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Temporal lobe "plus" epilepsy associated with oligodendroglial hyperplasia (MOGHE).

Abstract

BACKGROUND

Mild malformation of cortical dysplasia (mMCD) with oligodendroglial hyperplasia (MOGHE) is an epilepsy-related pathologic entity highlighted in post-surgical specimens of frontal lobe epilepsy (FLE) patients.

AIMS OF THE STUDY

We present two temporal lobe epilepsy (TLE) cases with MOGHE and discuss clinical, neurophysiological, and neuroimaging features that may be indicative of surgical outcome.

METHODS

We identified two cases with MOGHE out of 30 temporal lobe epilepsy (TLE) surgical patient cohort, whose pathological distribution spared the hippocampal structures.

RESULTS

The TLE cases shared common features with the FLE series in terms of patient profiles, MRI findings and post-surgical outcome. TLE plus seizure semiology combined with extratemporal scalp electroencephalographic (EEG) and electrocorticographic (ECoG) epileptiform elements at a distance from the imaging lesion were suggestive of an underlying multifocal pathology.

CONCLUSIONS

MOGHE pathology has to be considered in the decision-making process for TLE epilepsy surgery when this constellation of features is met.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Epilepsy Center of Thessaloniki, "St. Luke's" Hospital, Thessaloniki, Greece.

    ,

    Epilepsy Center of Thessaloniki, "St. Luke's" Hospital, Thessaloniki, Greece. Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

    ,

    Epilepsy Center of Thessaloniki, "St. Luke's" Hospital, Thessaloniki, Greece.

    ,

    Third Department of Pediatrics, "Attikon" University Hospital, National & Kapodistrian University of Athens, Athens, Greece.

    ,

    Neuropathologisches Institut, Universikätsklinikum, Erlangen, Germany.

    Neuropathologisches Institut, Universikätsklinikum, Erlangen, Germany.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31231790

    Citation

    Garganis, Kyriakos, et al. "Temporal Lobe "plus" Epilepsy Associated With Oligodendroglial Hyperplasia (MOGHE)." Acta Neurologica Scandinavica, 2019.
    Garganis K, Kokkinos V, Zountsas B, et al. Temporal lobe "plus" epilepsy associated with oligodendroglial hyperplasia (MOGHE). Acta Neurol Scand. 2019.
    Garganis, K., Kokkinos, V., Zountsas, B., Dinopoulos, A., Coras, R., & Blümcke, I. (2019). Temporal lobe "plus" epilepsy associated with oligodendroglial hyperplasia (MOGHE). Acta Neurologica Scandinavica, doi:10.1111/ane.13142.
    Garganis K, et al. Temporal Lobe "plus" Epilepsy Associated With Oligodendroglial Hyperplasia (MOGHE). Acta Neurol Scand. 2019 Jun 24; PubMed PMID: 31231790.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Temporal lobe "plus" epilepsy associated with oligodendroglial hyperplasia (MOGHE). AU - Garganis,Kyriakos, AU - Kokkinos,Vasileios, AU - Zountsas,Basilios, AU - Dinopoulos,Argirios, AU - Coras,Roland, AU - Blümcke,Ingmar, Y1 - 2019/06/24/ PY - 2019/03/10/received PY - 2019/06/04/revised PY - 2019/06/20/accepted PY - 2019/6/25/pubmed PY - 2019/6/25/medline PY - 2019/6/25/entrez KW - MRI KW - epilepsy surgery KW - histopathology KW - mild malformation of cortical development with oligodendroglial hyperplasia KW - temporal lobe plus epilepsy JF - Acta neurologica Scandinavica JO - Acta Neurol. Scand. N2 - BACKGROUND: Mild malformation of cortical dysplasia (mMCD) with oligodendroglial hyperplasia (MOGHE) is an epilepsy-related pathologic entity highlighted in post-surgical specimens of frontal lobe epilepsy (FLE) patients. AIMS OF THE STUDY: We present two temporal lobe epilepsy (TLE) cases with MOGHE and discuss clinical, neurophysiological, and neuroimaging features that may be indicative of surgical outcome. METHODS: We identified two cases with MOGHE out of 30 temporal lobe epilepsy (TLE) surgical patient cohort, whose pathological distribution spared the hippocampal structures. RESULTS: The TLE cases shared common features with the FLE series in terms of patient profiles, MRI findings and post-surgical outcome. TLE plus seizure semiology combined with extratemporal scalp electroencephalographic (EEG) and electrocorticographic (ECoG) epileptiform elements at a distance from the imaging lesion were suggestive of an underlying multifocal pathology. CONCLUSIONS: MOGHE pathology has to be considered in the decision-making process for TLE epilepsy surgery when this constellation of features is met. SN - 1600-0404 UR - https://www.unboundmedicine.com/medline/citation/31231790/Temporal_lobe_"plus"_epilepsy_associated_with_oligodendroglial_hyperplasia_(MOGHE) L2 - https://doi.org/10.1111/ane.13142 DB - PRIME DP - Unbound Medicine ER -