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Late presentation of HIV positive adults and its predictors to HIV/AIDS care in Ethiopia: a systematic review and meta-analysis.
BMC Infect Dis. 2019 Jun 17; 19(1):534.BI

Abstract

INTRODUCTION

Late presentation to HIV/AIDS care which is attended by problems like, poor treatment outcomes, early development of opportunistic infections, increased healthcare costs, and mortality is a major problem in Ethiopia. Although evidences are available on the prevalence and associated factors of late presentation to HIV/AIDS care, discrepancies among findings are appreciated. Thus, the country has faced difficulties of having a single estimated data.

OBJECTIVE

This study aimed to estimate the pooled prevalence of late presentation of HIV positive adults to HIV/AIDS care and its predictors in Ethiopia.

METHOD

We searched all available articles through Google Scholar, PubMed, Web of Sciences, and EMBASE databases. Additionally, we accessed articles from the Ethiopian institutional online research repositories and reference lists of included studies. We included cohort, case- control, and cross-sectional studies in our review. Besides, we utilized the weighted inverse variance random-effects model. The total percentage of variation among studies due to heterogeneity was determined by I2 statistic. Searching was limited to studies conducted in Ethiopia and published in the English language. Publication bias was checked by Egger's regression test.

RESULTS

A total of 8 studies with 7, 568 participants were included. The pooled prevalence of late presentation to HIV/AIDS care was 52.89% (95%CI: 35.37, 70.40). The odds of late presentation to HIV/AIDS care of frequent alcohol users [3.67(95% CI = 1.52-5.83)], high fear of stigma [3.90 (95% CI = 1.51-6.28)], chronic illness [3.34(95% CI = 1.52-5.16)], and the presence of symptoms at the time of HIV diagnosis [3.06 (95% CL = 1.18-4.94)] were higher compared to participants who did not experience the preceding.

CONCLUSION

The prevalence of late presentation of HIV positive adults to HIV/AIDS care was high in Ethiopia. Frequent alcohol use, high fear of stigma, chronic illness, and the presence of symptoms at the time of HIV diagnosis were associated with high odds of late presentation to HIV/AIDS care.

TRIAL REGISTRATION

Registered in PROSPERO databases with the registration number of CRD42018081840 .

Links

PMC Free PDF

Authors+Show Affiliations

Belay GM
Department of Pediatrics and Child Health Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, P.O. BOX: 196, Gondar, Ethiopia. getanehmulua@gmail.com.
Endalamaw A
Department of Pediatrics and Child Health Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, P.O. BOX: 196, Gondar, Ethiopia.
Ayele AD
Department of Pediatrics and Child Health Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, P.O. BOX: 196, Gondar, Ethiopia.

MeSH

EthiopiaHIV InfectionsHumansPrevalenceRisk FactorsTime-to-Treatment

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

31208360

Citation

Belay, Getaneh Mulualem, et al. "Late Presentation of HIV Positive Adults and Its Predictors to HIV/AIDS Care in Ethiopia: a Systematic Review and Meta-analysis." BMC Infectious Diseases, vol. 19, no. 1, 2019, p. 534.
Belay GM, Endalamaw A, Ayele AD. Late presentation of HIV positive adults and its predictors to HIV/AIDS care in Ethiopia: a systematic review and meta-analysis. BMC Infect Dis. 2019;19(1):534.
Belay, G. M., Endalamaw, A., & Ayele, A. D. (2019). Late presentation of HIV positive adults and its predictors to HIV/AIDS care in Ethiopia: a systematic review and meta-analysis. BMC Infectious Diseases, 19(1), 534. https://doi.org/10.1186/s12879-019-4156-3
Belay GM, Endalamaw A, Ayele AD. Late Presentation of HIV Positive Adults and Its Predictors to HIV/AIDS Care in Ethiopia: a Systematic Review and Meta-analysis. BMC Infect Dis. 2019 Jun 17;19(1):534. PubMed PMID: 31208360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Late presentation of HIV positive adults and its predictors to HIV/AIDS care in Ethiopia: a systematic review and meta-analysis. AU - Belay,Getaneh Mulualem, AU - Endalamaw,Aklilu, AU - Ayele,Amare Demsie, Y1 - 2019/06/17/ PY - 2019/02/19/received PY - 2019/05/31/accepted PY - 2019/6/19/entrez PY - 2019/6/19/pubmed PY - 2019/8/14/medline KW - Ethiopia KW - HIV/AIDS care KW - Late presentation KW - Meta-analysis SP - 534 EP - 534 JF - BMC infectious diseases JO - BMC Infect Dis VL - 19 IS - 1 N2 - INTRODUCTION: Late presentation to HIV/AIDS care which is attended by problems like, poor treatment outcomes, early development of opportunistic infections, increased healthcare costs, and mortality is a major problem in Ethiopia. Although evidences are available on the prevalence and associated factors of late presentation to HIV/AIDS care, discrepancies among findings are appreciated. Thus, the country has faced difficulties of having a single estimated data. OBJECTIVE: This study aimed to estimate the pooled prevalence of late presentation of HIV positive adults to HIV/AIDS care and its predictors in Ethiopia. METHOD: We searched all available articles through Google Scholar, PubMed, Web of Sciences, and EMBASE databases. Additionally, we accessed articles from the Ethiopian institutional online research repositories and reference lists of included studies. We included cohort, case- control, and cross-sectional studies in our review. Besides, we utilized the weighted inverse variance random-effects model. The total percentage of variation among studies due to heterogeneity was determined by I2 statistic. Searching was limited to studies conducted in Ethiopia and published in the English language. Publication bias was checked by Egger's regression test. RESULTS: A total of 8 studies with 7, 568 participants were included. The pooled prevalence of late presentation to HIV/AIDS care was 52.89% (95%CI: 35.37, 70.40). The odds of late presentation to HIV/AIDS care of frequent alcohol users [3.67(95% CI = 1.52-5.83)], high fear of stigma [3.90 (95% CI = 1.51-6.28)], chronic illness [3.34(95% CI = 1.52-5.16)], and the presence of symptoms at the time of HIV diagnosis [3.06 (95% CL = 1.18-4.94)] were higher compared to participants who did not experience the preceding. CONCLUSION: The prevalence of late presentation of HIV positive adults to HIV/AIDS care was high in Ethiopia. Frequent alcohol use, high fear of stigma, chronic illness, and the presence of symptoms at the time of HIV diagnosis were associated with high odds of late presentation to HIV/AIDS care. TRIAL REGISTRATION: Registered in PROSPERO databases with the registration number of CRD42018081840 . SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/31208360/Late_presentation_of_HIV_positive_adults_and_its_predictors_to_HIV/AIDS_care_in_Ethiopia:_a_systematic_review_and_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -