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Hydroxypropyl-β-cyclodextrin-based fast dissolving carbamazepine printlets prepared by semisolid extrusion 3D printing.
Carbohydr Polym. 2019 Oct 01; 221:55-62.CP

Abstract

This work aimed to explore for the first time the use of cyclodextrins to prepare printlets of poorly soluble drugs, such as carbamazepine, which require fine dose adjustment and rapid release. Orodispersible (flash) and immediate release formulations were 3D printed via semisolid extrusion of wet masses of hydroxypropyl-β-cyclodextrin (HPβCD) and cellulose ethers and regulating tablet porosity. Rheology of the wet masses allowed identifying printable compositions. Printing robustness was assessed evaluating weight, dimensions, hardness, drug content, and microstructure. Drug crystallinity, printlet disintegration and dissolution profiles were also characterized. The results highlight the feasibility of using HPβCD as excipient in printlets of poorly soluble drugs, and the possibilities of tuning drug release profiles through small changes in cellulose ethers nature and ratio. Semisolid extrusion-based 3D printing is revealed as a feasible approach to in situ form carbamazepine-HPβCD complexes and to produce printlets with suitable physical and drug release properties for oral delivery.

Authors+Show Affiliations

UCIBIO - REQUIMTE, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, R+D Pharma Group (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, R+D Pharma Group (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain; FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, United Kingdom.Research Institute for Medicines (iMed.ULisboa), Department of Galenic Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, R+D Pharma Group (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.Research Institute for Medicines (iMed.ULisboa), Department of Galenic Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.UCIBIO - REQUIMTE, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, R+D Pharma Group (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. Electronic address: carmen.alvarez.lorenzo@usc.es.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31227167

Citation

Conceição, Jaime, et al. "Hydroxypropyl-β-cyclodextrin-based Fast Dissolving Carbamazepine Printlets Prepared By Semisolid Extrusion 3D Printing." Carbohydrate Polymers, vol. 221, 2019, pp. 55-62.
Conceição J, Farto-Vaamonde X, Goyanes A, et al. Hydroxypropyl-β-cyclodextrin-based fast dissolving carbamazepine printlets prepared by semisolid extrusion 3D printing. Carbohydr Polym. 2019;221:55-62.
Conceição, J., Farto-Vaamonde, X., Goyanes, A., Adeoye, O., Concheiro, A., Cabral-Marques, H., Sousa Lobo, J. M., & Alvarez-Lorenzo, C. (2019). Hydroxypropyl-β-cyclodextrin-based fast dissolving carbamazepine printlets prepared by semisolid extrusion 3D printing. Carbohydrate Polymers, 221, 55-62. https://doi.org/10.1016/j.carbpol.2019.05.084
Conceição J, et al. Hydroxypropyl-β-cyclodextrin-based Fast Dissolving Carbamazepine Printlets Prepared By Semisolid Extrusion 3D Printing. Carbohydr Polym. 2019 Oct 1;221:55-62. PubMed PMID: 31227167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydroxypropyl-β-cyclodextrin-based fast dissolving carbamazepine printlets prepared by semisolid extrusion 3D printing. AU - Conceição,Jaime, AU - Farto-Vaamonde,Xián, AU - Goyanes,Alvaro, AU - Adeoye,Oluwatomide, AU - Concheiro,Angel, AU - Cabral-Marques,Helena, AU - Sousa Lobo,José Manuel, AU - Alvarez-Lorenzo,Carmen, Y1 - 2019/05/29/ PY - 2019/03/15/received PY - 2019/05/15/revised PY - 2019/05/15/accepted PY - 2019/6/23/entrez PY - 2019/6/23/pubmed PY - 2019/12/4/medline KW - 3D printed tablets KW - Additive manufacturing KW - Carbamazepine KW - Flash formulation KW - Hydroxypropyl-β-cyclodextrin KW - Semisolid extrusion SP - 55 EP - 62 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 221 N2 - This work aimed to explore for the first time the use of cyclodextrins to prepare printlets of poorly soluble drugs, such as carbamazepine, which require fine dose adjustment and rapid release. Orodispersible (flash) and immediate release formulations were 3D printed via semisolid extrusion of wet masses of hydroxypropyl-β-cyclodextrin (HPβCD) and cellulose ethers and regulating tablet porosity. Rheology of the wet masses allowed identifying printable compositions. Printing robustness was assessed evaluating weight, dimensions, hardness, drug content, and microstructure. Drug crystallinity, printlet disintegration and dissolution profiles were also characterized. The results highlight the feasibility of using HPβCD as excipient in printlets of poorly soluble drugs, and the possibilities of tuning drug release profiles through small changes in cellulose ethers nature and ratio. Semisolid extrusion-based 3D printing is revealed as a feasible approach to in situ form carbamazepine-HPβCD complexes and to produce printlets with suitable physical and drug release properties for oral delivery. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/31227167/Hydroxypropyl_β_cyclodextrin_based_fast_dissolving_carbamazepine_printlets_prepared_by_semisolid_extrusion_3D_printing_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0144-8617(19)30557-0 DB - PRIME DP - Unbound Medicine ER -