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Intussusceptive Lymphangiogenesis in Lymphatic Malformations/Lymphangiomas.
Anat Rec (Hoboken) 2019; 302(11):2003-2013AR

Abstract

Intussusception in lymphatic vessels has received less attention than in blood vessels. In tumors and pseudotumors of blood vessels with intravascular papillary structures, including sinusoidal hemangioma and intravascular papillary endothelial hyperplasia, we observed exuberant intussusceptive angiogenesis, as well as the similarity between papillae (term used by pathologists) and pillars/folds (hallmarks of intussusceptive angiogenesis). A similar response could be expected in lymphangiomas (lymphatic malformations and reactive processes rather than tumors) with papillae. The aim of this work is to assess whether papillae/pillars/folds and associated structures (vessel loops and septa) are present in lymphangiomas, and to establish the characteristics and formation of these structures. For this purpose, we selected lymphangiomas with intraluminal papillae (n = 18), including cystic, cavernous, circumscriptum, and progressive types, of which two cases of each type with a greater number of papillae were used for serial histologic sections and immunohistochemistry. The studies showed a) dilated lymphatic spaces giving rise to lymphatic-lymphatic vascular loops, which dissected and encircled perilymphatic structures (interstitial tissue structures/ITSs and pillars/posts), b) ITSs and pillars, surrounded by anti-podoplanin-positive endothelial cells, protruding into the lymphatic spaces (papillary aspect), and c) splitting, remodeling, linear arrangement, and fusion of papillae/pillars/folds, forming papillary networks and septa. In conclusion, as occurs in blood vessel diseases, the development of lymphatic vessel loops, papillae/pillars/folds, and septa (segmentation) supports intussusceptive lymphangiogenesis and suggests a piecemeal form of intussusception. This intussusceptive lymphangiogenesis in lymphatic diseases can provide a basis for further studies of lymphatic intussusception in other conditions, with clinical and therapeutic implications. Anat Rec, 302:2003-2013, 2019. © 2019 American Association for Anatomy.

Authors+Show Affiliations

Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, Tenerife, Spain.Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, Tenerife, Spain.Department of Pathology, Hospiten Hospitals, Tenerife, Spain.Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, Tenerife, Spain.Department of Cell Biology and Histology UFI11/44, School of Medicine and Dentistry, University of the Basque Country, UPV/EHU, Leioa, Spain.Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, Tenerife, Spain.Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, Tenerife, Spain.Department of Cell Biology and Histology, School of Medicine, Regional Campus of International Excellence. "Campus Mare Nostrum", University of Murcia, Espinardo, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31228317

Citation

Díaz-Flores, Lucio, et al. "Intussusceptive Lymphangiogenesis in Lymphatic Malformations/Lymphangiomas." Anatomical Record (Hoboken, N.J. : 2007), vol. 302, no. 11, 2019, pp. 2003-2013.
Díaz-Flores L, Gutiérrez R, García MDP, et al. Intussusceptive Lymphangiogenesis in Lymphatic Malformations/Lymphangiomas. Anat Rec (Hoboken). 2019;302(11):2003-2013.
Díaz-Flores, L., Gutiérrez, R., García, M. D. P., Carrasco, J. L., Sáez, F. J., Díaz-Flores, L., ... Madrid, J. F. (2019). Intussusceptive Lymphangiogenesis in Lymphatic Malformations/Lymphangiomas. Anatomical Record (Hoboken, N.J. : 2007), 302(11), pp. 2003-2013. doi:10.1002/ar.24204.
Díaz-Flores L, et al. Intussusceptive Lymphangiogenesis in Lymphatic Malformations/Lymphangiomas. Anat Rec (Hoboken). 2019;302(11):2003-2013. PubMed PMID: 31228317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intussusceptive Lymphangiogenesis in Lymphatic Malformations/Lymphangiomas. AU - Díaz-Flores,Lucio, AU - Gutiérrez,Ricardo, AU - García,Maria D P, AU - Carrasco,José L, AU - Sáez,Francisco J, AU - Díaz-Flores,Lucio,Jr AU - González-Gómez,Miriam, AU - Madrid,Juan F, Y1 - 2019/07/08/ PY - 2018/05/29/received PY - 2019/01/10/revised PY - 2019/03/09/accepted PY - 2019/6/23/pubmed PY - 2019/6/23/medline PY - 2019/6/23/entrez KW - intussusceptive lymphangiogenesis KW - lymphangiomas KW - lymphatic malformations KW - lymphatic vessels SP - 2003 EP - 2013 JF - Anatomical record (Hoboken, N.J. : 2007) JO - Anat Rec (Hoboken) VL - 302 IS - 11 N2 - Intussusception in lymphatic vessels has received less attention than in blood vessels. In tumors and pseudotumors of blood vessels with intravascular papillary structures, including sinusoidal hemangioma and intravascular papillary endothelial hyperplasia, we observed exuberant intussusceptive angiogenesis, as well as the similarity between papillae (term used by pathologists) and pillars/folds (hallmarks of intussusceptive angiogenesis). A similar response could be expected in lymphangiomas (lymphatic malformations and reactive processes rather than tumors) with papillae. The aim of this work is to assess whether papillae/pillars/folds and associated structures (vessel loops and septa) are present in lymphangiomas, and to establish the characteristics and formation of these structures. For this purpose, we selected lymphangiomas with intraluminal papillae (n = 18), including cystic, cavernous, circumscriptum, and progressive types, of which two cases of each type with a greater number of papillae were used for serial histologic sections and immunohistochemistry. The studies showed a) dilated lymphatic spaces giving rise to lymphatic-lymphatic vascular loops, which dissected and encircled perilymphatic structures (interstitial tissue structures/ITSs and pillars/posts), b) ITSs and pillars, surrounded by anti-podoplanin-positive endothelial cells, protruding into the lymphatic spaces (papillary aspect), and c) splitting, remodeling, linear arrangement, and fusion of papillae/pillars/folds, forming papillary networks and septa. In conclusion, as occurs in blood vessel diseases, the development of lymphatic vessel loops, papillae/pillars/folds, and septa (segmentation) supports intussusceptive lymphangiogenesis and suggests a piecemeal form of intussusception. This intussusceptive lymphangiogenesis in lymphatic diseases can provide a basis for further studies of lymphatic intussusception in other conditions, with clinical and therapeutic implications. Anat Rec, 302:2003-2013, 2019. © 2019 American Association for Anatomy. SN - 1932-8494 UR - https://www.unboundmedicine.com/medline/citation/31228317/Intussusceptive_lymphangiogenesis_in_lymphatic_malformations/lymphangiomas L2 - https://doi.org/10.1002/ar.24204 DB - PRIME DP - Unbound Medicine ER -