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Maternal pre-pregnancy obesity and timing of puberty in sons and daughters: a population-based cohort study.
Int J Epidemiol. 2019 10 01; 48(5):1684-1694.IJ

Abstract

BACKGROUND

In many countries, an increased prevalence of obesity in pregnancy has coincided with a declining pubertal age. We aimed to explore the potential effect of maternal pre-pregnancy overweight and obesity on timing of puberty in sons and daughters.

METHODS

Between 2012 and 2018, 15 819 of 22 439 invited children from the Danish National Birth Cohort, born 2000-03, provided half-yearly information from the age of 11 years on the pubertal milestones: Tanner stages, voice break, first ejaculation, menarche, acne and axillary hair. We estimated adjusted mean monthly differences (with 95% confidence intervals) in age at attaining the pubertal milestones for children exposed to maternal pre-pregnancy obesity [body mass index (BMI) ≥30.0 kg/m2] or overweight (BMI 25.0 to 29.9 kg/m2) with normal weight (BMI 18.5 to 24.9 kg/m2) as reference. In mediation analysis, we explored whether childhood BMI at age 7 years mediated the associations.

RESULTS

Maternal pre-pregnancy obesity was associated with earlier age at attaining most pubertal milestones in sons, and pre-pregnancy overweight and obesity were associated with earlier age at attaining all pubertal milestones in daughters. When combining all pubertal milestones, pre-pregnancy obesity [sons: -1.5 (-2.5, -0.4) months; daughters: -3.2 (-4.2, -2.1) months] and overweight [daughters only: -2.6 (-3.3, -1.8) months] were associated with earlier timing of puberty. The associations in sons were completely mediated by higher childhood BMI and partly so in daughters.

CONCLUSIONS

Maternal pre-pregnancy obesity appears to lower timing of puberty through childhood obesity in sons and mainly through other mechanisms in daughters.

Authors+Show Affiliations

Department of Public Health, Aarhus University, Aarhus, Denmark. Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, CA, USA.Department of Public Health, Aarhus University, Aarhus, Denmark. Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, CA, USA.Department of Public Health, Aarhus University, Aarhus, Denmark.Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, CA, USA. Department of Statistics, UCLA College of Letters and Science, Los Angeles, CA, USA.Department of Clinical Research, Research Unit for Gynaecology and Obstetrics, University of Southern Denmark, Odense, Denmark.Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, CA, USA. Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.Perinatal Epidemiology Research Unit, Department of Paediatrics, Aarhus University Hospital, Aarhus, Denmark.Department of Public Health, Aarhus University, Aarhus, Denmark.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31237934

Citation

Brix, Nis, et al. "Maternal Pre-pregnancy Obesity and Timing of Puberty in Sons and Daughters: a Population-based Cohort Study." International Journal of Epidemiology, vol. 48, no. 5, 2019, pp. 1684-1694.
Brix N, Ernst A, Lauridsen LLB, et al. Maternal pre-pregnancy obesity and timing of puberty in sons and daughters: a population-based cohort study. Int J Epidemiol. 2019;48(5):1684-1694.
Brix, N., Ernst, A., Lauridsen, L. L. B., Arah, O. A., Nohr, E. A., Olsen, J., Henriksen, T. B., & Ramlau-Hansen, C. H. (2019). Maternal pre-pregnancy obesity and timing of puberty in sons and daughters: a population-based cohort study. International Journal of Epidemiology, 48(5), 1684-1694. https://doi.org/10.1093/ije/dyz125
Brix N, et al. Maternal Pre-pregnancy Obesity and Timing of Puberty in Sons and Daughters: a Population-based Cohort Study. Int J Epidemiol. 2019 10 1;48(5):1684-1694. PubMed PMID: 31237934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal pre-pregnancy obesity and timing of puberty in sons and daughters: a population-based cohort study. AU - Brix,Nis, AU - Ernst,Andreas, AU - Lauridsen,Lea L B, AU - Arah,Onyebuchi A, AU - Nohr,Ellen A, AU - Olsen,Jørn, AU - Henriksen,Tine Brink, AU - Ramlau-Hansen,Cecilia Høst, PY - 2019/06/20/accepted PY - 2019/6/27/pubmed PY - 2020/5/13/medline PY - 2019/6/26/entrez KW - Obesity KW - adiposity KW - maternal exposure KW - menarche KW - prenatal exposure delayed effects KW - puberty SP - 1684 EP - 1694 JF - International journal of epidemiology JO - Int J Epidemiol VL - 48 IS - 5 N2 - BACKGROUND: In many countries, an increased prevalence of obesity in pregnancy has coincided with a declining pubertal age. We aimed to explore the potential effect of maternal pre-pregnancy overweight and obesity on timing of puberty in sons and daughters. METHODS: Between 2012 and 2018, 15 819 of 22 439 invited children from the Danish National Birth Cohort, born 2000-03, provided half-yearly information from the age of 11 years on the pubertal milestones: Tanner stages, voice break, first ejaculation, menarche, acne and axillary hair. We estimated adjusted mean monthly differences (with 95% confidence intervals) in age at attaining the pubertal milestones for children exposed to maternal pre-pregnancy obesity [body mass index (BMI) ≥30.0 kg/m2] or overweight (BMI 25.0 to 29.9 kg/m2) with normal weight (BMI 18.5 to 24.9 kg/m2) as reference. In mediation analysis, we explored whether childhood BMI at age 7 years mediated the associations. RESULTS: Maternal pre-pregnancy obesity was associated with earlier age at attaining most pubertal milestones in sons, and pre-pregnancy overweight and obesity were associated with earlier age at attaining all pubertal milestones in daughters. When combining all pubertal milestones, pre-pregnancy obesity [sons: -1.5 (-2.5, -0.4) months; daughters: -3.2 (-4.2, -2.1) months] and overweight [daughters only: -2.6 (-3.3, -1.8) months] were associated with earlier timing of puberty. The associations in sons were completely mediated by higher childhood BMI and partly so in daughters. CONCLUSIONS: Maternal pre-pregnancy obesity appears to lower timing of puberty through childhood obesity in sons and mainly through other mechanisms in daughters. SN - 1464-3685 UR - https://www.unboundmedicine.com/medline/citation/31237934/Maternal_pre_pregnancy_obesity_and_timing_of_puberty_in_sons_and_daughters:_a_population_based_cohort_study_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyz125 DB - PRIME DP - Unbound Medicine ER -