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Clinical relevance of skeletal muscle abnormalities in patients with cirrhosis.
Dig Liver Dis. 2019 11; 51(11):1493-1499.DL

Abstract

Recent advances in body composition evaluation have demonstrated abnormalities in skeletal muscle in patients with cirrhosis. Sarcopenia (severe muscle depletion) and myosteatosis (pathological fat accumulation in muscle) are prevalent muscle abnormalities in patients with cirrhosis that confer poor prognosis. Sarcopenia has become a well-defined factor for adverse clinical outcomes pre- and post-liver transplantation and emerging evidence has suggested the prognostic significance of myosteatosis in predicting mortality and overt hepatic encephalopathy in patients with cirrhosis. Advances in the understating of these muscle abnormalities might help improve therapeutic interventions to correct them and potentially improve outcomes of patients with cirrhosis. Moreover, inclusion of these muscle abnormalities within the current organ allocation policies might lead to a better mortality risk assessment in patients awaiting liver transplant and even to a decrease in the rates of futile liver transplants. This review summarizes the current knowledge regarding the modalities to evaluate skeletal muscle abnormalities in cirrhosis, the incidence and clinical impact of these abnormalities in cirrhosis; existing and potential novel therapeutic strategies are also discussed.

Authors+Show Affiliations

Division of Gastroenterology & Liver Unit, University of Alberta Hospital, Edmonton, Alberta, Canada. Electronic address: ebadi@ualberta.ca.Division of Gastroenterology & Liver Unit, University of Alberta Hospital, Edmonton, Alberta, Canada. Electronic address: montanol@ualberta.ca.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31221549

Citation

Ebadi, Maryam, and Aldo J. Montano-Loza. "Clinical Relevance of Skeletal Muscle Abnormalities in Patients With Cirrhosis." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 51, no. 11, 2019, pp. 1493-1499.
Ebadi M, Montano-Loza AJ. Clinical relevance of skeletal muscle abnormalities in patients with cirrhosis. Dig Liver Dis. 2019;51(11):1493-1499.
Ebadi, M., & Montano-Loza, A. J. (2019). Clinical relevance of skeletal muscle abnormalities in patients with cirrhosis. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 51(11), 1493-1499. https://doi.org/10.1016/j.dld.2019.05.034
Ebadi M, Montano-Loza AJ. Clinical Relevance of Skeletal Muscle Abnormalities in Patients With Cirrhosis. Dig Liver Dis. 2019;51(11):1493-1499. PubMed PMID: 31221549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical relevance of skeletal muscle abnormalities in patients with cirrhosis. AU - Ebadi,Maryam, AU - Montano-Loza,Aldo J, Y1 - 2019/06/17/ PY - 2019/04/15/received PY - 2019/05/28/accepted PY - 2019/6/22/pubmed PY - 2019/6/22/medline PY - 2019/6/22/entrez KW - Chronic liver disease KW - Liver transplantation KW - Myosteatosis KW - Sarcopenia SP - 1493 EP - 1499 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 51 IS - 11 N2 - Recent advances in body composition evaluation have demonstrated abnormalities in skeletal muscle in patients with cirrhosis. Sarcopenia (severe muscle depletion) and myosteatosis (pathological fat accumulation in muscle) are prevalent muscle abnormalities in patients with cirrhosis that confer poor prognosis. Sarcopenia has become a well-defined factor for adverse clinical outcomes pre- and post-liver transplantation and emerging evidence has suggested the prognostic significance of myosteatosis in predicting mortality and overt hepatic encephalopathy in patients with cirrhosis. Advances in the understating of these muscle abnormalities might help improve therapeutic interventions to correct them and potentially improve outcomes of patients with cirrhosis. Moreover, inclusion of these muscle abnormalities within the current organ allocation policies might lead to a better mortality risk assessment in patients awaiting liver transplant and even to a decrease in the rates of futile liver transplants. This review summarizes the current knowledge regarding the modalities to evaluate skeletal muscle abnormalities in cirrhosis, the incidence and clinical impact of these abnormalities in cirrhosis; existing and potential novel therapeutic strategies are also discussed. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/31221549/Clinical_relevance_of_skeletal_muscle_abnormalities_in_patients_with_cirrhosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(19)30635-8 DB - PRIME DP - Unbound Medicine ER -
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