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Joint effects of zinc oxide nanoparticles and chlorpyrifos on the reproduction and cellular stress responses of the earthworm Eisenia andrei.
Sci Total Environ. 2019 Oct 20; 688:199-207.ST

Abstract

The co-exposure of soil organisms to ZnO nanoparticles (ZnO NPs) and pesticides is likely to take place in agricultural soils. However, the impacts of co-exposure on terrestrial ecosystems are virtually unknown. In this paper, Eisenia andrei was exposed for a 28-day period to serial concentrations of ZnO NPs and/or the organophosphate insecticide chlorpyrifos (CPF) in natural soil, and was evaluated for single and joint effects. Zn and CPF accumulation in earthworm tissue was also determined. In the single assay, ZnO NPs and CPF caused statistical significant effects on survival and growth, but mainly on reproduction. Significant reductions in fecundity and fertility were detected with EC50 values of 278 and 179 mg Zn/kg for ZnO NPs, and of 50.75 and 38.24 mg/kg for CPF, respectively. The most notable effect on biomarkers was the reduction in acetylcholinesterase (AChE) activity caused by CPF, which reflected the neurotoxicity of this compound. The results of the combined assay indicated that co-exposure to ZnO NPs and CPF increased adverse effects in E. andrei. According to the independent action model, the binary mixtures showed a synergism (a stronger effect than expected from single exposures) on earthworm reproduction, which became up to 84% higher than the theoretically predicted values. Zn, and especially CPF accumulation, were influenced by the co-exposure. These results underpin the need to consider the effects of mixtures of NPs and organic chemicals on soil to adequately make ecological risk assessments of NPs.

Authors+Show Affiliations

Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Environment Department, Ctra. A Coruña, km 7.5, 28040 Madrid, (Spain). Electronic address: cgarcia@inia.es.Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Environment Department, Ctra. A Coruña, km 7.5, 28040 Madrid, (Spain). Electronic address: babin@inia.es.Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Environment Department, Ctra. A Coruña, km 7.5, 28040 Madrid, (Spain). Electronic address: sandra.garcia@inia.es.Universidad Politécnica de Madrid (UPM), Chemical and Food Technology Department, CEIGRAM, Research Centre for the Management of Agricultural and Environmental Risks, Madrid, 28040, Spain. Electronic address: p.almendros@upm.es.Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Environment Department, Ctra. A Coruña, km 7.5, 28040 Madrid, (Spain). Electronic address: Perez.rosana@inia.es.Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Environment Department, Ctra. A Coruña, km 7.5, 28040 Madrid, (Spain). Electronic address: mdfdez@inia.es.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31229817

Citation

García-Gómez, Concepción, et al. "Joint Effects of Zinc Oxide Nanoparticles and Chlorpyrifos On the Reproduction and Cellular Stress Responses of the Earthworm Eisenia Andrei." The Science of the Total Environment, vol. 688, 2019, pp. 199-207.
García-Gómez C, Babín M, García S, et al. Joint effects of zinc oxide nanoparticles and chlorpyrifos on the reproduction and cellular stress responses of the earthworm Eisenia andrei. Sci Total Environ. 2019;688:199-207.
García-Gómez, C., Babín, M., García, S., Almendros, P., Pérez, R. A., & Fernández, M. D. (2019). Joint effects of zinc oxide nanoparticles and chlorpyrifos on the reproduction and cellular stress responses of the earthworm Eisenia andrei. The Science of the Total Environment, 688, 199-207. https://doi.org/10.1016/j.scitotenv.2019.06.083
García-Gómez C, et al. Joint Effects of Zinc Oxide Nanoparticles and Chlorpyrifos On the Reproduction and Cellular Stress Responses of the Earthworm Eisenia Andrei. Sci Total Environ. 2019 Oct 20;688:199-207. PubMed PMID: 31229817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Joint effects of zinc oxide nanoparticles and chlorpyrifos on the reproduction and cellular stress responses of the earthworm Eisenia andrei. AU - García-Gómez,Concepción, AU - Babín,Mar, AU - García,Sandra, AU - Almendros,Patricia, AU - Pérez,Rosa Ana, AU - Fernández,María Dolores, Y1 - 2019/06/15/ PY - 2018/10/26/received PY - 2019/06/05/revised PY - 2019/06/05/accepted PY - 2019/6/24/pubmed PY - 2019/11/9/medline PY - 2019/6/24/entrez KW - Chlorpyrifos KW - Combined toxicity KW - Earthworm KW - Soil KW - ZnO nanoparticles SP - 199 EP - 207 JF - The Science of the total environment JO - Sci Total Environ VL - 688 N2 - The co-exposure of soil organisms to ZnO nanoparticles (ZnO NPs) and pesticides is likely to take place in agricultural soils. However, the impacts of co-exposure on terrestrial ecosystems are virtually unknown. In this paper, Eisenia andrei was exposed for a 28-day period to serial concentrations of ZnO NPs and/or the organophosphate insecticide chlorpyrifos (CPF) in natural soil, and was evaluated for single and joint effects. Zn and CPF accumulation in earthworm tissue was also determined. In the single assay, ZnO NPs and CPF caused statistical significant effects on survival and growth, but mainly on reproduction. Significant reductions in fecundity and fertility were detected with EC50 values of 278 and 179 mg Zn/kg for ZnO NPs, and of 50.75 and 38.24 mg/kg for CPF, respectively. The most notable effect on biomarkers was the reduction in acetylcholinesterase (AChE) activity caused by CPF, which reflected the neurotoxicity of this compound. The results of the combined assay indicated that co-exposure to ZnO NPs and CPF increased adverse effects in E. andrei. According to the independent action model, the binary mixtures showed a synergism (a stronger effect than expected from single exposures) on earthworm reproduction, which became up to 84% higher than the theoretically predicted values. Zn, and especially CPF accumulation, were influenced by the co-exposure. These results underpin the need to consider the effects of mixtures of NPs and organic chemicals on soil to adequately make ecological risk assessments of NPs. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/31229817/Joint_effects_of_zinc_oxide_nanoparticles_and_chlorpyrifos_on_the_reproduction_and_cellular_stress_responses_of_the_earthworm_Eisenia_andrei_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(19)32651-8 DB - PRIME DP - Unbound Medicine ER -