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Ophthalmic Manifestations of Mycoplasma-Induced Rash and Mucositis.
Cornea. 2019 Oct; 38(10):1305-1308.C

Abstract

PURPOSE

Mycoplasma pneumoniae is a common cause of pediatric respiratory infections, with a quarter having extrapulmonary complications, most commonly a mucocutaneous eruption involving the ocular surface. A detailed description of the ophthalmic manifestations in Mycoplasma-induced rash and mucositis (MIRM) is currently lacking in the scientific literature.

METHODS

This is a retrospective chart review of consecutive cases of MIRM at a tertiary referral children's hospital between October 1 and December 1, 2018, with up to 2 months of follow-up. Main outcomes and measures were demographic information, clinical examination findings including visual acuity, detailed anterior segment findings, and course of both ophthalmic and systemic disease.

RESULTS

Five patients were included. Age range was 8 to 17 years (mean age 11.9 years, median 11 years), with a strong male preponderance (4:1). All patients had inflammatory conjunctivitis. One patient had recurrent conjunctival pseudomembrane formation, whereas 2 patients had lid margin and conjunctival ulceration. No cases had corneal involvement and visual outcomes were excellent.

CONCLUSIONS

MIRM is associated with ocular involvement in almost all cases. Although this is generally mild, conjunctival epithelial defects and pseudomembrane formation can occur. We recommend that pediatric ophthalmologists follow children who are hospitalized with MIRM as closely as they would those diagnosed with other mucocutaneous syndromes, such as Stevens-Johnson syndrome or toxic epidermal necrolysis.

Authors+Show Affiliations

UPMC Eye Center, Pittsburgh, PA. UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.UPMC Eye Center, Pittsburgh, PA. UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.UPMC Eye Center, Pittsburgh, PA. UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA. School of Medicine, University of Pittsburgh, Pittsburgh, PA.UPMC Eye Center, Pittsburgh, PA. UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA. School of Medicine, University of Pittsburgh, Pittsburgh, PA.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

31246679

Citation

Shah, Parth R., et al. "Ophthalmic Manifestations of Mycoplasma-Induced Rash and Mucositis." Cornea, vol. 38, no. 10, 2019, pp. 1305-1308.
Shah PR, Williams AM, Pihlblad MS, et al. Ophthalmic Manifestations of Mycoplasma-Induced Rash and Mucositis. Cornea. 2019;38(10):1305-1308.
Shah, P. R., Williams, A. M., Pihlblad, M. S., & Nischal, K. K. (2019). Ophthalmic Manifestations of Mycoplasma-Induced Rash and Mucositis. Cornea, 38(10), 1305-1308. https://doi.org/10.1097/ICO.0000000000001985
Shah PR, et al. Ophthalmic Manifestations of Mycoplasma-Induced Rash and Mucositis. Cornea. 2019;38(10):1305-1308. PubMed PMID: 31246679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ophthalmic Manifestations of Mycoplasma-Induced Rash and Mucositis. AU - Shah,Parth R, AU - Williams,Andrew M, AU - Pihlblad,Matthew S, AU - Nischal,Ken K, PY - 2019/6/28/pubmed PY - 2019/12/24/medline PY - 2019/6/28/entrez SP - 1305 EP - 1308 JF - Cornea JO - Cornea VL - 38 IS - 10 N2 - PURPOSE: Mycoplasma pneumoniae is a common cause of pediatric respiratory infections, with a quarter having extrapulmonary complications, most commonly a mucocutaneous eruption involving the ocular surface. A detailed description of the ophthalmic manifestations in Mycoplasma-induced rash and mucositis (MIRM) is currently lacking in the scientific literature. METHODS: This is a retrospective chart review of consecutive cases of MIRM at a tertiary referral children's hospital between October 1 and December 1, 2018, with up to 2 months of follow-up. Main outcomes and measures were demographic information, clinical examination findings including visual acuity, detailed anterior segment findings, and course of both ophthalmic and systemic disease. RESULTS: Five patients were included. Age range was 8 to 17 years (mean age 11.9 years, median 11 years), with a strong male preponderance (4:1). All patients had inflammatory conjunctivitis. One patient had recurrent conjunctival pseudomembrane formation, whereas 2 patients had lid margin and conjunctival ulceration. No cases had corneal involvement and visual outcomes were excellent. CONCLUSIONS: MIRM is associated with ocular involvement in almost all cases. Although this is generally mild, conjunctival epithelial defects and pseudomembrane formation can occur. We recommend that pediatric ophthalmologists follow children who are hospitalized with MIRM as closely as they would those diagnosed with other mucocutaneous syndromes, such as Stevens-Johnson syndrome or toxic epidermal necrolysis. SN - 1536-4798 UR - https://www.unboundmedicine.com/medline/citation/31246679/Ophthalmic_Manifestations_of_Mycoplasma_Induced_Rash_and_Mucositis_ L2 - http://dx.doi.org/10.1097/ICO.0000000000001985 DB - PRIME DP - Unbound Medicine ER -