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Associations and effects of omega-3 polyunsaturated fatty acids on cognitive function and mood in healthy adults: a protocol for a systematic review of observational and interventional studies.
BMJ Open. 2019 06 22; 9(6):e027167.BO

Abstract

INTRODUCTION

The association between long-chain omega-3 polyunsaturated fatty acids (PUFAs), brain health, cognitive function and mood has been the subject of intensive research. Marine-derived omega-3 PUFAs, such as docosahexaenoic acid and eicosapentaenoic acid, are highly concentrated in neuronal membranes and affect brain function. Many studies have found that consumption of omega-3 PUFAs is associated with lower risk of cognitive or mood dysfunction. However, other studies have demonstrated no beneficial effects. There appears to be inconsistent findings from both epidemiological and randomised controlled trial (RCT) studies. The aim of this review is to compile the previous literature and establish the efficacy of omega-3 PUFAs in enhancing cognitive performance and mood in healthy adults.

METHODS AND ANALYSIS

Prospective cohort studies, RCTs, controlled clinical trials, controlled before and after studies, interrupted time series with a minimum of 3 months duration will be eligible for inclusion. Studies on healthy adults over the age of 18, where the intervention/exposure of interest is omega-3 PUFAs will be included. The outcomes of interest are cognition and mood. Studies will be eligible for inclusion if they measure changes in cognitive function or mood, or the risk of developing cognitive or mood disorders using validated tools and assessments. Relevant search terms and keywords will be used to generate a systematic search in Cochrane Library, MEDLINE, EMBASE, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Scopus and the grey literature. Two independent reviewers will screen studies for eligibility. Risk of bias in cohort and non-randomised studies will be assessed using the ROBINS-I tool. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials will be used for RCTs. If there are sufficient data, a meta-analysis will be conducted.

ETHICS AND DISSEMINATION

This systematic review does not involve primary data collection and therefore formal ethical approval is not required. Results will be disseminated through peer reviewed publications, conference presentations and the popular press.

PROSPERO REGISTRATION NUMBER

CRD42018080800.

Authors+Show Affiliations

Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland. Food Innovation Department, Devenish Nutrition Ltd, Belfast, UK. Department of Psychology, Beaumont Hospital, Dublin, Ireland.Department of Psychology, Beaumont Hospital, Dublin, Ireland. Academic Unit of Neurology, Trinity College Dublin, Dublin, Ireland.Food Innovation Department, Devenish Nutrition Ltd, Belfast, UK.Food Innovation Department, Devenish Nutrition Ltd, Belfast, UK.Department of Psychology, Beaumont Hospital, Dublin, Ireland.Division of Population Health Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland. Food Innovation Department, Devenish Nutrition Ltd, Belfast, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31230010

Citation

O' Donovan, Fiona, et al. "Associations and Effects of Omega-3 Polyunsaturated Fatty Acids On Cognitive Function and Mood in Healthy Adults: a Protocol for a Systematic Review of Observational and Interventional Studies." BMJ Open, vol. 9, no. 6, 2019, pp. e027167.
O' Donovan F, Carney S, Kennedy J, et al. Associations and effects of omega-3 polyunsaturated fatty acids on cognitive function and mood in healthy adults: a protocol for a systematic review of observational and interventional studies. BMJ Open. 2019;9(6):e027167.
O' Donovan, F., Carney, S., Kennedy, J., Hayes, H., Pender, N., Boland, F., & Stanton, A. (2019). Associations and effects of omega-3 polyunsaturated fatty acids on cognitive function and mood in healthy adults: a protocol for a systematic review of observational and interventional studies. BMJ Open, 9(6), e027167. https://doi.org/10.1136/bmjopen-2018-027167
O' Donovan F, et al. Associations and Effects of Omega-3 Polyunsaturated Fatty Acids On Cognitive Function and Mood in Healthy Adults: a Protocol for a Systematic Review of Observational and Interventional Studies. BMJ Open. 2019 06 22;9(6):e027167. PubMed PMID: 31230010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations and effects of omega-3 polyunsaturated fatty acids on cognitive function and mood in healthy adults: a protocol for a systematic review of observational and interventional studies. AU - O' Donovan,Fiona, AU - Carney,Síle, AU - Kennedy,Jean, AU - Hayes,Heather, AU - Pender,Niall, AU - Boland,Fiona, AU - Stanton,Alice, Y1 - 2019/06/22/ PY - 2019/6/24/entrez PY - 2019/6/24/pubmed PY - 2020/6/9/medline KW - cognition KW - docosahexaenoic acid KW - fish KW - mood KW - omega-3 fatty acids SP - e027167 EP - e027167 JF - BMJ open JO - BMJ Open VL - 9 IS - 6 N2 - INTRODUCTION: The association between long-chain omega-3 polyunsaturated fatty acids (PUFAs), brain health, cognitive function and mood has been the subject of intensive research. Marine-derived omega-3 PUFAs, such as docosahexaenoic acid and eicosapentaenoic acid, are highly concentrated in neuronal membranes and affect brain function. Many studies have found that consumption of omega-3 PUFAs is associated with lower risk of cognitive or mood dysfunction. However, other studies have demonstrated no beneficial effects. There appears to be inconsistent findings from both epidemiological and randomised controlled trial (RCT) studies. The aim of this review is to compile the previous literature and establish the efficacy of omega-3 PUFAs in enhancing cognitive performance and mood in healthy adults. METHODS AND ANALYSIS: Prospective cohort studies, RCTs, controlled clinical trials, controlled before and after studies, interrupted time series with a minimum of 3 months duration will be eligible for inclusion. Studies on healthy adults over the age of 18, where the intervention/exposure of interest is omega-3 PUFAs will be included. The outcomes of interest are cognition and mood. Studies will be eligible for inclusion if they measure changes in cognitive function or mood, or the risk of developing cognitive or mood disorders using validated tools and assessments. Relevant search terms and keywords will be used to generate a systematic search in Cochrane Library, MEDLINE, EMBASE, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Scopus and the grey literature. Two independent reviewers will screen studies for eligibility. Risk of bias in cohort and non-randomised studies will be assessed using the ROBINS-I tool. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials will be used for RCTs. If there are sufficient data, a meta-analysis will be conducted. ETHICS AND DISSEMINATION: This systematic review does not involve primary data collection and therefore formal ethical approval is not required. Results will be disseminated through peer reviewed publications, conference presentations and the popular press. PROSPERO REGISTRATION NUMBER: CRD42018080800. SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/31230010/Associations_and_effects_of_omega_3_polyunsaturated_fatty_acids_on_cognitive_function_and_mood_in_healthy_adults:_a_protocol_for_a_systematic_review_of_observational_and_interventional_studies_ L2 - http://bmjopen.bmj.com/cgi/pmidlookup?view=long&pmid=31230010 DB - PRIME DP - Unbound Medicine ER -