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The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases.
Int J Mol Sci. 2019 Jun 22; 20(12)IJ

Abstract

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), currently affect more than 6 million people in the United States. Unfortunately, there are no treatments that slow or prevent disease development and progression. Regardless of the underlying cause of the disorder, age is the strongest risk factor for developing these maladies, suggesting that changes that occur in the aging brain put it at increased risk for neurodegenerative disease development. Moreover, since there are a number of different changes that occur in the aging brain, it is unlikely that targeting a single change is going to be effective for disease treatment. Thus, compounds that have multiple biological activities that can impact the various age-associated changes in the brain that contribute to neurodegenerative disease development and progression are needed. The plant-derived flavonoids have a wide range of activities that could make them particularly effective for blocking the age-associated toxicity pathways associated with neurodegenerative diseases. In this review, the evidence for beneficial effects of multiple flavonoids in models of AD, PD, HD, and ALS is presented and common mechanisms of action are identified. Overall, the preclinical data strongly support further investigation of specific flavonoids for the treatment of neurodegenerative diseases.

Authors+Show Affiliations

Salk Institute for Biological Studies, La Jolla, CA 92037, USA. pmaher@salk.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31234550

Citation

Maher, Pamela. "The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases." International Journal of Molecular Sciences, vol. 20, no. 12, 2019.
Maher P. The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases. Int J Mol Sci. 2019;20(12).
Maher, P. (2019). The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases. International Journal of Molecular Sciences, 20(12). https://doi.org/10.3390/ijms20123056
Maher P. The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases. Int J Mol Sci. 2019 Jun 22;20(12) PubMed PMID: 31234550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases. A1 - Maher,Pamela, Y1 - 2019/06/22/ PY - 2019/05/24/received PY - 2019/06/07/revised PY - 2019/06/18/accepted PY - 2019/6/26/entrez PY - 2019/6/27/pubmed PY - 2020/1/21/medline KW - cell death KW - cognitive dysfunction KW - inflammation KW - neurodegenerative disease KW - oxidative stress KW - protein aggregation KW - synapse loss JF - International journal of molecular sciences JO - Int J Mol Sci VL - 20 IS - 12 N2 - Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), currently affect more than 6 million people in the United States. Unfortunately, there are no treatments that slow or prevent disease development and progression. Regardless of the underlying cause of the disorder, age is the strongest risk factor for developing these maladies, suggesting that changes that occur in the aging brain put it at increased risk for neurodegenerative disease development. Moreover, since there are a number of different changes that occur in the aging brain, it is unlikely that targeting a single change is going to be effective for disease treatment. Thus, compounds that have multiple biological activities that can impact the various age-associated changes in the brain that contribute to neurodegenerative disease development and progression are needed. The plant-derived flavonoids have a wide range of activities that could make them particularly effective for blocking the age-associated toxicity pathways associated with neurodegenerative diseases. In this review, the evidence for beneficial effects of multiple flavonoids in models of AD, PD, HD, and ALS is presented and common mechanisms of action are identified. Overall, the preclinical data strongly support further investigation of specific flavonoids for the treatment of neurodegenerative diseases. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/31234550/The_Potential_of_Flavonoids_for_the_Treatment_of_Neurodegenerative_Diseases_ L2 - https://www.mdpi.com/resolver?pii=ijms20123056 DB - PRIME DP - Unbound Medicine ER -