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Effective contraception with the levonorgestrel-releasing intrauterine device: 12-month report of a European multicenter study.
Contraception. 1987 Aug; 36(2):169-79.C

Abstract

The use-effectiveness of an intrauterine contraceptive device releasing 20 mcg of levonorgestrel daily (Lng-IUD), and of a Nova T copper-releasing IUD, were studied in a randomized, comparative multicenter trial. The Lng-IUD was inserted in 1821, and the Nova T in 937 women. The 12-month net pregnancy rate with the Lng-IUD (0.1 per hundred women) was significantly lower than that with the Nova T (0.9 per hundred). Removal rates for menstrual problems and/or pain were similar for the two methods (net rates 7.5 and 8.7, respectively). The 12-month continuation rates were 82.2 for the Nova T and 79.7 for the Lng-IUD. The reduction of the bleeding led to oligomenorrhea and amenorrhea in users of the Lng-IUD; the removal rate for these reasons was 1.4. The removal rate for hormonal side effects with the Lng-IUD was 2.4. Blood hemoglobin concentrations increased among users of the Lng-IUD and decreased among users of the Nova T. The results show that the Lng-IUD was a highly effective contraceptive method which reduced menstrual bleeding. It is a promising alternative for women desiring a highly effective method for long-term use.

Authors+Show Affiliations

City Maternity Hospital, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

3123132

Citation

Luukkainen, T, et al. "Effective Contraception With the Levonorgestrel-releasing Intrauterine Device: 12-month Report of a European Multicenter Study." Contraception, vol. 36, no. 2, 1987, pp. 169-79.
Luukkainen T, Allonen H, Haukkamaa M, et al. Effective contraception with the levonorgestrel-releasing intrauterine device: 12-month report of a European multicenter study. Contraception. 1987;36(2):169-79.
Luukkainen, T., Allonen, H., Haukkamaa, M., Holma, P., Pyörälä, T., Terho, J., Toivonen, J., Batar, I., Lampe, L., & Andersson, K. (1987). Effective contraception with the levonorgestrel-releasing intrauterine device: 12-month report of a European multicenter study. Contraception, 36(2), 169-79.
Luukkainen T, et al. Effective Contraception With the Levonorgestrel-releasing Intrauterine Device: 12-month Report of a European Multicenter Study. Contraception. 1987;36(2):169-79. PubMed PMID: 3123132.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effective contraception with the levonorgestrel-releasing intrauterine device: 12-month report of a European multicenter study. A1 - Luukkainen,T, AU - Allonen,H, AU - Haukkamaa,M, AU - Holma,P, AU - Pyörälä,T, AU - Terho,J, AU - Toivonen,J, AU - Batar,I, AU - Lampe,L, AU - Andersson,K, PY - 1987/8/1/pubmed PY - 1987/8/1/medline PY - 1987/8/1/entrez KW - Biology KW - Clinical Research KW - Comparative Studies KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Denmark KW - Developed Countries KW - Diseases KW - Eastern Europe KW - Endocrine System KW - Europe KW - Evaluation KW - Examinations And Diagnoses KW - Family Planning KW - Finland KW - Genital Effects, Female KW - Genitalia KW - Genitalia, Female KW - Hormones--side effects KW - Hungary KW - Iud KW - Iud, Copper Releasing KW - Levonorgestrel KW - Menstruation Disorders KW - Northern Europe KW - Norway KW - Physiology KW - Reproductive Control Agents KW - Research Methodology KW - Research Report KW - Retention KW - Scandinavia KW - Studies KW - Sweden KW - Urogenital System SP - 169 EP - 79 JF - Contraception JO - Contraception VL - 36 IS - 2 N2 - The use-effectiveness of an intrauterine contraceptive device releasing 20 mcg of levonorgestrel daily (Lng-IUD), and of a Nova T copper-releasing IUD, were studied in a randomized, comparative multicenter trial. The Lng-IUD was inserted in 1821, and the Nova T in 937 women. The 12-month net pregnancy rate with the Lng-IUD (0.1 per hundred women) was significantly lower than that with the Nova T (0.9 per hundred). Removal rates for menstrual problems and/or pain were similar for the two methods (net rates 7.5 and 8.7, respectively). The 12-month continuation rates were 82.2 for the Nova T and 79.7 for the Lng-IUD. The reduction of the bleeding led to oligomenorrhea and amenorrhea in users of the Lng-IUD; the removal rate for these reasons was 1.4. The removal rate for hormonal side effects with the Lng-IUD was 2.4. Blood hemoglobin concentrations increased among users of the Lng-IUD and decreased among users of the Nova T. The results show that the Lng-IUD was a highly effective contraceptive method which reduced menstrual bleeding. It is a promising alternative for women desiring a highly effective method for long-term use. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/3123132/Effective_contraception_with_the_levonorgestrel_releasing_intrauterine_device:_12_month_report_of_a_European_multicenter_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(87)90012-6 DB - PRIME DP - Unbound Medicine ER -