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Potential of dehydroepiandrosterone in modulating osteoarthritis-related pain.

Abstract

Osteoarthritis (OA) is the most common form of degenerative arthropathy, and the primary symptom is chronic joint pain. Dehydroepiandrosterone (DHEA) exerts a chondroprotective effect against OA and has been reported to have potent structure-modifying effects on osteoarthritic cartilage, thereby attenuating disease progression. However, the ability of DHEA to modulate OA-related pain has not yet been verified. Recent evidence suggests that there may be a link between the pharmacological effects of DHEA and pain generation. For example, DHEA synthesized in the adrenal gland interferes directly with nerve growth factor (NGF) receptors, a major biochemical contributor to peripheral hypersensitivity. Similarly, endogenous DHEA produced in the spinal cord exerts a regulatory effect on nociception in neuropathic rats. In this short review, we discuss recent studies concerning crucial signalling cascades and molecular mechanisms involved in pain generation as well as the potential link between DHEA activity and nociception. Particular attention is given to the putative molecular mechanisms underlying the favourable efficacy of DHEA against pain generation. Elucidating the molecular mechanisms of DHEA against osteoarthritic pain may pave the way for the discovery and development of novel anti-OA drugs, as effective drugs for OA treatment are not currently available.

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  • Authors+Show Affiliations

    ,

    Department of Orthopedic Surgery, Tongde Hospital of Zhejiang Province, Hangzhou 310012, PR China. Electronic address: hzhuangk@163.com.

    ,

    Department of Ultrasound, The 903rd Hospital of PLA, Hangzhou 310012, PR China.

    Department of Orthopedic Surgery, The Second Hospital of Medical College, Zhejiang University, Hangzhou 310009, PR China.

    Source

    Steroids 150: 2019 Jun 21 pg 108433

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    31229511

    Citation

    Huang, Kai, et al. "Potential of Dehydroepiandrosterone in Modulating Osteoarthritis-related Pain." Steroids, vol. 150, 2019, p. 108433.
    Huang K, Cai HL, Wu LD. Potential of dehydroepiandrosterone in modulating osteoarthritis-related pain. Steroids. 2019;150:108433.
    Huang, K., Cai, H. L., & Wu, L. D. (2019). Potential of dehydroepiandrosterone in modulating osteoarthritis-related pain. Steroids, 150, p. 108433. doi:10.1016/j.steroids.2019.108433.
    Huang K, Cai HL, Wu LD. Potential of Dehydroepiandrosterone in Modulating Osteoarthritis-related Pain. Steroids. 2019 Jun 21;150:108433. PubMed PMID: 31229511.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Potential of dehydroepiandrosterone in modulating osteoarthritis-related pain. AU - Huang,Kai, AU - Cai,Hai-Li, AU - Wu,Li-Dong, Y1 - 2019/06/21/ PY - 2019/03/02/received PY - 2019/06/11/revised PY - 2019/06/18/accepted PY - 2019/6/24/pubmed PY - 2019/6/24/medline PY - 2019/6/24/entrez KW - Dehydroepiandrosterone KW - Osteoarthritis KW - Pain generation SP - 108433 EP - 108433 JF - Steroids JO - Steroids VL - 150 N2 - Osteoarthritis (OA) is the most common form of degenerative arthropathy, and the primary symptom is chronic joint pain. Dehydroepiandrosterone (DHEA) exerts a chondroprotective effect against OA and has been reported to have potent structure-modifying effects on osteoarthritic cartilage, thereby attenuating disease progression. However, the ability of DHEA to modulate OA-related pain has not yet been verified. Recent evidence suggests that there may be a link between the pharmacological effects of DHEA and pain generation. For example, DHEA synthesized in the adrenal gland interferes directly with nerve growth factor (NGF) receptors, a major biochemical contributor to peripheral hypersensitivity. Similarly, endogenous DHEA produced in the spinal cord exerts a regulatory effect on nociception in neuropathic rats. In this short review, we discuss recent studies concerning crucial signalling cascades and molecular mechanisms involved in pain generation as well as the potential link between DHEA activity and nociception. Particular attention is given to the putative molecular mechanisms underlying the favourable efficacy of DHEA against pain generation. Elucidating the molecular mechanisms of DHEA against osteoarthritic pain may pave the way for the discovery and development of novel anti-OA drugs, as effective drugs for OA treatment are not currently available. SN - 1878-5867 UR - https://www.unboundmedicine.com/medline/citation/31229511/Potential_of_dehydroepiandrosterone_in_modulating_osteoarthritis-related_pain L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-128X(19)30123-0 DB - PRIME DP - Unbound Medicine ER -