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Rosmarinic acid improved antioxidant properties and healthspan via the IIS and MAPK pathways in Caenorhabditis elegans.
Biofactors. 2019 Sep; 45(5):774-787.B

Abstract

Rosmarinic acid (RA) has a wide range of biological effects, including the antioxidation and antiaging. However, the detailed mechanisms remain unclear but highly attractive. Herein, RA promoted lifespan and motoricity in a dose-dependent manner, and reduced fat store without threatening fertility in Caenorhabditis elegans. In term of antioxidant efficacy, catalase activity, glutathione peroxidas activity, reduced glutathione content, and reduced glutathione/oxidized glutathione ratio were enhanced. And malondialdehyde content was diminished significantly. Moreover, RA increased survival under acute oxidative and thermal stress, and suppressed intestinal lipofuscin accumulation. So the improvement of lifespan mediated by RA could be related with its strong antioxidant properties. Furthermore, RA was absorbed by worms. Further research in pursuit of the mechanism showed that longevity induced by RA was involved with the genes sod-3, sod-5, ctl-1, daf-16, ins-18, skn-1, and sek-1, but was independent of subcellular localization of DAF-16. These findings indicated that RA had a potential for promoting healthy lifespan.

Authors+Show Affiliations

Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, Guangdong, China.Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, Guangdong, China.Department of Laboratory Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, Guangdong, China.Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, Guangdong, China.Department of Food Science, Rutgers University, New Brunswick, New Jersey.Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, Guangdong, China.Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, Guangdong, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31206890

Citation

Lin, Chunxiu, et al. "Rosmarinic Acid Improved Antioxidant Properties and Healthspan Via the IIS and MAPK Pathways in Caenorhabditis Elegans." BioFactors (Oxford, England), vol. 45, no. 5, 2019, pp. 774-787.
Lin C, Xiao J, Xi Y, et al. Rosmarinic acid improved antioxidant properties and healthspan via the IIS and MAPK pathways in Caenorhabditis elegans. Biofactors. 2019;45(5):774-787.
Lin, C., Xiao, J., Xi, Y., Zhang, X., Zhong, Q., Zheng, H., Cao, Y., & Chen, Y. (2019). Rosmarinic acid improved antioxidant properties and healthspan via the IIS and MAPK pathways in Caenorhabditis elegans. BioFactors (Oxford, England), 45(5), 774-787. https://doi.org/10.1002/biof.1536
Lin C, et al. Rosmarinic Acid Improved Antioxidant Properties and Healthspan Via the IIS and MAPK Pathways in Caenorhabditis Elegans. Biofactors. 2019;45(5):774-787. PubMed PMID: 31206890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rosmarinic acid improved antioxidant properties and healthspan via the IIS and MAPK pathways in Caenorhabditis elegans. AU - Lin,Chunxiu, AU - Xiao,Jie, AU - Xi,Yun, AU - Zhang,Xiaoying, AU - Zhong,Qiqi, AU - Zheng,Huijuan, AU - Cao,Yong, AU - Chen,Yunjiao, Y1 - 2019/06/17/ PY - 2019/04/10/received PY - 2019/05/29/accepted PY - 2019/6/18/pubmed PY - 2019/6/18/medline PY - 2019/6/18/entrez KW - C. elegans KW - antiaging KW - antioxidant properties KW - longevity KW - rosmarinic acid SP - 774 EP - 787 JF - BioFactors (Oxford, England) JO - Biofactors VL - 45 IS - 5 N2 - Rosmarinic acid (RA) has a wide range of biological effects, including the antioxidation and antiaging. However, the detailed mechanisms remain unclear but highly attractive. Herein, RA promoted lifespan and motoricity in a dose-dependent manner, and reduced fat store without threatening fertility in Caenorhabditis elegans. In term of antioxidant efficacy, catalase activity, glutathione peroxidas activity, reduced glutathione content, and reduced glutathione/oxidized glutathione ratio were enhanced. And malondialdehyde content was diminished significantly. Moreover, RA increased survival under acute oxidative and thermal stress, and suppressed intestinal lipofuscin accumulation. So the improvement of lifespan mediated by RA could be related with its strong antioxidant properties. Furthermore, RA was absorbed by worms. Further research in pursuit of the mechanism showed that longevity induced by RA was involved with the genes sod-3, sod-5, ctl-1, daf-16, ins-18, skn-1, and sek-1, but was independent of subcellular localization of DAF-16. These findings indicated that RA had a potential for promoting healthy lifespan. SN - 1872-8081 UR - https://www.unboundmedicine.com/medline/citation/31206890/Rosmarinic_acid_improved_antioxidant_properties_and_healthspan_via_the_IIS_and_MAPK_pathways_in_Caenorhabditis_elegans_ L2 - https://doi.org/10.1002/biof.1536 DB - PRIME DP - Unbound Medicine ER -