVEC populations.

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  • Authors+Show Affiliations

    ,

    Danhong Wei, Department of Neuroscience Care Unit, the Second Affiliated Hospital, Zhejiang University School of Medicine.

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    Zhejiang Chinese Medical University.

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    Zhejiang Chinese Medical University.

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    Zhejiang Chinese Medical University.

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    Zhejiang Chinese Medical University.

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    Zhejiang Chinese Medical University. Five Branches University.

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    Danhong Wei, Department of Neuroscience Care Unit, the Second Affiliated Hospital, Zhejiang University School of Medicine.

    ,

    Zhejiang Chinese Medical University.

    Zhejiang Chinese Medical University.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31204351

    Citation

    Wei, Dan-Hong, et al. "Epimedin C Protects H2O2-induced Peroxidation Injury By Enhancing the Function of Endothelial Progenitor HUVEC Populations." Biological & Pharmaceutical Bulletin, 2019.
    Wei DH, Deng JL, Shi RZ, et al. Epimedin C protects H2O2-induced peroxidation injury by enhancing the function of endothelial progenitor HUVEC populations. Biol Pharm Bull. 2019.
    Wei, D. H., Deng, J. L., Shi, R. Z., Ma, L., Shen, J. M., Hoffman, R., ... Gao, J. L. (2019). Epimedin C protects H2O2-induced peroxidation injury by enhancing the function of endothelial progenitor HUVEC populations. Biological & Pharmaceutical Bulletin, doi:10.1248/bpb.b19-00159.
    Wei DH, et al. Epimedin C Protects H2O2-induced Peroxidation Injury By Enhancing the Function of Endothelial Progenitor HUVEC Populations. Biol Pharm Bull. 2019 Jun 14; PubMed PMID: 31204351.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Epimedin C protects H2O2-induced peroxidation injury by enhancing the function of endothelial progenitor HUVEC populations. AU - Wei,Dan-Hong, AU - Deng,Jiu-Ling, AU - Shi,Rong-Zhen, AU - Ma,Li, AU - Shen,Jia-Man, AU - Hoffman,Robert, AU - Hu,Ying-Hong, AU - Wang,Hui, AU - Gao,Jian-Li, Y1 - 2019/06/14/ PY - 2019/6/18/entrez KW - Chinese herbs KW - Epimedin C KW - HUVEC KW - Herba Epimdii KW - endothelial progenitor cell KW - peroxidation injury JF - Biological & pharmaceutical bulletin JO - Biol. Pharm. Bull. N2 - Endothelial cell injury and apoptosis induced by oxidative stress serve important roles in many vascular diseases. The repair of endothelial cell vascular injury relies on the function of local endothelial progenitor cells (EPCs). Our previous study indicated that epimedin C, a major flavonoid derived from Herba epimedii (yin yang huo), could promote vascularization by inducing endothelial-like differentiation of mesenchymal stem cells C3H/10T1/2 both in vivo and in vitro. In view of the significant cardiovascular protective effects of Herba epimedii, we detected a protective effect of epimedin C on H2O2-induced peroxidation injury in human umbilical vein endothelial cells (HUVECs) and the role of EPC in this process. The results show that epimedin C increased the expression of the stem cell marker, CD34 and PROM1, and subsequently enhanced the expression and function of vascular endothelial growth factor and MMP-2 in local vascular endothelial cells. In conclusion, epimedin C protects H2O2-induced peroxidation injury by enhancing the function of endothelial progenitor HUVEC populations. SN - 1347-5215 UR - https://www.unboundmedicine.com/medline/citation/31204351/Epimedin_C_protects_H2O2-induced_peroxidation_injury_by_enhancing_the_function_of_endothelial_progenitor_HUVEC_populations L2 - https://dx.doi.org/10.1248/bpb.b19-00159 DB - PRIME DP - Unbound Medicine ER -