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Optic neuritis, encephalitis and leptomeningeal enhancement in a patient with anti-MOG antibodies: A case study.
Mult Scler Relat Disord. 2019 Sep; 34:14-16.MS

Abstract

A subset of patients with neuromyelitis optica spectrum disorders are positive for myelin-oligodendrocyte glycoprotein (MOG) antibodies. These patients present with distinct clinical demyelinating syndrome often confused for multiple sclerosis. We describe the case of a patient who initially presented with 10-day history of right-sided retro-orbital headache worse with lateral gaze, photophobia, and subjective decreased visual acuity. After successful treatment on a steroid regimen, this patient represented two weeks following discharge with seizure and was found to have unilateral meningeal T2-FLAIR MRI hyperintensity with associated cortical swelling, a rare finding. CSF studies showed negative anti-AQP4 antibodies and positive anti-MOG antibodies. This case demonstrates that patients presenting with symptoms concerning for NMOSD who are AQP4-Ab-negative should be tested for anti-MOG antibodies for optimized disease management and important prognostic implications.

Authors+Show Affiliations

Warren Alpert Medical School of Brown University, 195 Waterman St. Apt 3, Providence, RI 02906, USA. Electronic address: Nichola_Haddad@brown.edu.Warren Alpert Medical School of Brown University, Department of Medicine, Providence, RI, USA. Electronic address: Breton_Roussel@brown.edu.Warren Alpert Medical School of Brown University, Department of Medicine, Providence, RI, USA. Electronic address: Ari.Pelcovits@lifespan.org.Warren Alpert Medical School of Brown University, Department of Neurology, Providence, RI, USA. Electronic address: SRizvi@lifespan.org.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

31226544

Citation

Haddad, Nichola, et al. "Optic Neuritis, Encephalitis and Leptomeningeal Enhancement in a Patient With anti-MOG Antibodies: a Case Study." Multiple Sclerosis and Related Disorders, vol. 34, 2019, pp. 14-16.
Haddad N, Roussel B, Pelcovits A, et al. Optic neuritis, encephalitis and leptomeningeal enhancement in a patient with anti-MOG antibodies: A case study. Mult Scler Relat Disord. 2019;34:14-16.
Haddad, N., Roussel, B., Pelcovits, A., & Rizvi, S. (2019). Optic neuritis, encephalitis and leptomeningeal enhancement in a patient with anti-MOG antibodies: A case study. Multiple Sclerosis and Related Disorders, 34, 14-16. https://doi.org/10.1016/j.msard.2019.06.010
Haddad N, et al. Optic Neuritis, Encephalitis and Leptomeningeal Enhancement in a Patient With anti-MOG Antibodies: a Case Study. Mult Scler Relat Disord. 2019;34:14-16. PubMed PMID: 31226544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optic neuritis, encephalitis and leptomeningeal enhancement in a patient with anti-MOG antibodies: A case study. AU - Haddad,Nichola, AU - Roussel,Breton, AU - Pelcovits,Ari, AU - Rizvi,Syed, Y1 - 2019/06/14/ PY - 2019/06/05/received PY - 2019/06/12/revised PY - 2019/06/13/accepted PY - 2019/6/22/pubmed PY - 2020/2/23/medline PY - 2019/6/22/entrez KW - Aquaporin-4 KW - Myelin-oligodendrocyte glycoprotein KW - Neuromyelitis optica KW - Neuromyelitis optica spectrum disorders KW - Optic neuritis SP - 14 EP - 16 JF - Multiple sclerosis and related disorders JO - Mult Scler Relat Disord VL - 34 N2 - A subset of patients with neuromyelitis optica spectrum disorders are positive for myelin-oligodendrocyte glycoprotein (MOG) antibodies. These patients present with distinct clinical demyelinating syndrome often confused for multiple sclerosis. We describe the case of a patient who initially presented with 10-day history of right-sided retro-orbital headache worse with lateral gaze, photophobia, and subjective decreased visual acuity. After successful treatment on a steroid regimen, this patient represented two weeks following discharge with seizure and was found to have unilateral meningeal T2-FLAIR MRI hyperintensity with associated cortical swelling, a rare finding. CSF studies showed negative anti-AQP4 antibodies and positive anti-MOG antibodies. This case demonstrates that patients presenting with symptoms concerning for NMOSD who are AQP4-Ab-negative should be tested for anti-MOG antibodies for optimized disease management and important prognostic implications. SN - 2211-0356 UR - https://www.unboundmedicine.com/medline/citation/31226544/Optic_neuritis_encephalitis_and_leptomeningeal_enhancement_in_a_patient_with_anti_MOG_antibodies:_A_case_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(19)30253-6 DB - PRIME DP - Unbound Medicine ER -