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Aerobic Exercise Performance and Muscle Strength in Statin Users-The LIFESTAT Study.
Med Sci Sports Exerc. 2019 07; 51(7):1429-1437.MS

Abstract

INTRODUCTION

Statins are widely used in both primary and secondary prevention of cardiovascular disease. The treatment increases the risk of muscle pain (myalgia) which can affect muscle function and levels of physical activity. We investigated whether statin-associated myalgia is coupled to impaired aerobic exercise performance including fat oxidation as well as impaired muscle strength.

METHODS

A population-based survey (6000 people) was performed to assess the prevalence of statin-associated myalgia in the Danish population. In addition, 64 statin users in primary prevention with myalgia (M; n = 25; 61 ± 1 yr) or without myalgia (NM; n = 37; 63 ± 1 yr) as well as a control group not taking statins (C; n = 20; 60 ± 2 yr) were enrolled in a cross-sectional study where they performed aerobic exercise and muscle strength tests.

RESULTS

The response rate for the survey was 51% and data showed a prevalence of statin-associated myalgia in 19% of responders using statins. The experimental study showed no difference between the groups in aerobic capacity (C, 29 ± 1 mL O2·min·kg; M, 27 ± 1 mL O2·min·kg; NM, 28 ± 1 mL O2·min·kg) or maximal fat oxidation (C, 247 ± 26 mg·min; M, 295 ± 24 mg·min; NM, 279 ± 17 mg·min). Measurements of strength were similar in all three groups including rate of force development (C, 795 ± 56 N·m·s; M, 930 ± 93 N·m·s; NM, 971 ± 57 N·m·s) and leg extension power (C: 2.6 ± 0.2; M: 2.3 ± 0.1; NM: 2.4 ± 0.1 W·kg). All results are mean ± SEM.

CONCLUSION

Statin users in primary prevention experiencing myalgia do not have impaired aerobic exercise performance or muscle strength compared to nonmyalgic statin users or control subjects.

Authors+Show Affiliations

Xlab, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, DENMARK. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DENMARK.Xlab, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, DENMARK.Xlab, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, DENMARK.Xlab, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, DENMARK.Department of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, DENMARK.Xlab, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, DENMARK. Clinical Research Centre, Medical University of Bialystok, Bialystok, POLAND.Xlab, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, DENMARK. Department of Geriatrics, Bispebjerg university hospital, Copenhagen, DENMARK.Xlab, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, DENMARK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31210648

Citation

Morville, Thomas, et al. "Aerobic Exercise Performance and Muscle Strength in Statin Users-The LIFESTAT Study." Medicine and Science in Sports and Exercise, vol. 51, no. 7, 2019, pp. 1429-1437.
Morville T, Dohlmann TL, Kuhlman AB, et al. Aerobic Exercise Performance and Muscle Strength in Statin Users-The LIFESTAT Study. Med Sci Sports Exerc. 2019;51(7):1429-1437.
Morville, T., Dohlmann, T. L., Kuhlman, A. B., Sahl, R. E., Kriegbaum, M., Larsen, S., Dela, F., & Helge, J. W. (2019). Aerobic Exercise Performance and Muscle Strength in Statin Users-The LIFESTAT Study. Medicine and Science in Sports and Exercise, 51(7), 1429-1437. https://doi.org/10.1249/MSS.0000000000001920
Morville T, et al. Aerobic Exercise Performance and Muscle Strength in Statin Users-The LIFESTAT Study. Med Sci Sports Exerc. 2019;51(7):1429-1437. PubMed PMID: 31210648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aerobic Exercise Performance and Muscle Strength in Statin Users-The LIFESTAT Study. AU - Morville,Thomas, AU - Dohlmann,Tine Lovsø, AU - Kuhlman,Anja Birk, AU - Sahl,Ronni Eg, AU - Kriegbaum,Margit, AU - Larsen,Steen, AU - Dela,Flemming, AU - Helge,Jørn Wulff, PY - 2019/6/19/entrez PY - 2019/6/19/pubmed PY - 2020/1/14/medline SP - 1429 EP - 1437 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 51 IS - 7 N2 - INTRODUCTION: Statins are widely used in both primary and secondary prevention of cardiovascular disease. The treatment increases the risk of muscle pain (myalgia) which can affect muscle function and levels of physical activity. We investigated whether statin-associated myalgia is coupled to impaired aerobic exercise performance including fat oxidation as well as impaired muscle strength. METHODS: A population-based survey (6000 people) was performed to assess the prevalence of statin-associated myalgia in the Danish population. In addition, 64 statin users in primary prevention with myalgia (M; n = 25; 61 ± 1 yr) or without myalgia (NM; n = 37; 63 ± 1 yr) as well as a control group not taking statins (C; n = 20; 60 ± 2 yr) were enrolled in a cross-sectional study where they performed aerobic exercise and muscle strength tests. RESULTS: The response rate for the survey was 51% and data showed a prevalence of statin-associated myalgia in 19% of responders using statins. The experimental study showed no difference between the groups in aerobic capacity (C, 29 ± 1 mL O2·min·kg; M, 27 ± 1 mL O2·min·kg; NM, 28 ± 1 mL O2·min·kg) or maximal fat oxidation (C, 247 ± 26 mg·min; M, 295 ± 24 mg·min; NM, 279 ± 17 mg·min). Measurements of strength were similar in all three groups including rate of force development (C, 795 ± 56 N·m·s; M, 930 ± 93 N·m·s; NM, 971 ± 57 N·m·s) and leg extension power (C: 2.6 ± 0.2; M: 2.3 ± 0.1; NM: 2.4 ± 0.1 W·kg). All results are mean ± SEM. CONCLUSION: Statin users in primary prevention experiencing myalgia do not have impaired aerobic exercise performance or muscle strength compared to nonmyalgic statin users or control subjects. SN - 1530-0315 UR - https://www.unboundmedicine.com/medline/citation/31210648/Aerobic_Exercise_Performance_and_Muscle_Strength_in_Statin_Users_The_LIFESTAT_Study_ L2 - http://dx.doi.org/10.1249/MSS.0000000000001920 DB - PRIME DP - Unbound Medicine ER -