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Heyde Syndrome: Aortic Stenosis and Beyond.
Clin Geriatr Med 2019; 35(3):369-379CG

Abstract

Heyde described aortic stenosis and gastrointestinal bleeding in the 1950s. Since then, a link with intestinal angiodysplasia and abnormalities of von Willebrand factor (VWF) has been noted. Loss of the highest-molecular-weight multimers of VWF and bleeding also have been described in subaortic stenosis in hypertrophic cardiomyopathy, in isolated mitral and aortic insufficiency, in endocarditis, in patients with prosthetic valve stenosis or regurgitation, and in patients with left ventricular assist devices (LVADs). Bleeding tends to recur with local treatment of angiodysplasias, whereas cardiac repair or removal of LVAD eliminates VWF dysfunction is curative of bleeding in the majority.

Authors+Show Affiliations

Department of Cardiovascular Diseases, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Electronic address: blackshear.joseph@mayo.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31230737

Citation

Blackshear, Joseph L.. "Heyde Syndrome: Aortic Stenosis and Beyond." Clinics in Geriatric Medicine, vol. 35, no. 3, 2019, pp. 369-379.
Blackshear JL. Heyde Syndrome: Aortic Stenosis and Beyond. Clin Geriatr Med. 2019;35(3):369-379.
Blackshear, J. L. (2019). Heyde Syndrome: Aortic Stenosis and Beyond. Clinics in Geriatric Medicine, 35(3), pp. 369-379. doi:10.1016/j.cger.2019.03.007.
Blackshear JL. Heyde Syndrome: Aortic Stenosis and Beyond. Clin Geriatr Med. 2019;35(3):369-379. PubMed PMID: 31230737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heyde Syndrome: Aortic Stenosis and Beyond. A1 - Blackshear,Joseph L, Y1 - 2019/05/27/ PY - 2019/6/25/entrez KW - Acquired von Willebrand syndrome KW - Angiodysplasia KW - Aortic stenosis KW - Gastrointestinal bleeding KW - Heyde syndrome KW - von Willebrand factor SP - 369 EP - 379 JF - Clinics in geriatric medicine JO - Clin. Geriatr. Med. VL - 35 IS - 3 N2 - Heyde described aortic stenosis and gastrointestinal bleeding in the 1950s. Since then, a link with intestinal angiodysplasia and abnormalities of von Willebrand factor (VWF) has been noted. Loss of the highest-molecular-weight multimers of VWF and bleeding also have been described in subaortic stenosis in hypertrophic cardiomyopathy, in isolated mitral and aortic insufficiency, in endocarditis, in patients with prosthetic valve stenosis or regurgitation, and in patients with left ventricular assist devices (LVADs). Bleeding tends to recur with local treatment of angiodysplasias, whereas cardiac repair or removal of LVAD eliminates VWF dysfunction is curative of bleeding in the majority. SN - 1879-8853 UR - https://www.unboundmedicine.com/medline/citation/31230737/Heyde_Syndrome:_Aortic_Stenosis_and_Beyond L2 - https://linkinghub.elsevier.com/retrieve/pii/S0749-0690(19)30030-8 DB - PRIME DP - Unbound Medicine ER -