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Retracted: Expression of Lymphocyte-Activation Gene 3 (LAG-3) Immune Checkpoint Receptor Identifies a Tumor-Reactive T Cell Population in the Peripheral Blood of Patients with Colorectal Cancer.
Med Sci Monit 2019; 25:4400MS

Abstract

This article is retracted due to authors' claims in regards to errors in data and statistical analyses. Authors' message: We greatly regret to inform you that we just discovered some fatal errors in the statistical analysis, in which we mistakenly used the cultured cells TCR sequencing data as the results of CD8+ LAG3+ and CD8 LAG3-T cells. Therefore, the current results and data have serious defects and do not accurately represent the sorted cells. On behalf of all the contributing authors of the manuscript, we have decided to immediately retract the manuscript titled "LAG-3 receptor identifies a higher tumor-reactive cell population in the peripheral blood of colorectal cancer patients" to avoid further problems.

Authors+Show Affiliations

Department of Medical Oncology, Beijing Key Laboratory for Therapeutic Cancer Vaccines, Capital Medical University Cancer Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China (mainland).Department of Medical Oncology, Beijing Key Laboratory for Therapeutic Cancer Vaccines, Capital Medical University Cancer Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, CA, China (mainland).Department of Medical Oncology, Beijing Key Laboratory for Therapeutic Cancer Vaccines, Capital Medical University Cancer Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China (mainland).Department of Medical Oncology, Beijing Key Laboratory for Therapeutic Cancer Vaccines, Capital Medical University Cancer Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China (mainland).

Pub Type(s)

Journal Article
Retraction of Publication

Language

eng

PubMed ID

31233010

Citation

Huang, Lefu, et al. "Retracted: Expression of Lymphocyte-Activation Gene 3 (LAG-3) Immune Checkpoint Receptor Identifies a Tumor-Reactive T Cell Population in the Peripheral Blood of Patients With Colorectal Cancer." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 25, 2019, p. 4400.
Huang L, Qiao G, Wu J, et al. Retracted: Expression of Lymphocyte-Activation Gene 3 (LAG-3) Immune Checkpoint Receptor Identifies a Tumor-Reactive T Cell Population in the Peripheral Blood of Patients with Colorectal Cancer. Med Sci Monit. 2019;25:4400.
Huang, L., Qiao, G., Wu, J., & Ren, J. (2019). Retracted: Expression of Lymphocyte-Activation Gene 3 (LAG-3) Immune Checkpoint Receptor Identifies a Tumor-Reactive T Cell Population in the Peripheral Blood of Patients with Colorectal Cancer. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 25, p. 4400. doi:10.12659/MSM.917907.
Huang L, et al. Retracted: Expression of Lymphocyte-Activation Gene 3 (LAG-3) Immune Checkpoint Receptor Identifies a Tumor-Reactive T Cell Population in the Peripheral Blood of Patients With Colorectal Cancer. Med Sci Monit. 2019 06 13;25:4400. PubMed PMID: 31233010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retracted: Expression of Lymphocyte-Activation Gene 3 (LAG-3) Immune Checkpoint Receptor Identifies a Tumor-Reactive T Cell Population in the Peripheral Blood of Patients with Colorectal Cancer. AU - Huang,Lefu, AU - Qiao,Guoliang, AU - Wu,Jingping, AU - Ren,Jun, Y1 - 2019/06/13/ PY - 2019/6/25/entrez PY - 2019/6/25/pubmed PY - 2019/6/25/medline SP - 4400 EP - 4400 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med. Sci. Monit. VL - 25 N2 - This article is retracted due to authors' claims in regards to errors in data and statistical analyses. Authors' message: We greatly regret to inform you that we just discovered some fatal errors in the statistical analysis, in which we mistakenly used the cultured cells TCR sequencing data as the results of CD8+ LAG3+ and CD8 LAG3-T cells. Therefore, the current results and data have serious defects and do not accurately represent the sorted cells. On behalf of all the contributing authors of the manuscript, we have decided to immediately retract the manuscript titled "LAG-3 receptor identifies a higher tumor-reactive cell population in the peripheral blood of colorectal cancer patients" to avoid further problems. SN - 1643-3750 UR - https://www.unboundmedicine.com/medline/citation/31233010/Retracted:_Expression_of_Lymphocyte-Activation_Gene_3_(LAG-3)_Immune_Checkpoint_Receptor_Identifies_a_Tumor-Reactive_T_Cell_Population_in_the_Peripheral_Blood_of_Patients_with_Colorectal_Cancer L2 - https://www.medscimonit.com/download/index/idArt/917907 DB - PRIME DP - Unbound Medicine ER -