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Late effects of chemo and radiation treatment on dental structures of childhood cancer survivors. A systematic review and meta-analysis.
Head Neck. 2019 09; 41(9):3422-3433.HN

Abstract

BACKGROUND

This systematic review summarizes the prevalence of dental defects after chemo and radiation therapy and correlates the findings with specific characteristics of each treatment modality.

METHODS

Database search was performed for studies reporting dental late effects of chemo and radiation therapy. After data extraction and risk of bias assessment, prevalence of crown and root defects was assessed. Correlations between each defect and the characteristics of the antineoplastic treatment were performed.

RESULTS

Sixteen nonrandomized studies were included, yielding a total of 1300 patients with a mean age at diagnosis of 4.5 years. Results reported that root defects were more common than crown defects. The most common root defect was impaired root growth and microdontia the most common crown defect. Age, radiation dose and field were statistically associated with higher prevalence of dental defects.

CONCLUSION

Defects were associated with combination of chemotherapy and radiotherapy, as used in current therapeutic antineoplastic modalities.

Authors+Show Affiliations

Department of Paediatric Dentistry, Athens School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.Department of Orthodontics, 251 Greek Air Force Hospital, Athens, Greece. Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland.Department of Preventive and Community Dentistry, Athens School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.Division of Paediatric Haematology-Oncology, First Department of Paediatrics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.Department of Comprehensive Dentistry, Division of Pediatric Dentistry, University of Louisville, Louisville, Kentucky.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31228308

Citation

Seremidi, Kyriaki, et al. "Late Effects of Chemo and Radiation Treatment On Dental Structures of Childhood Cancer Survivors. a Systematic Review and Meta-analysis." Head & Neck, vol. 41, no. 9, 2019, pp. 3422-3433.
Seremidi K, Kloukos D, Polychronopoulou A, et al. Late effects of chemo and radiation treatment on dental structures of childhood cancer survivors. A systematic review and meta-analysis. Head Neck. 2019;41(9):3422-3433.
Seremidi, K., Kloukos, D., Polychronopoulou, A., Kattamis, A., & Kavvadia, K. (2019). Late effects of chemo and radiation treatment on dental structures of childhood cancer survivors. A systematic review and meta-analysis. Head & Neck, 41(9), 3422-3433. https://doi.org/10.1002/hed.25840
Seremidi K, et al. Late Effects of Chemo and Radiation Treatment On Dental Structures of Childhood Cancer Survivors. a Systematic Review and Meta-analysis. Head Neck. 2019;41(9):3422-3433. PubMed PMID: 31228308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Late effects of chemo and radiation treatment on dental structures of childhood cancer survivors. A systematic review and meta-analysis. AU - Seremidi,Kyriaki, AU - Kloukos,Dimitrios, AU - Polychronopoulou,Argy, AU - Kattamis,Antonis, AU - Kavvadia,Katerina, Y1 - 2019/06/22/ PY - 2019/03/14/received PY - 2019/05/17/revised PY - 2019/06/04/accepted PY - 2019/6/23/pubmed PY - 2019/6/23/medline PY - 2019/6/23/entrez KW - antineoplastic therapy KW - childhood cancer survivors KW - combined chemo and radiation therapy KW - dental defects KW - late effects SP - 3422 EP - 3433 JF - Head & neck JO - Head Neck VL - 41 IS - 9 N2 - BACKGROUND: This systematic review summarizes the prevalence of dental defects after chemo and radiation therapy and correlates the findings with specific characteristics of each treatment modality. METHODS: Database search was performed for studies reporting dental late effects of chemo and radiation therapy. After data extraction and risk of bias assessment, prevalence of crown and root defects was assessed. Correlations between each defect and the characteristics of the antineoplastic treatment were performed. RESULTS: Sixteen nonrandomized studies were included, yielding a total of 1300 patients with a mean age at diagnosis of 4.5 years. Results reported that root defects were more common than crown defects. The most common root defect was impaired root growth and microdontia the most common crown defect. Age, radiation dose and field were statistically associated with higher prevalence of dental defects. CONCLUSION: Defects were associated with combination of chemotherapy and radiotherapy, as used in current therapeutic antineoplastic modalities. SN - 1097-0347 UR - https://www.unboundmedicine.com/medline/citation/31228308/Late_effects_of_chemo_and_radiation_treatment_on_dental_structures_of_childhood_cancer_survivors._A_systematic_review_and_meta-analysis L2 - https://doi.org/10.1002/hed.25840 DB - PRIME DP - Unbound Medicine ER -
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