Tags

Type your tag names separated by a space and hit enter

Second to fourth digit ratio in female patients with acne vulgaris: Could it be a predictor of androgen receptor status?

Abstract

Background

Second to fourth digit (2D:4D) ratio is the ratio of index to ring fingers length. It reflects prenatal androgen exposure and sensitivity. Androgens are important in the pathogenesis of acne vulgaris, This ratio may therefore be of significance in determining the expression of androgen receptors.

Aim

To investigate the relationship between second to fourth digit ratio and androgen receptor expression in female patients with acne vulgaris and to assess its association with clinical aspects of acne vulgaris.

Methods

Females patients (n = 352) with different degrees of acne vulgaris severity and 168 age-matched females were enrolled. Right, left and total second to fourth digit ratios were calculated. Biopsies from all participants were processed for androgen receptor expression by immunohistochemical method.

Results

Right, left and total second to fourth digit ratios were significantly lower in acne vulgaris patients than controls (P < 0.001 for all), and each of them had a significant negative correlation with duration of acne vulgaris (P < 0.001; P = 0.013; P < 0.001, respectively). Androgen receptors were detected in epidermal keratinocytes, hair follicles, sebaceous glands and fibroblasts. Right second to fourth digit ratio showed a negative correlation with androgen receptor H score of keratinocytes (r = -0.28;P = 0.02), hair follicles (r = -0.22;P = 0.05) and fibroblasts (r = -0.37;P = 0.001), while left second to fourth digit ratio demonstrated negative correlation with androgen receptor H score of sebocytes (r = -0.397;P < 0.000) only.

Limitations

Lack of follow-up and absence of male participants were the main limitations of this study.

Conclusion

A masculine second to fourth digit ratio in female patients could anticipate acne vulgaris development, its duration and severity. Moreover, this ratio is associated with an upregulation of cutaneous androgen receptors. Taken together, second to fourth digit ratio could help in designing plans for treatment of acne vulgaris.

Authors+Show Affiliations

Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Al Minufya, Egypt.Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Al Minufya, Egypt.Department of Pathology, Faculty of Medicine, Menoufia University, Al Minufya, Egypt.Department of Pathology, Faculty of Medicine, Menoufia University, Al Minufya, Egypt.Department of Clinical Pharmacy, Faculty of Pharmacy, MSA University, October City, Egypt.Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Al Minufya, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31249215

Citation

Farag, Azza Gaber Antar, et al. "Second to Fourth Digit Ratio in Female Patients With Acne Vulgaris: Could It Be a Predictor of Androgen Receptor Status?" Indian Journal of Dermatology, Venereology and Leprology, 2019.
Farag AGA, Shoiab MA, Samaka R, et al. Second to fourth digit ratio in female patients with acne vulgaris: Could it be a predictor of androgen receptor status? Indian J Dermatol Venereol Leprol. 2019.
Farag, A. G. A., Shoiab, M. A., Samaka, R., Abdou, A. G., Elnaidany, N. F., & Mansour, A. O. M. (2019). Second to fourth digit ratio in female patients with acne vulgaris: Could it be a predictor of androgen receptor status? Indian Journal of Dermatology, Venereology and Leprology, doi:10.4103/ijdvl.IJDVL_35_18.
Farag AGA, et al. Second to Fourth Digit Ratio in Female Patients With Acne Vulgaris: Could It Be a Predictor of Androgen Receptor Status. Indian J Dermatol Venereol Leprol. 2019 Jun 24; PubMed PMID: 31249215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Second to fourth digit ratio in female patients with acne vulgaris: Could it be a predictor of androgen receptor status? AU - Farag,Azza Gaber Antar, AU - Shoiab,Mohamed Ahmed, AU - Samaka,Rehab, AU - Abdou,Asmaa Gaber, AU - Elnaidany,Nada Farag, AU - Mansour,Asmhan Omar M, Y1 - 2019/06/24/ PY - 2019/6/29/entrez PY - 2019/6/30/pubmed PY - 2019/6/30/medline KW - Acne vulgaris KW - androgen receptor KW - digit ratio KW - immunohistochemistry JF - Indian journal of dermatology, venereology and leprology JO - Indian J Dermatol Venereol Leprol N2 - Background: Second to fourth digit (2D:4D) ratio is the ratio of index to ring fingers length. It reflects prenatal androgen exposure and sensitivity. Androgens are important in the pathogenesis of acne vulgaris, This ratio may therefore be of significance in determining the expression of androgen receptors. Aim: To investigate the relationship between second to fourth digit ratio and androgen receptor expression in female patients with acne vulgaris and to assess its association with clinical aspects of acne vulgaris. Methods: Females patients (n = 352) with different degrees of acne vulgaris severity and 168 age-matched females were enrolled. Right, left and total second to fourth digit ratios were calculated. Biopsies from all participants were processed for androgen receptor expression by immunohistochemical method. Results: Right, left and total second to fourth digit ratios were significantly lower in acne vulgaris patients than controls (P < 0.001 for all), and each of them had a significant negative correlation with duration of acne vulgaris (P < 0.001; P = 0.013; P < 0.001, respectively). Androgen receptors were detected in epidermal keratinocytes, hair follicles, sebaceous glands and fibroblasts. Right second to fourth digit ratio showed a negative correlation with androgen receptor H score of keratinocytes (r = -0.28;P = 0.02), hair follicles (r = -0.22;P = 0.05) and fibroblasts (r = -0.37;P = 0.001), while left second to fourth digit ratio demonstrated negative correlation with androgen receptor H score of sebocytes (r = -0.397;P < 0.000) only. Limitations: Lack of follow-up and absence of male participants were the main limitations of this study. Conclusion: A masculine second to fourth digit ratio in female patients could anticipate acne vulgaris development, its duration and severity. Moreover, this ratio is associated with an upregulation of cutaneous androgen receptors. Taken together, second to fourth digit ratio could help in designing plans for treatment of acne vulgaris. SN - 0973-3922 UR - https://www.unboundmedicine.com/medline/citation/31249215/Second_to_fourth_digit_ratio_in_female_patients_with_acne_vulgaris:_Could_it_be_a_predictor_of_androgen_receptor_status L2 - http://www.ijdvl.com/preprintarticle.asp?id=261209;type=0 DB - PRIME DP - Unbound Medicine ER -