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Neonatal social isolation increases the proportion of the immature spines in the layer 2/3 pyramidal neurons of the somatosensory cortex.

Abstract

Social isolation during the juvenile period is postulated to leave specific sequelae, such as attention deficits and emotion recognition. Miswiring of the cortical neuronal circuit during postnatal development may underlie such behavioral impairments, but the details of the circuit-level impairment associated with social isolation have not yet been clarified. In this study, we evaluated the possibility that environmental factors may induce alternation in spine characteristics and dynamics. We isolated mice from the mother and siblings from postnatal day 7 to 11 for 6 h per day. Both dynamics and structural properties of spines in the layer 2/3 pyramidal neurons of the somatosensory cortex were measured at postnatal 3 weeks by in vivo two-photon microscopy. We found decrease in the ratio of PSD-95-positive dendritic spines in the mice after social isolation. These mice did not show alteration in spine dynamics. Those results suggest that the neonatal social isolation results in less mature spines, with normal rate of their turnover, which is distinct from spine phenotype seen in multiple models of autism spectrum disorders.

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  • Authors+Show Affiliations

    ,

    Department of Cellular Neurobiology Graduate School of Medicine, University of Tokyo, Tokyo, 113-0033 Japan.

    ,

    Department of Cellular Neurobiology Graduate School of Medicine, University of Tokyo, Tokyo, 113-0033 Japan.

    Department of Cellular Neurobiology Graduate School of Medicine, University of Tokyo, Tokyo, 113-0033 Japan. Electronic address: okabe@m.u-tokyo.ac.jp.

    Source

    Neuroscience research : 2019 Jun 18 pg

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31226269

    Citation

    Iguchi, Risa, et al. "Neonatal Social Isolation Increases the Proportion of the Immature Spines in the Layer 2/3 Pyramidal Neurons of the Somatosensory Cortex." Neuroscience Research, 2019.
    Iguchi R, Tanaka S, Okabe S. Neonatal social isolation increases the proportion of the immature spines in the layer 2/3 pyramidal neurons of the somatosensory cortex. Neurosci Res. 2019.
    Iguchi, R., Tanaka, S., & Okabe, S. (2019). Neonatal social isolation increases the proportion of the immature spines in the layer 2/3 pyramidal neurons of the somatosensory cortex. Neuroscience Research, doi:10.1016/j.neures.2019.05.004.
    Iguchi R, Tanaka S, Okabe S. Neonatal Social Isolation Increases the Proportion of the Immature Spines in the Layer 2/3 Pyramidal Neurons of the Somatosensory Cortex. Neurosci Res. 2019 Jun 18; PubMed PMID: 31226269.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Neonatal social isolation increases the proportion of the immature spines in the layer 2/3 pyramidal neurons of the somatosensory cortex. AU - Iguchi,Risa, AU - Tanaka,Shinji, AU - Okabe,Shigeo, Y1 - 2019/06/18/ PY - 2019/01/20/received PY - 2019/05/17/revised PY - 2019/05/20/accepted PY - 2019/6/22/pubmed PY - 2019/6/22/medline PY - 2019/6/22/entrez KW - Autism spectrum disorders KW - In vivo KW - PSD-95 KW - Social isolation KW - Somatosensory cortex KW - Spine turnover rate JF - Neuroscience research JO - Neurosci. Res. N2 - Social isolation during the juvenile period is postulated to leave specific sequelae, such as attention deficits and emotion recognition. Miswiring of the cortical neuronal circuit during postnatal development may underlie such behavioral impairments, but the details of the circuit-level impairment associated with social isolation have not yet been clarified. In this study, we evaluated the possibility that environmental factors may induce alternation in spine characteristics and dynamics. We isolated mice from the mother and siblings from postnatal day 7 to 11 for 6 h per day. Both dynamics and structural properties of spines in the layer 2/3 pyramidal neurons of the somatosensory cortex were measured at postnatal 3 weeks by in vivo two-photon microscopy. We found decrease in the ratio of PSD-95-positive dendritic spines in the mice after social isolation. These mice did not show alteration in spine dynamics. Those results suggest that the neonatal social isolation results in less mature spines, with normal rate of their turnover, which is distinct from spine phenotype seen in multiple models of autism spectrum disorders. SN - 1872-8111 UR - https://www.unboundmedicine.com/medline/citation/31226269/Neonatal_social_isolation_increases_the_proportion_of_the_immature_spines_in_the_layer_2/3_pyramidal_neurons_of_the_somatosensory_cortex L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-0102(19)30046-X DB - PRIME DP - Unbound Medicine ER -