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A lateral inhibition mechanism explains the dissociation between mismatch negativity and behavioral pitch discrimination.
Brain Res. 2019 10 01; 1720:146308.BR

Abstract

Although mismatch negativity (MMN), a change-specific component of auditory event-related potential, is considered to be an index of sound discrimination accuracy, the amplitude of the MMN responses elicited by pitch height deviations in musicians and tone language speakers with superior pitch discrimination is usually not enhanced compared to that elicited in individuals with inferior pitch discrimination. We hypothesized that superior pitch discrimination is accompanied by enhanced lateral inhibition, a critical neural mechanism that sharpens the tuning curves of the auditory neurons in the tonotopy. Forty Mandarin-speaking healthy adults completed an auditory EEG experiment in which MMN was elicited by pitch height deviations in both pure and harmonic tones. Their behavioral pitch discrimination was indexed by the difference limens measured using pure and harmonic tones. Behavioral pitch discrimination correlated significantly with the MMN elicited by pure tones, but not by harmonic tones; this could be due to lateral inhibition strongly influencing the MMN elicited by harmonic tones but having less effect on the MMN elicited by pure tones. As lateral inhibition is a neural mechanism for attenuating the amplitude of MMN, our results support the notion that an enhanced lateral inhibition mechanism underlies superior pitch discrimination.

Authors+Show Affiliations

Division of Speech and Hearing Sciences, The University of Hong Kong, Hong Kong.Division of Speech and Hearing Sciences, The University of Hong Kong, Hong Kong.Key Lab of China's National Linguistic Information Technology, Northwest Minzu University, Lanzhou, China.CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei, China.Division of Speech and Hearing Sciences, The University of Hong Kong, Hong Kong. Electronic address: xltong@hku.hk.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31247205

Citation

Gu, Feng, et al. "A Lateral Inhibition Mechanism Explains the Dissociation Between Mismatch Negativity and Behavioral Pitch Discrimination." Brain Research, vol. 1720, 2019, p. 146308.
Gu F, Wong L, Hu A, et al. A lateral inhibition mechanism explains the dissociation between mismatch negativity and behavioral pitch discrimination. Brain Res. 2019;1720:146308.
Gu, F., Wong, L., Hu, A., Zhang, X., & Tong, X. (2019). A lateral inhibition mechanism explains the dissociation between mismatch negativity and behavioral pitch discrimination. Brain Research, 1720, 146308. https://doi.org/10.1016/j.brainres.2019.146308
Gu F, et al. A Lateral Inhibition Mechanism Explains the Dissociation Between Mismatch Negativity and Behavioral Pitch Discrimination. Brain Res. 2019 10 1;1720:146308. PubMed PMID: 31247205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A lateral inhibition mechanism explains the dissociation between mismatch negativity and behavioral pitch discrimination. AU - Gu,Feng, AU - Wong,Lena, AU - Hu,Axu, AU - Zhang,Xiaochu, AU - Tong,Xiuli, Y1 - 2019/06/24/ PY - 2018/12/07/received PY - 2019/04/20/revised PY - 2019/06/23/accepted PY - 2019/6/28/pubmed PY - 2020/9/25/medline PY - 2019/6/28/entrez KW - Auditory discrimination KW - Lateral inhibition KW - Mismatch negativity KW - Oddball paradigm KW - Pitch perception KW - Tonotopy SP - 146308 EP - 146308 JF - Brain research JO - Brain Res VL - 1720 N2 - Although mismatch negativity (MMN), a change-specific component of auditory event-related potential, is considered to be an index of sound discrimination accuracy, the amplitude of the MMN responses elicited by pitch height deviations in musicians and tone language speakers with superior pitch discrimination is usually not enhanced compared to that elicited in individuals with inferior pitch discrimination. We hypothesized that superior pitch discrimination is accompanied by enhanced lateral inhibition, a critical neural mechanism that sharpens the tuning curves of the auditory neurons in the tonotopy. Forty Mandarin-speaking healthy adults completed an auditory EEG experiment in which MMN was elicited by pitch height deviations in both pure and harmonic tones. Their behavioral pitch discrimination was indexed by the difference limens measured using pure and harmonic tones. Behavioral pitch discrimination correlated significantly with the MMN elicited by pure tones, but not by harmonic tones; this could be due to lateral inhibition strongly influencing the MMN elicited by harmonic tones but having less effect on the MMN elicited by pure tones. As lateral inhibition is a neural mechanism for attenuating the amplitude of MMN, our results support the notion that an enhanced lateral inhibition mechanism underlies superior pitch discrimination. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/31247205/A_lateral_inhibition_mechanism_explains_the_dissociation_between_mismatch_negativity_and_behavioral_pitch_discrimination_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(19)30354-3 DB - PRIME DP - Unbound Medicine ER -