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Bisphenol A and cognitive function in school-age boys: Is BPA predominantly related to behavior?
Neurotoxicology. 2019 09; 74:162-171.N

Abstract

BACKGROUND

Bisphenol A (BPA) has been associated with impairments in children's behavior, but few studies have investigated its relationship with cognitive function.

OBJECTIVE

To investigate the association of urinary BPA concentrations with cognitive domains and intelligence quotient (IQ) in Spanish boys.

METHODS

BPA levels were quantified by liquid chromatography-tandem mass spectrometry (LC-MS-MS) in one spot urine sample from 269 boys of the INMA-Granada cohort, in their follow-up at 9-11 years of age. Cognitive function was evaluated by a trained psychologist using a comprehensive neuropsychological test battery (including general intelligence, language skills, working memory, attention, impulsivity, visual-motor coordination, processing speed and executive function, among others). Cross-sectional associations between BPA levels and neuropsychological standardized scores were analyzed by adjusted linear and logistic regression models.

RESULTS

Median (P25, P75) BPA concentrations were 4.76 (2.77, 9.03) μg/L and 4.75 (2.75, 10.2) μg/g of creatinine (Cr). Boys in the third and fourth quartile of volume-based BPA concentrations showed better processing speed scores than boys in the first quartile (β = 5.47; 95%CI: 1.4, 9.4 and β = 3.57; 95%CI: -0.4, 7.5, respectively); and boys in the third quartile showed better inhibitory control (β = 1.6; 95%CI: -0.3, 3.5) and impulsivity (β= -4.2; 95%CI: -9.0, 0.0). In contrast, boys in the fourth quartile showed poorer working memory scores than those in the first quartile (β= -1.0; 95%CI: -2.1, -0.1). All these associations were attenuated when Cr-standardized BPA concentrations were considered. Cr-based BPA concentrations were also associated with a higher risk of being below the 20th percentile of working memory scores [ORa = 1.51; 95%CI: 1.01, 2.25].

DISCUSSION

Our findings do not support an association between urinary BPA concentrations and cognitive function or IQ among boys, except for working memory. BPA was previously found to be associated with behavior problems in the same study population, suggesting that BPA may predominantly affect the behavior of children rather than their cognitive function, in line with previous epidemiologic studies.

Authors+Show Affiliations

University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto de Investigación Biosanitaria Ibs GRANADA, Spain.University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto de Investigación Biosanitaria Ibs GRANADA, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 18100, Spain. Electronic address: vmustieles@ugr.es.University of Granada, Center for Biomedical Research (CIBM), Spain.University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto de Investigación Biosanitaria Ibs GRANADA, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 18100, Spain.University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto de Investigación Biosanitaria Ibs GRANADA, Spain.University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto de Investigación Biosanitaria Ibs GRANADA, Spain.University of Córdoba, Institute of Fine Chemistry and Nanochemistry, 14017 Córdoba, Spain.University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto de Investigación Biosanitaria Ibs GRANADA, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 18100, Spain.University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto de Investigación Biosanitaria Ibs GRANADA, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 18100, Spain. Electronic address: marieta@ugr.es.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31238050

Citation

Rodríguez-Carrillo, Andrea, et al. "Bisphenol a and Cognitive Function in School-age Boys: Is BPA Predominantly Related to Behavior?" Neurotoxicology, vol. 74, 2019, pp. 162-171.
Rodríguez-Carrillo A, Mustieles V, Pérez-Lobato R, et al. Bisphenol A and cognitive function in school-age boys: Is BPA predominantly related to behavior? Neurotoxicology. 2019;74:162-171.
Rodríguez-Carrillo, A., Mustieles, V., Pérez-Lobato, R., Molina-Molina, J. M., Reina-Pérez, I., Vela-Soria, F., Rubio, S., Olea, N., & Fernández, M. F. (2019). Bisphenol A and cognitive function in school-age boys: Is BPA predominantly related to behavior? Neurotoxicology, 74, 162-171. https://doi.org/10.1016/j.neuro.2019.06.006
Rodríguez-Carrillo A, et al. Bisphenol a and Cognitive Function in School-age Boys: Is BPA Predominantly Related to Behavior. Neurotoxicology. 2019;74:162-171. PubMed PMID: 31238050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bisphenol A and cognitive function in school-age boys: Is BPA predominantly related to behavior? AU - Rodríguez-Carrillo,Andrea, AU - Mustieles,Vicente, AU - Pérez-Lobato,Rocío, AU - Molina-Molina,José M, AU - Reina-Pérez,Iris, AU - Vela-Soria,Fernando, AU - Rubio,Soledad, AU - Olea,Nicolás, AU - Fernández,Mariana F, Y1 - 2019/06/22/ PY - 2019/03/14/received PY - 2019/06/10/revised PY - 2019/06/21/accepted PY - 2019/6/27/pubmed PY - 2020/5/13/medline PY - 2019/6/26/entrez KW - BPA KW - Behavior KW - Bisphenol A KW - Cognitive function KW - EDCs KW - Endocrine disrupting chemicals KW - IQ SP - 162 EP - 171 JF - Neurotoxicology JO - Neurotoxicology VL - 74 N2 - BACKGROUND: Bisphenol A (BPA) has been associated with impairments in children's behavior, but few studies have investigated its relationship with cognitive function. OBJECTIVE: To investigate the association of urinary BPA concentrations with cognitive domains and intelligence quotient (IQ) in Spanish boys. METHODS: BPA levels were quantified by liquid chromatography-tandem mass spectrometry (LC-MS-MS) in one spot urine sample from 269 boys of the INMA-Granada cohort, in their follow-up at 9-11 years of age. Cognitive function was evaluated by a trained psychologist using a comprehensive neuropsychological test battery (including general intelligence, language skills, working memory, attention, impulsivity, visual-motor coordination, processing speed and executive function, among others). Cross-sectional associations between BPA levels and neuropsychological standardized scores were analyzed by adjusted linear and logistic regression models. RESULTS: Median (P25, P75) BPA concentrations were 4.76 (2.77, 9.03) μg/L and 4.75 (2.75, 10.2) μg/g of creatinine (Cr). Boys in the third and fourth quartile of volume-based BPA concentrations showed better processing speed scores than boys in the first quartile (β = 5.47; 95%CI: 1.4, 9.4 and β = 3.57; 95%CI: -0.4, 7.5, respectively); and boys in the third quartile showed better inhibitory control (β = 1.6; 95%CI: -0.3, 3.5) and impulsivity (β= -4.2; 95%CI: -9.0, 0.0). In contrast, boys in the fourth quartile showed poorer working memory scores than those in the first quartile (β= -1.0; 95%CI: -2.1, -0.1). All these associations were attenuated when Cr-standardized BPA concentrations were considered. Cr-based BPA concentrations were also associated with a higher risk of being below the 20th percentile of working memory scores [ORa = 1.51; 95%CI: 1.01, 2.25]. DISCUSSION: Our findings do not support an association between urinary BPA concentrations and cognitive function or IQ among boys, except for working memory. BPA was previously found to be associated with behavior problems in the same study population, suggesting that BPA may predominantly affect the behavior of children rather than their cognitive function, in line with previous epidemiologic studies. SN - 1872-9711 UR - https://www.unboundmedicine.com/medline/citation/31238050/Bisphenol_A_and_cognitive_function_in_school_age_boys:_Is_BPA_predominantly_related_to_behavior L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(19)30054-3 DB - PRIME DP - Unbound Medicine ER -