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The Association Between Osteocalcin and C-Reactive Protein; A Relation of Bone with Inflammation: A Systematic Review and Meta-Analysis.

Abstract

A meta-analysis was performed to summarize the evidence from observational studies regarding the association between serum osteocalcin (OC) and C-reactive protein (CRP). A systemic research of the literature databases including PubMed, SCOPUS, and Google Scholar was performed to identify the relevant studies up to March 2018. We used the random-effects model by the method of DerSimonian and Laird to calculate the overall effect size. Q-test and I 2-statistics were used to assess between-study heterogeneity. In addition, we did subgroup analysis to detect possible sources of heterogeneity based on BMI range, gender, type of study population and age. We identified 21studies of association between serum osteocalcin and CRP eligible for the meta-analysis. The overall effect size showed a significant inverse association between OC and CRP (Fisher's z=-0.127; 95% CI: -0.166, -0.088, p<0.0001). However, the significant chi-squared statistic result, indicates a heterogeneity of effect sizes (I 2=61.6, df=20, p<0.0001). The subgroup analysis found BMI range, type of study population, and age were the potential sources of heterogeneity. In addition, the strongest correlation was observed in the subgroup of obese subjects (Fisher's z=-0.264, p=0.002), less than 40 years old (Fisher's z=-0.115, p<0.0001) and healthy subjects (Fisher's z=-0.115, p<0.0001). These findings suggest that there is a significant inverse association between serum OC and CRP levels in the adult population.

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  • Authors+Show Affiliations

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    Student Research Committee, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

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    Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

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    Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.

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    Department of Human Nutrition, College of Health Sciences, Qatar University, Doha, Qatar.

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    Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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    Pharmacy Department Iran Drug and Poisons Information Center (DPIC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.

    Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31207656

    Citation

    Fatahi, Somaye, et al. "The Association Between Osteocalcin and C-Reactive Protein; a Relation of Bone With Inflammation: a Systematic Review and Meta-Analysis." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 51, no. 6, 2019, pp. 353-361.
    Fatahi S, Ghaedi E, Mousavi SM, et al. The Association Between Osteocalcin and C-Reactive Protein; A Relation of Bone with Inflammation: A Systematic Review and Meta-Analysis. Horm Metab Res. 2019;51(6):353-361.
    Fatahi, S., Ghaedi, E., Mousavi, S. M., Bawadi, H., Rahmani, J., Pezeshki, M., & Varkaneh, H. K. (2019). The Association Between Osteocalcin and C-Reactive Protein; A Relation of Bone with Inflammation: A Systematic Review and Meta-Analysis. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 51(6), pp. 353-361. doi:10.1055/a-0897-844.
    Fatahi S, et al. The Association Between Osteocalcin and C-Reactive Protein; a Relation of Bone With Inflammation: a Systematic Review and Meta-Analysis. Horm Metab Res. 2019;51(6):353-361. PubMed PMID: 31207656.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The Association Between Osteocalcin and C-Reactive Protein; A Relation of Bone with Inflammation: A Systematic Review and Meta-Analysis. AU - Fatahi,Somaye, AU - Ghaedi,Ehsan, AU - Mousavi,Seyed Mohammad, AU - Bawadi,Hiba, AU - Rahmani,Jamal, AU - Pezeshki,Mehran, AU - Varkaneh,Hamed Kord, Y1 - 2019/06/17/ PY - 2019/6/18/entrez PY - 2019/6/18/pubmed PY - 2019/6/18/medline SP - 353 EP - 361 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 51 IS - 6 N2 - A meta-analysis was performed to summarize the evidence from observational studies regarding the association between serum osteocalcin (OC) and C-reactive protein (CRP). A systemic research of the literature databases including PubMed, SCOPUS, and Google Scholar was performed to identify the relevant studies up to March 2018. We used the random-effects model by the method of DerSimonian and Laird to calculate the overall effect size. Q-test and I 2-statistics were used to assess between-study heterogeneity. In addition, we did subgroup analysis to detect possible sources of heterogeneity based on BMI range, gender, type of study population and age. We identified 21studies of association between serum osteocalcin and CRP eligible for the meta-analysis. The overall effect size showed a significant inverse association between OC and CRP (Fisher's z=-0.127; 95% CI: -0.166, -0.088, p<0.0001). However, the significant chi-squared statistic result, indicates a heterogeneity of effect sizes (I 2=61.6, df=20, p<0.0001). The subgroup analysis found BMI range, type of study population, and age were the potential sources of heterogeneity. In addition, the strongest correlation was observed in the subgroup of obese subjects (Fisher's z=-0.264, p=0.002), less than 40 years old (Fisher's z=-0.115, p<0.0001) and healthy subjects (Fisher's z=-0.115, p<0.0001). These findings suggest that there is a significant inverse association between serum OC and CRP levels in the adult population. SN - 1439-4286 UR - https://www.unboundmedicine.com/medline/citation/31207656/The_Association_Between_Osteocalcin_and_C-Reactive_Protein L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/a-0897-844 DB - PRIME DP - Unbound Medicine ER -