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Atomic matching catalysis to realize a highly selective and sensitive biomimetic uric acid sensor.

Abstract

A main challenge for biomimetic non-enzyme biosensors is to achieve high selectivity. Herein, an innovative biomimetic non-enzyme sensor for electrochemical detection of uric acid (UA) with high selectivity and sensitivity is realized by growing Prussian blue (PB) nanoparticles on nitrogen-doped carbon nanotubes (N-doped CNTs). The enhancement mechanism of the biomimetic UA sensor is proposed to be atomically matched active sites between two reaction sites (oxygen atoms of 2, 8-trione, 6.9 Å) of UA molecule and two redox centers (FeII on the diagonal, 7.2 Å) of PB. Such an atomically matching manner not only promotes strong adsorption of UA on PB but also selectively enhances electron transfer between reaction sites of UA and active FeII centers of PB. This biomimetic UA sensor can offer great selectivity to avoid interferences from other oxidative and reductive species, showing excellent selectivity. An electrochemical biomimetic sensor based on PB/N-doped CNTs was applied to in situ detect UA in human serum, delivering a wide dynamic detection range (0.001-1 mM) and a low detection limit (0.26 μM). This work provides a high-performance UA sensor while shedding a scientific light on using atomic matching catalysis to fabricate highly sensitive and selective biomimetic sensors.

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  • Authors+Show Affiliations

    ,

    Institute of Materials Science and Devices, Suzhou University of Science and Technology, Suzhou, 215011, China.

    ,

    College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.

    ,

    Institute for Clean Energy and Advanced Materials, School of Materials and Energy, Southwest University, Chongqing, 400715, China.

    ,

    Institute of Materials Science and Devices, Suzhou University of Science and Technology, Suzhou, 215011, China.

    ,

    Institute for Clean Energy and Advanced Materials, School of Materials and Energy, Southwest University, Chongqing, 400715, China.

    ,

    Institute of Materials Science and Devices, Suzhou University of Science and Technology, Suzhou, 215011, China.

    Institute of Materials Science and Devices, Suzhou University of Science and Technology, Suzhou, 215011, China; Institute for Clean Energy and Advanced Materials, School of Materials and Energy, Southwest University, Chongqing, 400715, China; Institute of Advanced Cross-field Science, College of Life Science, Qingdao University, Qingdao, 266071, China. Electronic address: ecmli@swu.edu.cn.

    Source

    Biosensors & bioelectronics 141: 2019 Jun 07 pg 111421

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31207567

    Citation

    Shi, Zhuanzhuan, et al. "Atomic Matching Catalysis to Realize a Highly Selective and Sensitive Biomimetic Uric Acid Sensor." Biosensors & Bioelectronics, vol. 141, 2019, p. 111421.
    Shi Z, Li X, Yu L, et al. Atomic matching catalysis to realize a highly selective and sensitive biomimetic uric acid sensor. Biosens Bioelectron. 2019;141:111421.
    Shi, Z., Li, X., Yu, L., Wu, X., Wu, J., Guo, C., & Li, C. M. (2019). Atomic matching catalysis to realize a highly selective and sensitive biomimetic uric acid sensor. Biosensors & Bioelectronics, 141, p. 111421. doi:10.1016/j.bios.2019.111421.
    Shi Z, et al. Atomic Matching Catalysis to Realize a Highly Selective and Sensitive Biomimetic Uric Acid Sensor. Biosens Bioelectron. 2019 Jun 7;141:111421. PubMed PMID: 31207567.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Atomic matching catalysis to realize a highly selective and sensitive biomimetic uric acid sensor. AU - Shi,Zhuanzhuan, AU - Li,Xiaoli, AU - Yu,Ling, AU - Wu,Xiaoshuai, AU - Wu,Jinggao, AU - Guo,Chunxian, AU - Li,Chang Ming, Y1 - 2019/06/07/ PY - 2019/02/19/received PY - 2019/05/21/revised PY - 2019/06/06/accepted PY - 2019/6/18/pubmed PY - 2019/6/18/medline PY - 2019/6/18/entrez KW - Atomic matching catalysis KW - Biomimetic enzyme KW - Biosensor KW - High selectivity KW - Uric acid detection SP - 111421 EP - 111421 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 141 N2 - A main challenge for biomimetic non-enzyme biosensors is to achieve high selectivity. Herein, an innovative biomimetic non-enzyme sensor for electrochemical detection of uric acid (UA) with high selectivity and sensitivity is realized by growing Prussian blue (PB) nanoparticles on nitrogen-doped carbon nanotubes (N-doped CNTs). The enhancement mechanism of the biomimetic UA sensor is proposed to be atomically matched active sites between two reaction sites (oxygen atoms of 2, 8-trione, 6.9 Å) of UA molecule and two redox centers (FeII on the diagonal, 7.2 Å) of PB. Such an atomically matching manner not only promotes strong adsorption of UA on PB but also selectively enhances electron transfer between reaction sites of UA and active FeII centers of PB. This biomimetic UA sensor can offer great selectivity to avoid interferences from other oxidative and reductive species, showing excellent selectivity. An electrochemical biomimetic sensor based on PB/N-doped CNTs was applied to in situ detect UA in human serum, delivering a wide dynamic detection range (0.001-1 mM) and a low detection limit (0.26 μM). This work provides a high-performance UA sensor while shedding a scientific light on using atomic matching catalysis to fabricate highly sensitive and selective biomimetic sensors. SN - 1873-4235 UR - https://www.unboundmedicine.com/medline/citation/31207567/Atomic_matching_catalysis_to_realize_a_highly_selective_and_sensitive_biomimetic_uric_acid_sensor L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(19)30500-7 DB - PRIME DP - Unbound Medicine ER -