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The sex-specific association between maternal paraben exposure and size at birth.
Int J Hyg Environ Health. 2019 07; 222(6):955-964.IJ

Abstract

Parabens are a group of esters of parahydroxybenzoic acid and are utilized as antimicrobial preservatives in the majority of personal care products (PCPs). Epidemiological studies regarding the adverse effects of parabens on fetuses are still limited. The aim of this study was to determine the association between maternal paraben exposure and birth outcomes. One hundred and ninety-nine pregnant women were enrolled, and maternal urine was collected in the third trimester. The urine concentrations of four parabens (methyl (MP), ethyl (EP), propyl (PP), and butyl (BP)) were determined by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Generalized additive model-penalized regression splines and a multivariable regression model were employed to determine the association between paraben exposure levels and birth outcomes. A causal mediation analysis was conducted to determine the mediation effect of oxidative stress on birth outcomes. The geometric means of urinary MP, EP, PP, and BP were 51.79, 1.26, 4.21, and 1.25 μg/g cre., respectively. In the penalized regression splines, sex-specific associations between maternal MP levels and birth outcomes were observed; a downward curvature was observed between the MP level and birth weight, length, head circumference, and thoracic circumference among female newborns. Pregnant women in the group with MP levels above the third quartile had neonates with significantly lower body weight (β = -215.98 g, p value = 0.02) compared to those in the group with MP levels lower than the third quartile. No significant mediation of oxidative stress was observed between maternal MP exposure and female birth weight. The estimated proportion mediated ranged from -6% to 15%. The negative association between maternal paraben exposure and female birth outcomes in relation to child development should be carefully considered.

Authors+Show Affiliations

Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming University, Taipei, Taiwan.Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming University, Taipei, Taiwan; Department of Pediatrics, Taipei City Hospital, Heping Fuyou Branch, Taipei, Taiwan.Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming University, Taipei, Taiwan.Department of Safety, Health and Environmental Engineering, National United University, Miaoli, Taiwan.Department of Obstetrics & Gynecology, Taipei City Hospital, Heping Fuyou Branch, Taipei, Taiwan.Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, Taiwan.Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming University, Taipei, Taiwan.Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming University, Taipei, Taiwan.Division of Pediatrics, Taipei City Hospital, Yangming Branch, Taipei, Taiwan.Department of Occupational Safety and Health, Chung Shan Medical University, Taichung, Taiwan.Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming University, Taipei, Taiwan. Electronic address: mlchen@ym.edu.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31248753

Citation

Chang, Chia-Huang, et al. "The Sex-specific Association Between Maternal Paraben Exposure and Size at Birth." International Journal of Hygiene and Environmental Health, vol. 222, no. 6, 2019, pp. 955-964.
Chang CH, Wang PW, Liang HW, et al. The sex-specific association between maternal paraben exposure and size at birth. Int J Hyg Environ Health. 2019;222(6):955-964.
Chang, C. H., Wang, P. W., Liang, H. W., Huang, Y. F., Huang, L. W., Chen, H. C., Pan, W. C., Lin, M. H., Yang, W., Mao, I. F., & Chen, M. L. (2019). The sex-specific association between maternal paraben exposure and size at birth. International Journal of Hygiene and Environmental Health, 222(6), 955-964. https://doi.org/10.1016/j.ijheh.2019.06.004
Chang CH, et al. The Sex-specific Association Between Maternal Paraben Exposure and Size at Birth. Int J Hyg Environ Health. 2019;222(6):955-964. PubMed PMID: 31248753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The sex-specific association between maternal paraben exposure and size at birth. AU - Chang,Chia-Huang, AU - Wang,Pei-Wei, AU - Liang,Hai-Wei, AU - Huang,Yu-Fang, AU - Huang,Li-Wei, AU - Chen,Hsin-Chang, AU - Pan,Wen-Chi, AU - Lin,Meng-Han, AU - Yang,Winnie, AU - Mao,I-Fang, AU - Chen,Mei-Lien, Y1 - 2019/06/25/ PY - 2019/02/23/received PY - 2019/06/11/revised PY - 2019/06/17/accepted PY - 2019/6/30/pubmed PY - 2020/3/20/medline PY - 2019/6/29/entrez KW - Birth outcomes KW - Oxidative stress KW - Paraben KW - Pregnant women SP - 955 EP - 964 JF - International journal of hygiene and environmental health JO - Int J Hyg Environ Health VL - 222 IS - 6 N2 - Parabens are a group of esters of parahydroxybenzoic acid and are utilized as antimicrobial preservatives in the majority of personal care products (PCPs). Epidemiological studies regarding the adverse effects of parabens on fetuses are still limited. The aim of this study was to determine the association between maternal paraben exposure and birth outcomes. One hundred and ninety-nine pregnant women were enrolled, and maternal urine was collected in the third trimester. The urine concentrations of four parabens (methyl (MP), ethyl (EP), propyl (PP), and butyl (BP)) were determined by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Generalized additive model-penalized regression splines and a multivariable regression model were employed to determine the association between paraben exposure levels and birth outcomes. A causal mediation analysis was conducted to determine the mediation effect of oxidative stress on birth outcomes. The geometric means of urinary MP, EP, PP, and BP were 51.79, 1.26, 4.21, and 1.25 μg/g cre., respectively. In the penalized regression splines, sex-specific associations between maternal MP levels and birth outcomes were observed; a downward curvature was observed between the MP level and birth weight, length, head circumference, and thoracic circumference among female newborns. Pregnant women in the group with MP levels above the third quartile had neonates with significantly lower body weight (β = -215.98 g, p value = 0.02) compared to those in the group with MP levels lower than the third quartile. No significant mediation of oxidative stress was observed between maternal MP exposure and female birth weight. The estimated proportion mediated ranged from -6% to 15%. The negative association between maternal paraben exposure and female birth outcomes in relation to child development should be carefully considered. SN - 1618-131X UR - https://www.unboundmedicine.com/medline/citation/31248753/The_sex_specific_association_between_maternal_paraben_exposure_and_size_at_birth_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1438-4639(19)30173-7 DB - PRIME DP - Unbound Medicine ER -