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Developmental trajectories of the human embryologic brain regions.
Neurosci Lett 2019; 708:134342NL

Abstract

Vertebrate brains commonly consist of five basic embryologic anatomical regions: telencephalon; diencephalon; mesencephalon; metencephalon; and myelencephalon. The proportions of these regions vary widely across species and developmental stages. Investigation of their growth trajectories, therefore, has the potential to provide an understanding of the substrates of inter-species variation in neuroanatomy and function. To investigate the volumetric growth trajectories, structural magnetic resonance imaging (MRI) scans obtained from 618 healthy children (334 boys, 284 girls; ages 3-17 years old) were parcellated into five regions for the volume quantification. The sex- and region-specific growth trajectories were identified, and the most active growth was seen in the mesencephalon for both boys and girls. Whether similar regional growth patterns are seen in other species, or whether such patterns are related to evolution, are important questions that must be elucidated in the future.

Authors+Show Affiliations

Center for Imaging Science, Johns Hopkins University, Baltimore, MD, United States; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States.The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States.The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States.Center for Imaging Science, Johns Hopkins University, Baltimore, MD, United States; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, United States.Center for Imaging Science, Johns Hopkins University, Baltimore, MD, United States; The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States.Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, United States; The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address: koishi@mri.jhu.edu.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31228595

Citation

Oishi, Kumiko, et al. "Developmental Trajectories of the Human Embryologic Brain Regions." Neuroscience Letters, vol. 708, 2019, p. 134342.
Oishi K, Chotiyanonta J, Wu D, et al. Developmental trajectories of the human embryologic brain regions. Neurosci Lett. 2019;708:134342.
Oishi, K., Chotiyanonta, J., Wu, D., Miller, M. I., Mori, S., & Oishi, K. (2019). Developmental trajectories of the human embryologic brain regions. Neuroscience Letters, 708, p. 134342. doi:10.1016/j.neulet.2019.134342.
Oishi K, et al. Developmental Trajectories of the Human Embryologic Brain Regions. Neurosci Lett. 2019 Aug 24;708:134342. PubMed PMID: 31228595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Developmental trajectories of the human embryologic brain regions. AU - Oishi,Kumiko, AU - Chotiyanonta,Jill, AU - Wu,Dan, AU - Miller,Michael I, AU - Mori,Susumu, AU - Oishi,Kenichi, AU - ,, Y1 - 2019/06/19/ PY - 2019/03/13/received PY - 2019/06/17/revised PY - 2019/06/18/accepted PY - 2020/08/24/pmc-release PY - 2019/6/23/pubmed PY - 2019/6/23/medline PY - 2019/6/23/entrez KW - Atlas KW - Child KW - Diencephalon KW - Magnetic resonance imaging KW - Mesencephalon KW - Metencephalon KW - Myelencephalon KW - Telencephalon SP - 134342 EP - 134342 JF - Neuroscience letters JO - Neurosci. Lett. VL - 708 N2 - Vertebrate brains commonly consist of five basic embryologic anatomical regions: telencephalon; diencephalon; mesencephalon; metencephalon; and myelencephalon. The proportions of these regions vary widely across species and developmental stages. Investigation of their growth trajectories, therefore, has the potential to provide an understanding of the substrates of inter-species variation in neuroanatomy and function. To investigate the volumetric growth trajectories, structural magnetic resonance imaging (MRI) scans obtained from 618 healthy children (334 boys, 284 girls; ages 3-17 years old) were parcellated into five regions for the volume quantification. The sex- and region-specific growth trajectories were identified, and the most active growth was seen in the mesencephalon for both boys and girls. Whether similar regional growth patterns are seen in other species, or whether such patterns are related to evolution, are important questions that must be elucidated in the future. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/31228595/Developmental_trajectories_of_the_human_embryologic_brain_regions L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(19)30442-2 DB - PRIME DP - Unbound Medicine ER -