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Measurement of intestinal permeability to mannitol and lactulose as a means of diagnosing food allergy and evaluating therapeutic effectiveness of disodium cromoglycate.
Ann Allergy. 1987 Nov; 59(5 Pt 2):127-30.AA

Abstract

Gastrointestinal permeability was evaluated in 90 fasting healthy subjects and 60 patients with food allergy by oral administration to both groups of 5 g of mannitol, a marker of absorption of small molecules, and 5 g of lactulose, a marker of abnormal absorption of large molecules, and subsequent measurement of urinary excretion of mannitol and lactulose. In healthy subjects, mean 5-hour urinary excretion of mannitol was 14.11% and of lactulose 0.26%. In the fasting state, the 60 patients with food allergy exhibited a mean urinary recovery of mannitol of 13.22%, not significantly different from that in healthy subjects. Mean recovery of lactulose in the patients with food allergy was 0.55%, significantly greater than in the healthy patients. After ingestion of food allergens by the patients, mean mannitol recovery fell to 11.57% and mean recovery of lactulose rose to 1.04%, both values being significantly different from those obtained in the fasting patients. On challenging the patients after they had taken sodium cromoglycate, mean mannitol and lactulose recoveries (13.53% and 0.62%, respectively) were not significantly different from those in fasting patients but were significantly different from those obtained on challenging patients unprotected by sodium cromoglycate. Evaluation of intestinal permeability in this way provides an objective means of diagnosing food allergy and assessing the effectiveness of anti-allergic agents such as sodium cromoglycate.

Authors+Show Affiliations

Laboratoire d'Immunopathologie Digestive INSERM, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3120628

Citation

Andre, C, et al. "Measurement of Intestinal Permeability to Mannitol and Lactulose as a Means of Diagnosing Food Allergy and Evaluating Therapeutic Effectiveness of Disodium Cromoglycate." Annals of Allergy, vol. 59, no. 5 Pt 2, 1987, pp. 127-30.
Andre C, Andre F, Colin L, et al. Measurement of intestinal permeability to mannitol and lactulose as a means of diagnosing food allergy and evaluating therapeutic effectiveness of disodium cromoglycate. Ann Allergy. 1987;59(5 Pt 2):127-30.
Andre, C., Andre, F., Colin, L., & Cavagna, S. (1987). Measurement of intestinal permeability to mannitol and lactulose as a means of diagnosing food allergy and evaluating therapeutic effectiveness of disodium cromoglycate. Annals of Allergy, 59(5 Pt 2), 127-30.
Andre C, et al. Measurement of Intestinal Permeability to Mannitol and Lactulose as a Means of Diagnosing Food Allergy and Evaluating Therapeutic Effectiveness of Disodium Cromoglycate. Ann Allergy. 1987;59(5 Pt 2):127-30. PubMed PMID: 3120628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measurement of intestinal permeability to mannitol and lactulose as a means of diagnosing food allergy and evaluating therapeutic effectiveness of disodium cromoglycate. AU - Andre,C, AU - Andre,F, AU - Colin,L, AU - Cavagna,S, PY - 1987/11/1/pubmed PY - 1987/11/1/medline PY - 1987/11/1/entrez SP - 127 EP - 30 JF - Annals of allergy JO - Ann Allergy VL - 59 IS - 5 Pt 2 N2 - Gastrointestinal permeability was evaluated in 90 fasting healthy subjects and 60 patients with food allergy by oral administration to both groups of 5 g of mannitol, a marker of absorption of small molecules, and 5 g of lactulose, a marker of abnormal absorption of large molecules, and subsequent measurement of urinary excretion of mannitol and lactulose. In healthy subjects, mean 5-hour urinary excretion of mannitol was 14.11% and of lactulose 0.26%. In the fasting state, the 60 patients with food allergy exhibited a mean urinary recovery of mannitol of 13.22%, not significantly different from that in healthy subjects. Mean recovery of lactulose in the patients with food allergy was 0.55%, significantly greater than in the healthy patients. After ingestion of food allergens by the patients, mean mannitol recovery fell to 11.57% and mean recovery of lactulose rose to 1.04%, both values being significantly different from those obtained in the fasting patients. On challenging the patients after they had taken sodium cromoglycate, mean mannitol and lactulose recoveries (13.53% and 0.62%, respectively) were not significantly different from those in fasting patients but were significantly different from those obtained on challenging patients unprotected by sodium cromoglycate. Evaluation of intestinal permeability in this way provides an objective means of diagnosing food allergy and assessing the effectiveness of anti-allergic agents such as sodium cromoglycate. SN - 0003-4738 UR - https://www.unboundmedicine.com/medline/citation/3120628/Measurement_of_intestinal_permeability_to_mannitol_and_lactulose_as_a_means_of_diagnosing_food_allergy_and_evaluating_therapeutic_effectiveness_of_disodium_cromoglycate_ L2 - https://medlineplus.gov/foodallergy.html DB - PRIME DP - Unbound Medicine ER -