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Orally disintegrating tablets and orally disintegrating mini tablets - novel dosage forms for pediatric use.
Pharm Dev Technol. 2019 Sep; 24(7):902-914.PD

Abstract

The oral administration route is considered to be the most widely used route because of its convenience of administration and manufacturing. Dosage forms, like orally disintegrating tablets (ODTs), mini tablets, and orally disintegrating mini tablets (ODMTs), are recognized as promising for use in pediatric patients. ODTs are known to be suitable drug delivery systems, especially for pediatric patients, because of their rapid disintegration properties, use without water, and no swallowing problems. In addition, in recent years, a new formulation approach has been developed. ODMTs, are the newest drug delivery systems. They combine the advantageous properties of ODTs and the small size of mini tablets, aimed for pediatric use. These tablets, which can be formulated as 2-4 mm in diameter, are known as drug delivery systems that have children acceptability age as low as 6-months old. The fact that the ODTs and the ODMTs can be formulated with acceptable flavors for children further increases the importance of these carrier systems in the treatment. The objective of this article is to highlight the development of ODTs and mini-ODTs, their significance, ideal characteristics, various techniques, and aspects related to design and formulation, marketed preparations, and future perspectives, especially for the pediatric patients.

Authors+Show Affiliations

a Department of Pharmaceutical Technology, Faculty of Pharmacy , Ankara University , Ankara , Turkey.a Department of Pharmaceutical Technology, Faculty of Pharmacy , Ankara University , Ankara , Turkey. b Department of Pharmaceutical Technology, Faculty of Pharmacy, Eastern Mediterranean University , Famagusta, Turkey.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31215850

Citation

Comoglu, Tansel, and Emine Dilek Ozyilmaz. "Orally Disintegrating Tablets and Orally Disintegrating Mini Tablets - Novel Dosage Forms for Pediatric Use." Pharmaceutical Development and Technology, vol. 24, no. 7, 2019, pp. 902-914.
Comoglu T, Dilek Ozyilmaz E. Orally disintegrating tablets and orally disintegrating mini tablets - novel dosage forms for pediatric use. Pharm Dev Technol. 2019;24(7):902-914.
Comoglu, T., & Dilek Ozyilmaz, E. (2019). Orally disintegrating tablets and orally disintegrating mini tablets - novel dosage forms for pediatric use. Pharmaceutical Development and Technology, 24(7), 902-914. https://doi.org/10.1080/10837450.2019.1615090
Comoglu T, Dilek Ozyilmaz E. Orally Disintegrating Tablets and Orally Disintegrating Mini Tablets - Novel Dosage Forms for Pediatric Use. Pharm Dev Technol. 2019;24(7):902-914. PubMed PMID: 31215850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Orally disintegrating tablets and orally disintegrating mini tablets - novel dosage forms for pediatric use. AU - Comoglu,Tansel, AU - Dilek Ozyilmaz,Emine, PY - 2019/6/20/entrez PY - 2019/6/20/pubmed PY - 2019/12/4/medline KW - Pediatric formulations KW - advantages KW - limitations KW - orally disintegrating tablets KW - preparation method KW - quality controls of orally disintegrating mini tablets SP - 902 EP - 914 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 24 IS - 7 N2 - The oral administration route is considered to be the most widely used route because of its convenience of administration and manufacturing. Dosage forms, like orally disintegrating tablets (ODTs), mini tablets, and orally disintegrating mini tablets (ODMTs), are recognized as promising for use in pediatric patients. ODTs are known to be suitable drug delivery systems, especially for pediatric patients, because of their rapid disintegration properties, use without water, and no swallowing problems. In addition, in recent years, a new formulation approach has been developed. ODMTs, are the newest drug delivery systems. They combine the advantageous properties of ODTs and the small size of mini tablets, aimed for pediatric use. These tablets, which can be formulated as 2-4 mm in diameter, are known as drug delivery systems that have children acceptability age as low as 6-months old. The fact that the ODTs and the ODMTs can be formulated with acceptable flavors for children further increases the importance of these carrier systems in the treatment. The objective of this article is to highlight the development of ODTs and mini-ODTs, their significance, ideal characteristics, various techniques, and aspects related to design and formulation, marketed preparations, and future perspectives, especially for the pediatric patients. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/31215850/Orally_disintegrating_tablets_and_orally_disintegrating_mini_tablets___novel_dosage_forms_for_pediatric_use_ L2 - http://www.tandfonline.com/doi/full/10.1080/10837450.2019.1615090 DB - PRIME DP - Unbound Medicine ER -