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Pcv-aCO2/Ca-cvO2 Combined With Arterial Lactate Clearance Rate as Early Resuscitation Goals in Septic Shock.
Am J Med Sci. 2019 09; 358(3):182-190.AJ

Abstract

BACKGROUND

We aimed to investigate the prognostic significance of central venous-arterial carbon dioxide tension to arterial-central venous oxygen content ratio (Pcv-aCO2/Ca-cvO2) combined with arterial lactate clearance rate (LCR) as early resuscitation goals in septic shock.

MATERIALS AND METHODS

We enrolled 145 septic shock patients admitted to our department from March 2013 to May 2017 in this study. They all received an initial resuscitation therapy according to the Surviving Sepsis Campaign guideline, and were classified into 4 groups according to Pcv-aCO2/Ca-cvO2 and LCR at 6 hours after resuscitation (T6): Group A: Pcv-aCO2/Ca-cvO2 > 1.8, LCR < 30%; Group B: Pcv-aCO2/Ca-cvO2 > 1.8, LCR ≥ 30%; Group C: Pcv-aCO2/Ca-cvO2 ≤ 1.8, LCR < 30% and Group D: Pcv-aCO2/Ca-cvO2 ≤ 1.8, LCR ≥ 30%. General demographics, hemodynamic parameters, metabolic parameters, Acute Physiology and Chronic Health Evaluation II scores, Sequential Organ Failure Assessment scores, length of intensive care unit stay and 28-day mortality were compared among groups.

RESULTS

Group D had the lowest Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment score at day 3, the shortest intensive care unit stay and the lowest 28-day mortality. Kaplan-Meier survival curves up to day 28 showed group D had the longest median survival time. Pcv-aCO2/Ca-cvO2 and LCR at T6 were independent predictors of 28-day mortality. The area under ROC curve for Pcv-aCO2/Ca-cvO2 combined with LCR was significantly greater than either Pcv-aCO2/Ca-cvO2 or LCR alone (both P < 0.05).

CONCLUSIONS

Combination of Pcv-aCO2/Ca-cvO2 ratio and LCR is better than either alone to predict the adverse outcomes in septic shock, and may provide useful information for assessing the adequacy of resuscitation in early-stage septic shock.

Authors+Show Affiliations

Department of Critical Care Medicine, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China.Department of Critical Care Medicine, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China.Department of Critical Care Medicine, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China. Electronic address: lipeijielanzhou@hotmail.com.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31229247

Citation

Gao, Xuehua, et al. "Pcv-aCO2/Ca-cvO2 Combined With Arterial Lactate Clearance Rate as Early Resuscitation Goals in Septic Shock." The American Journal of the Medical Sciences, vol. 358, no. 3, 2019, pp. 182-190.
Gao X, Cao W, Li P. Pcv-aCO2/Ca-cvO2 Combined With Arterial Lactate Clearance Rate as Early Resuscitation Goals in Septic Shock. Am J Med Sci. 2019;358(3):182-190.
Gao, X., Cao, W., & Li, P. (2019). Pcv-aCO2/Ca-cvO2 Combined With Arterial Lactate Clearance Rate as Early Resuscitation Goals in Septic Shock. The American Journal of the Medical Sciences, 358(3), 182-190. https://doi.org/10.1016/j.amjms.2019.04.025
Gao X, Cao W, Li P. Pcv-aCO2/Ca-cvO2 Combined With Arterial Lactate Clearance Rate as Early Resuscitation Goals in Septic Shock. Am J Med Sci. 2019;358(3):182-190. PubMed PMID: 31229247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pcv-aCO2/Ca-cvO2 Combined With Arterial Lactate Clearance Rate as Early Resuscitation Goals in Septic Shock. AU - Gao,Xuehua, AU - Cao,Wen, AU - Li,Peijie, Y1 - 2019/05/06/ PY - 2018/09/30/received PY - 2019/04/28/revised PY - 2019/04/29/accepted PY - 2019/6/24/pubmed PY - 2020/4/3/medline PY - 2019/6/24/entrez KW - Arterial-central venous oxygen content difference KW - Central venous-arterial carbon dioxide difference KW - Lactic clearance rate KW - Septic shock SP - 182 EP - 190 JF - The American journal of the medical sciences JO - Am J Med Sci VL - 358 IS - 3 N2 - BACKGROUND: We aimed to investigate the prognostic significance of central venous-arterial carbon dioxide tension to arterial-central venous oxygen content ratio (Pcv-aCO2/Ca-cvO2) combined with arterial lactate clearance rate (LCR) as early resuscitation goals in septic shock. MATERIALS AND METHODS: We enrolled 145 septic shock patients admitted to our department from March 2013 to May 2017 in this study. They all received an initial resuscitation therapy according to the Surviving Sepsis Campaign guideline, and were classified into 4 groups according to Pcv-aCO2/Ca-cvO2 and LCR at 6 hours after resuscitation (T6): Group A: Pcv-aCO2/Ca-cvO2 > 1.8, LCR < 30%; Group B: Pcv-aCO2/Ca-cvO2 > 1.8, LCR ≥ 30%; Group C: Pcv-aCO2/Ca-cvO2 ≤ 1.8, LCR < 30% and Group D: Pcv-aCO2/Ca-cvO2 ≤ 1.8, LCR ≥ 30%. General demographics, hemodynamic parameters, metabolic parameters, Acute Physiology and Chronic Health Evaluation II scores, Sequential Organ Failure Assessment scores, length of intensive care unit stay and 28-day mortality were compared among groups. RESULTS: Group D had the lowest Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment score at day 3, the shortest intensive care unit stay and the lowest 28-day mortality. Kaplan-Meier survival curves up to day 28 showed group D had the longest median survival time. Pcv-aCO2/Ca-cvO2 and LCR at T6 were independent predictors of 28-day mortality. The area under ROC curve for Pcv-aCO2/Ca-cvO2 combined with LCR was significantly greater than either Pcv-aCO2/Ca-cvO2 or LCR alone (both P < 0.05). CONCLUSIONS: Combination of Pcv-aCO2/Ca-cvO2 ratio and LCR is better than either alone to predict the adverse outcomes in septic shock, and may provide useful information for assessing the adequacy of resuscitation in early-stage septic shock. SN - 1538-2990 UR - https://www.unboundmedicine.com/medline/citation/31229247/Pcv_aCO2/Ca_cvO2_Combined_With_Arterial_Lactate_Clearance_Rate_as_Early_Resuscitation_Goals_in_Septic_Shock_ DB - PRIME DP - Unbound Medicine ER -