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Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities.

Abstract

Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities. Currently, several classes of natural molecules from spider venoms are potential sources of chemotherapeutics against tumor cells. Some of the spider peptide toxins produce lethal effects on tumor cells by regulating the cell cycle, activating caspase pathway or inactivating mitochondria. Some of them also target the various types of ion channels (including voltage-gated calcium channels, voltage-gated sodium channels, and acid-sensing ion channels) among other pain-related targets. Herein we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against the pathophysiological conditions including cancer and pain.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha, Hunan 410013, China. Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha, Hunan 410013, China. Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha, Hunan 410013, China.Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha, Hunan 410013, China.Department of Parasitology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.Department of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha, Hunan 410013, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31210759

Citation

Wu, Ting, et al. "Spider Venom Peptides as Potential Drug Candidates Due to Their Anticancer and Antinociceptive Activities." The Journal of Venomous Animals and Toxins Including Tropical Diseases, vol. 25, 2019, pp. e146318.
Wu T, Wang M, Wu W, et al. Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities. The journal of venomous animals and toxins including tropical diseases. 2019;25:e146318.
Wu, T., Wang, M., Wu, W., Luo, Q., Jiang, L., Tao, H., & Deng, M. (2019). Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities. The Journal of Venomous Animals and Toxins Including Tropical Diseases, 25, e146318. https://doi.org/10.1590/1678-9199-JVATITD-14-63-18
Wu T, et al. Spider Venom Peptides as Potential Drug Candidates Due to Their Anticancer and Antinociceptive Activities. The journal of venomous animals and toxins including tropical diseases. 2019;25:e146318. PubMed PMID: 31210759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities. AU - Wu,Ting, AU - Wang,Meng, AU - Wu,Wenfang, AU - Luo,Qianxuan, AU - Jiang,Liping, AU - Tao,Huai, AU - Deng,Meichun, Y1 - 2019/06/03/ PY - 2018/06/13/received PY - 2018/11/15/accepted PY - 2019/6/19/entrez PY - 2019/6/19/pubmed PY - 2019/6/19/medline KW - antitumor KW - drug candidates KW - pain KW - spider venom peptides SP - e146318 EP - e146318 JF - The journal of venomous animals and toxins including tropical diseases VL - 25 N2 - Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities. Currently, several classes of natural molecules from spider venoms are potential sources of chemotherapeutics against tumor cells. Some of the spider peptide toxins produce lethal effects on tumor cells by regulating the cell cycle, activating caspase pathway or inactivating mitochondria. Some of them also target the various types of ion channels (including voltage-gated calcium channels, voltage-gated sodium channels, and acid-sensing ion channels) among other pain-related targets. Herein we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against the pathophysiological conditions including cancer and pain. SN - 1678-9199 UR - https://www.unboundmedicine.com/medline/citation/31210759/Spider_venom_peptides_as_potential_drug_candidates_due_to_their_anticancer_and_antinociceptive_activities_ L2 - https://jvat.biomedcentral.com/articles/10.1590/1678-9199-JVATITD-14-63-18 DB - PRIME DP - Unbound Medicine ER -
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